Page 35 - 南京医科大学学报自然科学版
P. 35
第42卷第5期 郁 蓉,彭云鹏,朱小乐,等. 游离脂肪酸通过IRE1/XBP1通路调控高甘油三酯血症性急性
2022年5月 胰腺炎肾损伤的机制研究[J]. 南京医科大学学报(自然科学版),2022,42(05):625-631 ·631 ·
al. Acute pancreatitis[J]. Lancet(London,England), renal proximal tubular cells via the PPARγ/CD36 path⁃
2020,396(10252):726-734 way in obese mice[J]. Int J Mol Sci,2021,22(22):12408
[3] YIN G,CANG X,YU G,et al. Different clinical presenta⁃ [18] RADA P,GONZÁLEZ ⁃ RODRÍGUEZ Á,GARCÍA ⁃
tions of hyperlipidemic acute pancreatitis:a retrospective MONZÓN C,et al. Understanding lipotoxicity in NAFLD
study[J]. Pancreas,2015,44(7):1105-1110 pathogenesis:is CD36 a key driver?[J]. Cell Death Dis,
[4] NAWAZ H,KOUTROUMPAKIS E,EASLER J,et al. Ele⁃ 2020,11(9):802
vated serum triglycerides are independently associated [19] SCHMIDT J,RATTNER D W,LEWANDROWSKI K,et
with persistent organ failure in acute pancreatitis[J]. Am al. A better model of acute pancreatitis for evaluating ther⁃
J Gastroenterol,2015,110(10):1497-1503 apy[J]. Ann Surg,1992,215(1):44-56
[5] YUAN L,ZHU L,ZHANG Y,et al. Effect of Da⁃Cheng⁃ [20] JABLONSKI P,HOWDEN B O,RAE D A,et al. An ex⁃
Qi decoction for treatment of acute kidney injury in rats perimental model for assessment of renal recovery from
with severe acute pancreatitis[J]. Chin Med,2018,13:38 warm ischemia[J]. Transplantation,1983,35(3):198-204
[6] ZUK A,BONVENTRE J V. Acute kidney injury[J]. An⁃ [21] SHARMIN M M,MIZUSAWA M,HAYASHI S,et al. Ef⁃
nu Rev Med,2016,67:293-307 fects of fatty acids on inducing endoplasmic reticulum
[7] REN J,BI Y,SOWERS J R,et al. Endoplasmic reticulum stress in bovine mammary epithelial cells[J]. J Dairy Sci,
stress and unfolded protein response in cardiovascular 2020,103(9):8643-8654
diseases[J]. Nat Rev Cardiol,2021,18(7):499-521 [22] WANG Y,ZHOU X,ZHAO D,et al. Berberine inhibits
[8] HETZ C,ZHANG K,KAUFMAN R J. Mechanisms,regu⁃ free fatty acid and LPS⁃induced inflammation via modulat⁃
lation and functions of the unfolded protein response[J]. ing ER stress response in macrophages and hepatocytes
Nat Rev Mol Cell Biol,2020,21(8):421-438 [J]. PloS One,2020,15(5):e0232630
[9] BOHNERT K R,MCMILLAN J D,KUMAR A. Emerging [23] HAO J W,WANG J,GUO H,et al. CD36 facilitates fatty
roles of ER stress and unfolded protein response path⁃ acid uptake by dynamic palmitoylation⁃regulated endocy⁃
ways in skeletal muscle health and disease[J]. J Cell tosis[J]. Nat Commun,2020,11(1):4765
Physiol,2018,233(1):67-78 [24] YANG X,ZHANG X,LIN Z,et al. Chaiqin chengqi decoc⁃
[10] HAN J,KAUFMAN R J. The role of ER stress in lipid me⁃ tion alleviates severe acute pancreatitis associated acute
tabolism and lipotoxicity[J]. J Lipid Res,2016,57(8): kidney injury by inhibiting endoplasmic reticulum stress
1329-1338 and subsequent apoptosis[J]. Biomed Pharmacother,
[11] WANG Y,YOU Y,TIAN Y,et al. PP04 ameliorates high⁃ 2020,125:110024
fat diet⁃induced hyperlipidemia by regulating lipid metab⁃ [25] PASCUAL I,SANAHUJA A,GARCÍA N,et al. Associa⁃
olism in C57BL/6N mice[J]. J Agric Food Chem,2020, tion of elevated serum triglyceride levels with a more se⁃
68(51):15154-15163 vere course of acute pancreatitis:Cohort analysis of 1457
[12] 刘牧林,何先弟,刘瑞林. 脂肪乳剂对重症胰腺炎患者 patients[J]. Pancreatology,2019,19(5):623-629
细胞因子的影响[J]. 中华全科医学,2005,3(6):479-480 [26] QIU M,LI S,JIN L,et al. Combination of chymostatin and
[13] GUO Y Y,LI H X,ZHANG Y,et al. Hypertriglyceridemia aliskiren attenuates ER stress induced by lipid overload
⁃ induced acute pancreatitis:progress on disease mecha⁃ in kidney tubular cells[J]. Lipids Health Dis,2018,17
nisms and treatment modalities[J]. Discov Med,2019,27 (1):183
(147):101⁃109 [27] GALLAZZINI M,PALLET N. Endoplasmic reticulum
[14] GHOSH A,GAO L,THAKUR A,et al. Role of free fatty stress and kidney dysfunction[J]. Biol Cell,2018,110
acids in endothelial dysfunction[J]. J Biomed Sci,2017, (9):205-216
24(1):50 [28] GRANDJEAN J M D,MADHAVAN A,CECH L,et al.
[15] MAI X,YIN X,CHEN P,et al. Salvianolic acid b protects Pharmacologic IRE1/XBP1s activation confers targeted
against fatty acid⁃induced renal tubular injury via inhibi⁃ ER proteostasis reprogramming[J]. Nat Chem Biol,2020,
tion of endoplasmic reticulum stress[J]. Front Pharma⁃ 16(10):1052-61
col,2020,11:574229 [29] ZHAO J,RUI H L,YANG M,et al. CD36⁃mediated lipid
[16] YANG X,OKAMURA D M,LU X,et al. CD36 in chronic accumulation and activation of NLRP3 inflammasome
kidney disease:novel insights and therapeutic opportuni⁃ lead to podocyte injury in obesity⁃related glomerulopathy
ties[J]. Nat Rev Nephrol,2017,13(12):769-781 [J]. Mediators Inflamm,2019,2019:3172647
[17] HUANG C C,CHOU C A,CHEN W Y,et al. Empa⁃ [收稿日期] 2022-03-19
gliflozin ameliorates free fatty acid induced⁃lipotoxicity in (本文编辑:唐 震)