Page 76 - 南京医科大学学报自然科学版

南京医科大学学报（自然科学版） 第41卷第2期
·226 · Journal of Nanjing Medical University（Natural Sciences） 2021年2月

·临床研究·

3~15岁儿童变应性鼻炎舌下免疫治疗的短期疗效

田慧琴，周骁俐，胡幼芳 *
南京医科大学第一附属医院儿童保健科，江苏 南京 210029

［摘 要］ 目的：探讨儿童变应性鼻炎进行舌下特异性免疫治疗的短期疗效。方法：采用自身前后对照，比较71例3~15岁粉
尘螨致敏的变应性鼻炎儿童在进行标准化的粉尘螨滴剂舌下特异性免疫治疗后3、6、9、12个月的疗效情况。疗效评估包括鼻
炎症状总评分、药物总评分和视觉模拟量表（visual analogue score，VAS）评分情况。结果：进行粉尘螨舌下特异性免疫治疗后
的 3、6、9、12 个月时患者的鼻炎症状总评分、药物总评分以及 VAS 评分与治疗前相比均有下降，差异有统计学意义（P <
0.05）。6个月与3个月相比，以及9个月与6个月相比，鼻炎症状总评分、药物总评分和VAS评分均有下降，差异有统计学意义
（P < 0.05），12个月与9个月相比药物总评分无统计学差异（P > 0.05），但鼻炎症状总评分和VAS评分仍均有下降，差异有统计
学意义（P < 0.05）。结论：粉尘螨舌下特异性免疫治疗对儿童变应性鼻炎的短期疗效良好，在3个月就能起效，并在6、9、12个
月时得到持续改进。
［关键词］ 变应性鼻炎；尘螨；免疫治疗
［中图分类号］ R765 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）02⁃226⁃04
doi：10.7655/NYDXBNS20210214

Short ⁃ term effect of sublingual immunotherapy in 3 ⁃ 15 years old children with allergic
rhinitis
*
TIAN Huiqin，ZHOU Xiaoli，HU Youfang
Department of Child Health Care，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China

［Abstract］ Objective：This study aims to explore the short⁃term effect of sublingual allergen⁃specific immunotherapy in children
with allergic rhinitis. Methods：There were 71 subjects of 3⁃15 years old with allergic rhinitis who were sensitized to dermatophagoides
farinae. They were treated with standardized sublingual dermatophagoides farinae immunotherapy drops. Then the short⁃term effects of
the treatment were evaluated by comparing the outcome scores including the total rhinitis symptom scores，total medication scores and
visual analogue scale（VAS）before and after the treatment for every three months until a year. Results：Total rhinitis symptom scores，
total medication scores and VAS were all declined in 3 months，6 months，9 months and 12 months after the treatment compared with
those before the treatment. Meanwhile，the three scores were all declined in 6 months and 9 months compared with those in 3 months
and 6 months，respectively. Total rhinitis symptom scores and VAS were both declined while no difference was shown in total
medication scores in 12 months compared with those in 9 months. Conclusion：In the short term，sublingual dermatophagoides farinae
immunotherapy is an effective way to treat 3⁃15 years old children with allergic rhinitis who are sensitized to dermatophagoides farina，
which can take effect in 3 months after the treatment，and becomes more and more effective in 6 month，9 months and 12 months.
［Key words］ allergic rhinitis；dermatophagoides farinae；immunotherapy
［J Nanjing Med Univ，2021，41（02）：226⁃229］

变应性鼻炎是机体接触变应原后主要由IgE介
［基金项目］ 国家自然科学基金（81300834）；江苏省青年医
导的鼻黏膜非感染性炎性疾病。变应性鼻炎患病
学重点人才（QNRC2016607）；江苏省妇幼健康科研项目面
［1］
上项目（F201804） 率高且有逐年上升趋势 ，已经成为一种全球性疾
∗ 病。2005 年我国 11 个中心城市成人变应性鼻炎自
通信作者（Corresponding author），E⁃mail：13182823903@126.
［2］
com 报患病率为 8.7％~24.1％，平均为 11.1% ，而到