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               ·534 ·                            南 京    医 科 大 学 学         报                        2024年4月


                   enhances glucose ⁃ derived de novo serine biosythseis to  gy in combating cancer[J]. BioFactors,2022,48(2):
                   promote gliblastoma growth[J]. J Exp Clin Cancer Res,  359-383
                   2023,42(1):340                               [49]ZHAO F Y,YANG G,QIU J D,et al. HIF⁃1α⁃regulated
             [38]FAN K,FAN Z Y,CHENG H,et al. Hexokinase 2 dimeri⁃   stanniocalcin⁃ 1 mediates gemcitabine resistance in pan⁃
                   zation and interaction with voltage⁃dependent anion chan⁃  creatic ductal adenocarcinoma via PI3K/AKT signaling
                   nel promoted resistance to cell apoptosis induced by gem⁃  pathway[J]. Mol Carcinog,2022,61(9):839-850
                   citabine in pancreatic cancer[J]. Cancer Med,2019,8  [50]XI Y,YUAN P,LI T,et al. hENT1 reverses chemoresis⁃
                  (13):5903-5915                                     tance by regulating glycolysis in pancreatic cancer[J].
             [39]XIE P,TAN S Y,LI H F,et al. Transcriptome data⁃based  Cancer Lett,2020,479:112-122
                   status of PI3K/AKT/mTOR pathway indicates heterogene⁃  [51]LIU Y,GU Y J,NG S,et al. Circulating levels of hydroxyl⁃
                   ity and immune modulation in patients with pancreatic  ated bradykinin function as an indicator of tissue HIF⁃1α
                   ductal adenocarcinoma[J]. J Gene Med,2024,26(1):  expression[J]. Sci Bull,2020,65(18):1570-1579
                   e3570                                        [52]SHUKLA S K,PUROHIT V,MEHLA K,et al. MUC1 and
             [40]CHENG L,QIN T,MA J G,et al. Hypoxia⁃inducible factor⁃  HIF⁃1alpha signaling crosstalk induces anabolic glucose
                   1α mediates hyperglycemia ⁃ induced pancreatic cancer  metabolism to impart gemcitabine resistance to pancreatic
                   glycolysis[J]. Anticancer Agents Med Chem,2019,19  cancer[J]. Cancer Cell,2017,32(3):392
                  (12):1503-1512                                [53]XU F Y,HUANG M Q,CHEN Q Y,et al. LncRNA HIF1A⁃
             [41]PENNY H L,SIEOW J L,ADRIANI G,et al. Warburg me⁃    AS1 promotes gemcitabine resistance of pancreatic can⁃
                   tabolism in tumor⁃conditioned macrophages promotes me⁃  cer by enhancing glycolysis through modulating the AKT/
                   tastasis in human pancreatic ductal adenocarcinoma[J].  YB1/HIF1α pathway[J]. Cancer Res,2021,81(22):
                   Onco Immunology,2016,5(8):e1191731                5678-5691
             [42]OZCAN S C,SARIOGLU A,ALTUNOK T H,et al.        [54]GAO C T,LI S S,ZHAO T S,et al. SCF,regulated by HIF⁃
                   PFKFB2 regulates glycolysis and proliferation in pancre⁃  1α,promotes pancreatic ductal adenocarcinoma cell pro⁃
                   atic cancer cells[J]. Mol Cell Biochem,2020,470(1/2):  gression[J]. PLoS One,2015,10(3):e0121338
                   115-129                                      [55]YING H Q,KIMMELMAN A C,LYSSIOTIS C A,et al.
             [43]MINCHENKO O H,TSUCHIHARA K,MINCHENKO D O,           Oncogenic KRAS maintains pancreatic tumors through
                   et al. Mechanisms of regulation of PFKFB expression in  regulation of anabolic glucose metabolism[J]. Cell,2012,
                   pancreatic and gastric cancer cells[J]. World J Gastroen⁃  149(3):656-670
                   terol,2014,20(38):13705-13717                [56]LI Y G,TANG S J,SHI X H,et al. Metabolic classifica⁃
             [44]LI H M,YANG J G,LIU Z J,et al. Blockage of glycolysis  tion suggests the GLUT1/ALDOB/G6PD axis as a therapeu⁃
                   by targeting PFKFB3 suppresses tumor growth and metas⁃  tic target in chemotherapy⁃resistant pancreatic cancer[J].
                   tasis in head and neck squamous cell carcinoma[J]. J  Cell Rep Med,2023,4(9):101162
                   Exp Clin Cancer Res,2017,36(1):7             [57]LI X J,JIANG Y H,MEISENHELDER J,et al. Mitochon⁃
             [45]CHRISTOFK H R,VANDER HEIDEN M G,HARRIS M H,         dria⁃translocated PGK1 functions as a protein kinase to co⁃
                   et al. The M2 splice isoform of pyruvate kinase is impor⁃  ordinate glycolysis and the TCA cycle in tumorigenesis[J].
                   tant for cancer metabolism and tumour growth[J]. Nature,  Mol Cell,2016,61(5):705-719
                   2008,452(7184):230-233                       [58]WU D H,LIANG H,LU S N,et al. MiR⁃124 suppresses
             [46]CALABRETTA S,BIELLI P,PASSACANTILLI I,et al.        pancreatic ductal adenocarcinoma growth by regulating
                   Modulation of PKM alternative splicing by PTBP1 pro⁃  monocarboxylate transporter 1 ⁃ mediated cancer lactate
                   motes gemcitabine resistance in pancreatic cancer cells[J].  metabolism[J]. Cell Physiol Biochem,2018,50(3):924-
                   Oncogene,2016,35(16):2031-2039                    935
             [47]FENG J K,MA T L,GE Z J,et al. PKM2 gene regulates  [59]KONG S C,NØHR ⁃ NIELSEN A,ZEEBERG K,et al.
                   the behavior of pancreatic cancer cells via mitogen⁃acti⁃  Monocarboxylate transporters MCT1 and MCT4 regulate
                   vated protein kinase pathways[J]. Mol Med Rep,2015,11  migration and invasion of pancreatic ductal adenocarcino⁃
                  (3):2111-2117                                      ma cells[J]. Pancreas,2016,45(7):1036-1047
             [48]KOOSHKI L,MAHDAVI P,FAKHRI S,et al. Targeting  [60]KAWADA K,TODA K,SAKAI Y. Targeting metabolic re⁃
                   lactate metabolism and glycolytic pathways in the tumor  programming in KRAS⁃driven cancers[J]. Int J Clin On⁃
                   microenvironment by natural products:a promising strate⁃  col,2017,22(4):651-659
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