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南京医科大学学报(自然科学版)                                  第44卷第3期
               ·380 ·                     Journal of Nanjing Medical University(Natural Sciences)   2024年3月


             ·影像医学研究·

              二维斑点追踪技术联合实时三维超声心动图评价肥胖对原发

              性高血压患者左房功能的影响



              相三婷 ,王文平 ,雍永宏 ,孙 伟 ,张盼盼 ,童梦佳 ,陈                       璐  3
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               南京医科大学附属江宁医院超声诊断科,江苏                 南京   211100;南京医科大学第一附属医院心内科,江苏                南京   210029;
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               南京医科大学附属江宁医院心内科,江苏 南京 211100
             [摘    要] 目的:联合应用二维斑点追踪技术(two⁃dimensional speckle tracking imaging,2D⁃STI)和实时三维超声心动图
             (real⁃time three⁃dimensional echocardiography,RT⁃3DE)评估肥胖对原发性高血压患者左房功能的影响。方法:根据体重指数
             (body mass index,BMI)将2022年4月—2023年7月在南京医科大学附属江宁医院确诊的132例原发性高血压患者及114例血压
              正常的健康对照分为 6 个亚组。利用 2D⁃STI 联合 RT⁃3DE 技术获得左房纵向应变及机械功能指数,比较各组间左房功能差
              异。结果:与相同 BMI 分类的健康对照组相比,高血压组左房储备期应变(left artial reservoir strain,LASr)、左房导管期应变
             (left artial conduit strain,LAScd)均下降(P < 0.05);随BMI增加,高血压组LASr、LAScd、左房总排空分数(total left atrial ejection
              fraction,LAEFt)、左房被动排空分数(passive left atrial ejection fraction,LAEFp)、左房主动排空分数(active left a trial ejection
              fraction,LAEFa)均降低(P < 0.05),而左房收缩期应变(left artial contractile strain,LASct)无明显差异(P > 0.05)。多元线性回
              归显示BMI与高血压组LASr、LAScd、LAEFt、LAEFp、LAEFa均呈独立负相关(P < 0.05),而收缩压与高血压患者左房功能无明显
              相关(P > 0.05)。结论:高血压可引起左房功能受损,随着BMI的增加特别是合并肥胖后可在一定程度上进一步加重功能损伤。
             [关键词] 左房功能;二维斑点追踪技术;高血压;肥胖;实时三维超声心动图
             [中图分类号] R540.45                    [文献标志码] A                      [文章编号] 1007⁃4368(2024)03⁃380⁃07
              doi:10.7655/NYDXBNSN230852



              Evaluation of the effect of obesity on left atrial function in patients with essential
              hypertension using two⁃dimensional speckle tracking imaging combined with real⁃time three⁃
              dimensional echocardiography

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              XIANG Santing ,WANG Wenping ,YONG Yonghong ,SUN Wei ,ZHANG Panpan ,TONG Mengjia ,CHEN Lu     3
              1 Department of Ultrasound,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing 211100;
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              2 Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;Department
              of Cardiology,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing 211100,China
             [Abstract] Objective:To evaluate the effect of obesity on left atrial function in patients with essential hypertension by using a
              combined approach of two⁃dimensional speckle tracking imaging(2D⁃STI)and real⁃time three⁃dimensional echocardiography(RT⁃
              3DE). Methods:A total of 132 patients diagnosed with essential hypertension and 114 controls with normal blood pressure were
              enrolled from Jiangning Hospital Affiliated to Nanjing Medical University from April 2022 to July 2023. According to the body mass
              index(BMI),they were stratified into six subgroups. Left atrial longitudinal strain and mechanical function indices were obtained using
              the combined 2D⁃STI and RT⁃3DE techniques to compare differences in left atrial function among the groups. Results:Compared to
              the healthy control group with the same BMI category,the hypertension group showed a decrease in left atrial reservoir strain(LASr)
              and left atrial conduit strain(LAScd)(P < 0.05);As BMI increased,LASr,LAScd,total left atrial ejection fraction(LAEFt),passive
              left atrial positive ejection fraction(LAEFp),and active left atrial ejection fraction(LAEFa)decreased in hypertension patients(P <
              0.05),while left atrial contractile strain(LASct)showed no significant difference(P > 0.05). Multivariate linear regression analysis

             [基金项目] 国家自然科学基金(82270362);南京市江宁区科技局惠民发展计划(2022103S)
              ∗
              通信作者(Corresponding author),E⁃mail:xwjnyycsk@163.com
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