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第44卷第4期               喻 悦,王瑜亮,张 晓. 葡萄糖代谢重编程在胰腺癌耐药中的研究进展[J].
                  2024年4月                   南京医科大学学报(自然科学版),2024,44(04):524-535,572                     ·535 ·


               [61]SANTANA⁃CODINA N,ROETH A A,ZHANG Y,et al.           9949272
                    Oncogenic KRAS supports pancreatic cancer through regu⁃  [73]QIN C,YANG G,YANG J S,et al. Metabolism of pancre⁃
                    lation of nucleotide synthesis[J]. Nat Commun,2018,9  atic cancer:paving the way to better anticancer strategies[J].
                   (1):4945                                            Mol Cancer,2020,19(1):50
               [62]SAEUI C T,SHAH S R,FERNANDEZ⁃GIL B I,et al.   [74]SUN L ,CAO J,CHEN K,et al. Betulinic acid inhibits
                    Anticancer properties of hexosamine analogs designed to  stemness and EMT of pancreatic cancer cells via activa⁃
                    attenuate metabolic flux through the hexosamine biosyn⁃  tion of AMPK signaling[J]. Int J Oncol,2019,54(1):98-
                    thetic pathway[J]. ACS Chem Biol,2023,18(1):151-165  110
               [63]LIU C,DENG S M,XIAO Z W,et al. Glutamine is a sub⁃  [75]ZHAO H Q,WU S H,LI H H,et al. ROS/KRAS/AMPK
                    strate for glycosylation and CA19⁃9 biosynthesis through  signaling contributes to gemcitabine ⁃ induced stem ⁃ like
                    hexosamine biosynthetic pathway in pancreatic cancer[J].  cell properties in pancreatic cancer[J]. Mol Ther Oncoly⁃
                    Discov Oncol,2023,14(1):20                         tics,2019,14:299-312
               [64]RICCIARDIELLO F,GANG Y,PALORINI R,et al. Hexo⁃  [76]KABASHIMA A,MATSUO Y,ITO S,et al. cGAS⁃STING
                    samine pathway inhibition overcomes pancreatic cancer  signaling encourages immune cell overcoming of fibro⁃
                    resistance to gemcitabine through unfolded protein re⁃  blast barricades in pancreatic cancer[J]. Sci Rep,2022,
                    sponse and EGFR ⁃ Akt pathway modulation[J]. Onco⁃  12(1):10466
                    gene,2020,39(20):4103-4117                   [77]JACOBERGER F C,COUSINEAU I,BARECHE Y,et al.
               [65]JU H Q,ZHUANG Z N,LI H,et al. Regulation of the     CD73 inhibits cGAS⁃STING and cooperates with CD39 to
                    Nampt⁃mediated NAD salvage pathway and its therapeu⁃  promote pancreatic cancer[J]. Cancer Immunol Res,
                    tic implications in pancreatic cancer[J]. Cancer Lett,  2023,11(1):56-71
                    2016,379(1):1-11                             [78]KOSAKA A,YAJIMA Y,YASUDA S,et al. Celecoxib pro⁃
               [66]SHARMA N,BHUSHAN A,HE J,et al. Metabolic plasticity  motes the efficacy of STING⁃targeted therapy by increas⁃
                                                                                    +
                    imparts erlotinib⁃resistance in pancreatic cancer by up⁃  ing antitumor CD8 T⁃cell functions via modulating glu⁃
                                                                                          +
                                                                                               +
                    regulating glucose⁃6⁃phosphate dehydrogenase[J]. Can⁃  cose metabolism of CD11b Ly6G cells[J]. Int J Cancer,
                    cer Metab,2020,8:19                                2023,152(8):1685-1697
               [67]DENG J Y,GUO Y J,HU X M,et al. High glucose pro⁃  [79]RAJESHKUMAR N V,YABUUCHI S,PAI S G,et al.
                    motes pancreatic ductal adenocarcinoma gemcitabine re⁃  Treatment of pancreatic cancer patient⁃derived xenograft
                    sistance and invasion through modulating ROS/MMP ⁃ 3  panel with metabolic inhibitors reveals efficacy of phen⁃
                    signaling pathway[J]. Oxid Med Cell Longev,2022,   formin[J]. Clin Cancer Res,2017,23(18):5639-5647
                    2022:3243647                                 [80]RAEZ L E,PAPADOPOULOS K,RICART A D,et al. A
               [68]KIM M J,KIM H S,KANG H W,et al. SLC38A5 modu⁃       phase I dose⁃escalation trial of 2⁃deoxy⁃D⁃glucose alone
                    lates ferroptosis to overcome gemcitabine resistance in  or combined with docetaxel in patients with advanced solid
                    pancreatic cancer[J]. Cells,2023,12(20):2509       tumors[J]. Cancer Chemother Pharmacol,2013,71(2):
               [69]MOSSMANN D,PARK S,HALL M N. mTOR signalling         523-530
                    and cellular metabolism are mutual determinants in can⁃  [81]PHILIP P A,BUYSE M E,ALISTAR A T,et al. A Phase
                    cer[J]. Nat Rev Cancer,2018,18(12):744-757         Ⅲ open ⁃ label trial to evaluate efficacy and safety of
               [70]LIN M M,XIAO Y Y,DAI Y L,et al. Chloroxine inhibits  CPI ⁃ 613 plus modified FOLFIRINOX(mFFX)versus
                    pancreatic cancer progression through targeted antago⁃  FOLFIRINOX(FFX)in patients with metastatic adeno⁃
                    nization of the PI3K/AKT/mTOR signaling pathway[J/  carcinoma of the pancreas[J]. Future Oncol,2019,15
                    OL]. Clin Transl Oncol,2023[2023 ⁃ 11 ⁃ 10]. DOI:  (28):3189-3196
                    10.1007/s12094⁃023⁃03328⁃w                   [82]ALISTAR A,MORRIS B B,DESNOYER R,et al. Safety
               [71]ALLEN E,MIÉVILLE P,WARREN C M,et al. Metabolic      and tolerability of the first⁃in⁃class agent CPI⁃613 in com⁃
                    symbiosis enables adaptive resistance to anti⁃angiogenic  bination with modified FOLFIRINOX in patients with
                    therapy that is dependent on mTOR signaling[J]. Cell  metastatic pancreatic cancer:a single⁃centre,open⁃label,
                    Rep,2016,15(6):1144-1160                           dose⁃escalation,phase 1 trial[J]. Lancet Oncol,2017,18
               [72]MA Z Y,LI Z C,MA Z G,et al. Development of a KRAS⁃  (6):770-778
                    associated metabolic risk model for prognostic prediction  [83]BACHET J B,GAY F,MARÉCHAL R,et al. Asparagine
                    in pancreatic cancer[J]. Biomed Res Int,2021,2021:                           (下转第572页)
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