Page 75 - 南京医科大学学报自然科学版

第43卷第3期 南京医科大学学报（自然科学版）
2023年3月 Journal of Nanjing Medical University（Natural Sciences） ·365 ·

·临床研究·

202例外周T细胞淋巴瘤临床特征分析及预后新模型建立

李文艺，申浩睿，汤 菁，梁金花，尹 华，王 莉，徐 卫 *
南京医科大学第一附属医院血液科，江苏 南京 210029

［摘 要］ 目的：外周 T 细胞淋巴瘤（peripheral T⁃cell lymphomas，PTCL）是一组异质性的非霍奇金淋巴瘤，本研究旨在探索
PTCL患者的临床特征，寻找影响无进展生存期（progression⁃free survival，PFS）和总生存期（overall survival，OS）的新指标，建立
新的预后模型。方法：回顾性分析2009年7月—2021年9月于南京医科大学第一附属医院就诊的202例PTCL患者的临床资
料，采用 Kaplan⁃Meier 法、单因素和多因素 Cox 回归分析等进行生存分析和预后因素评估。结果：所有 PTCL 患者中位 PFS 与
OS分别为11个月和43个月。血红蛋白（hemoglobin，Hb）正常患者的中位PFS（44个月vs. 9个月，P < 0.001）和中位OS（83个月
vs. 24个月，P=0.002）均优于Hb水平低于正常的患者。美国东部肿瘤协作组（Eastern Cooperative Oncology Group，ECOG）评分>
1（P=0.009）和Hb水平低于正常（P=0.007）是PFS的独立危险因素，年龄>60岁（P=0.015）和ECOG评分>1（P=0.002）是OS的独
立危险因素。Hb 水平联合国际预后指数（international prognostic index，IPI）和 T 细胞淋巴瘤预后指数（prognostic index
for T⁃cell lymphoma，PIT）评分提高了预测PFS的准确性。结论：Hb水平可以作为评估PTCL患者预后的指标，Hb水平联合IPI
和PIT可以提高预测PTCL患者预后的准确性。
［关键词］ 外周T细胞淋巴瘤；血红蛋白；预后；生存
［中图分类号］ R733.4 ［文献标志码］ A ［文章编号］ 1007⁃4368（2023）03⁃365⁃06
doi：10.7655/NYDXBNS20230310

Analysis of clinical characteristics and establishment of a new prognostic model in 202
cases with peripheral T⁃cell lymphomas

*
LI Wenyi，SHEN Haorui，TANG Jing，LIANG Jinhua，YIN Hua，WANG Li，XU Wei
Department of Hematology，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China

［Abstract］ Objective：Peripheral T⁃cell lymphomas（PTCL）is a heterogeneous group of non⁃Hodgkin’s lymphomas. The current
study aims to analyze the clinical features of PTCL patients，and explore new factors that affected the progression⁃free survival（PFS）

and overall survival（OS），with which to establish new prognostic models. Methods：The clinical data of 202 patients with PTCL from
the First Affiliated Hospital of Nanjing Medical University between July 2009 and September 2021 were retrospectively analyzed.
Kaplan ⁃ Meier method，univariate and multivariate Cox regression analysis were performed for the survival analysis and prognostic
factor evaluation. Results：The median PFS and OS of all PTCL patients were 11 months and 43 months respectively. Patients with
lower level of hemoglobin（Hb）showed shorter PFS（9 months vs. 44 months，P < 0.001）and OS（24 months vs. 83 months，P=0.002）
than patients with normal level of Hb. The ECOG scores >1（P=0.009）and lower Hb level（P=0.007）were independent risk factors for
PFS. Age >60 years（P=0.015）and the ECOG score >1（P=0.002）were independent risk factors for OS. International prognostic index
（IPI）or prognostic index for T⁃cell lymphoma（PIT）combined with the Hb level improved the accuracy of predicting PFS of patients
with PTCL. Conclusion：The level of Hb may be a good candidate for predicting prognosis of patients with PTCL. The Hb level
combined with IPI and PIT can improve the ability to predict prognosis of patients with PTCL.
［Key words］ peripheral T⁃cell lymphoma；hemoglobin；prognosis；survival
［J Nanjing Med Univ，2023，43（03）：365⁃370］

［基金项目］ 国家自然科学基金（81770166）
∗
通信作者（Corresponding author），E⁃mail：xuwei10000@hotmail.com