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第41卷第5期 陆晨妍,龚颖芸,付真真,等. IVGTT过程中血糖及胰岛素急遽波动对血清PCSK9水平的影响[J].
2021年5月 南京医科大学学报(自然科学版),2021,41(05):677-683 ·683 ·
A M. et al. PCSK9 and inflammation:a review of experi⁃ 科学版),2019,33(2):259-261
mental and clinical evidence[J]. Eur Heart J Cardiovasc [15] 茅国芳,王坤林,符金香,等. 2 型糖尿病患者血清 PC⁃
Pharmacother,2019,5(4):237-245 SK9与动脉粥样硬化指标的相关性分析[J]. 南京医科
[4] SPOLITU S,OKAMOTO H,DAI W,ZADROGA J A. et 大学学报(自然科学版),2016,36(1):46-50
al. Hepatic glucagon signaling regulates PCSK9 and low⁃ [16] HAMAMURA H,ADACHI H,ENOMOTO M. et al. Se⁃
density lipoprotein cholesterol[J]. Circ Res,2019,124 rum proprotein convertase subtilisin/kexin type 9(PC⁃
(1):38-51 SK9)is independently associated with insulin resistance,
[5] THEOCHARIDOU E,PAPADEMETRIOU M,REKLOU triglycerides,lipoprotein(a)levels but not low⁃density li⁃
A. et al. The role of PCSK9 in the pathogenesis of non⁃al⁃ poprotein cholesterol levels in a general population[J]. J
coholic fatty liver disease and the effect of PCSK9 inhibi⁃
Atheroscler Thromb,2020,28(4):329-337
tors[J]. Curr Pharm Des,2018,24(31):3654⁃3657
[17] MIAO J,MANTHENA P V,HAAS M E. et al. Role of in⁃
[6] GALLEGO⁃COLON E,DAUM A,YOSEFY C. Statins and
sulin in the regulation of proprotein convertase subtilisin/
PCSK9 inhibitors:a new lipid⁃lowering therapy[J]. Eur J kexin type 9 arterioscler[J]. Thromb Vasc Biol,2015,35:
Pharmacol,2020,878:173114
1589-1596
[7] FURTADO RHM,GIUGLIANO R P. What lessons have
[18] COSTET P,CARIOU B,LAMBERT G. et al. Hepatic PC⁃
we learned and what remains to be clarified for PCSK9 in⁃
SK9 expression is regulated by nutritional status via insu⁃
hibitors? a review of FOURIER and ODYSSEY outcomes
lin and sterol regulatory element⁃binding protein 1c[J]. J
trials[J]. Cardiol Ther,2020,9(1):59-73
Biol Chem,2006,281:6211-6218
[8] TURGEON R D,TSUYUKI R T,GYENES G T. et al. Car⁃
[19] AWAN Z,DUBUC G,FARAJ M. et al. The effect of insu⁃
diovascular efficacy and safety of PCSK9 inhibitors:sys⁃
lin on circulating PCSK9 in postmenopausal obese women
tematic review and meta ⁃ analysis including the ODYS⁃
[J]. Clin Biochem,2014,47:1033-1039
SEY OUTCOMES trial[J]. Can J Cardiol,2018,34(12):
[20]KAPPELLE P J,LAMBERT G,DULLAART R P. Plasma
1600-1605
proprotein convertase subtilisin ⁃ kexin type 9 does not
[9] CHEN B,SHI X,CUI Y. et al. A review of PCSK9 inhibi⁃
change during 24 h insulin infusion in healthy subjects
tors and their effects on cardiovascular diseases[J]. Curr
and type 2 diabetic patients[J]. Atherosclerosis,2011,
Top Med Chem,2019,19(20):1790-1817
214:432-435
[10] GUO W,GONG Y,GU Y. et al. Circulating PCSK9 levels
[21] ZENTI M G,LUPO M G,DE MARTIN S. et al. Impact of
and 2⁃hPG are positively correlated in metabolic diseases
bariatric surgery⁃induced weight loss on circulating PCSK9
in a Chinese Han population[J]. Lipids Health Dis,
levels in obese patients[J]. Nutr Metab Cardiovasc Dis,
2018,17(15)
2020,30(12):2372-2378
[11] BAASS A,DUBUC G,TREMBLAY M. et al. Plasma PC⁃
[22] GREFHORST A,MCNUTT M C,LAGACE T A. et al.
SK9 is associated with age,sex,and multiple metabolic
Plasma PCSK9 preferentially reduces liver LDL receptors
markers in a population⁃based sample of children and ad⁃
in mice[J]. J Lipid Res,2008,49:1303-1311
olescents[J]. Clin Chem,2009,55:1637-1645
[23] GONG Y,MA Y,YE Z. et al. Thyroid stimulating hor⁃
[12] PETERSEN K S,BOWEN K J,TINDALL A M. et al. The
mone exhibits the impact on LDLR/LDL⁃c via up⁃regulat⁃
effect of inflammation and insulin resistance on lipid and
ing hepatic PCSK9 expression[J]. Metab Clin Exp,2017,
lipoprotein responsiveness to dietary intervention[J].
76:32-41
Curr Dev Nutr,2020,15,4(11):nzaa160
[24]LU J,LAM SM,WAN Q. et al. High⁃coverage targeted lip⁃
[13] MURAKI I. Role of proprotein convertase subtilisin/Kex⁃
idomics reveals novel serum lipid predictors and lipid
in Type 9(PCSK9)on lipid metabolism and insulin resis⁃
tance in Human[J]. J Atheroscler Thromb,2020,28(4): pathway dysregulation antecedent to type 2 diabetes onset
in normoglycemic chinese adults[J]. Diabetes Care,
317-318
[14] 崔 琴,支晓明,郭 雯,等. 体检人群血清PCSK9与代 2019,42:2117-2126
谢综合征的相关性分析[J]. 南京医科大学学报(自然 [收稿日期] 2021-02-13