Page 131 - 南京医科大学自然版

第44卷第5期 南京医科大学学报（自然科学版）
2024年5月 Journal of Nanjing Medical University（Natural Sciences） ·719 ·

·综 述·

骨骼肌肌间脂肪浸润在代谢相关疾病中的研究进展

刘 竞，丁国宪 *
南京医科大学第一附属医院老年内分泌科，江苏 南京 210029

［摘 要］ 伴随着人类疾病谱的改变，肥胖及其并发症已成为重要的健康危险因素。在正常生理状态下，骨骼肌中存在一定
量的脂滴，这被称为肌间脂肪。然而，当机体肥胖时，脂滴的生成速率超过消耗，导致脂肪组织的存储能力超负荷，进而引发异
位脂肪沉积。这种肌间脂肪的过度积累会严重干扰骨骼肌的正常功能，并在肌少症、肥胖及糖尿病的发生和发展过程中发挥
关键作用。尽管肌间脂肪浸润在肥胖及相关代谢性疾病中的重要性已得到广泛认可，但其具体的调控机制尚不明确。因此，
探索新的策略和方法以改善肌间脂肪浸润的状况，不仅有助于更深入理解这些疾病的发病机制，还可能为治疗上述疾病提供
全新的视角和思路。文章全面阐述了肌间脂肪组织的生理功能，以及在病理状态下导致肌间脂肪浸润的机制。同时，对目前
对肌间脂肪浸润干预手段的研究进展进行综述，以期为治疗与肌间脂肪浸润相关的临床疾病提供潜在的治疗策略和方法。
［关键词］ 肌间脂肪组织；肥胖；胰岛素抵抗；衰弱；肌少症；2型糖尿病
［中图分类号］ R589 ［文献标志码］ A ［文章编号］ 1007⁃4368（2024）05⁃719⁃07
doi：10.7655/NYDXBNSN231155

Research progress on skeletal muscle intramuscular fat infiltration in metabolic ⁃ related
diseases

LIU Jing，DING Guoxian *
Department of Gerontoendocrinology，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，
China

［Abstract］ With changes of human disease spectrum，obesity and its complications have become important health risk factors. Under
normal physiological conditions，there is a certain amount of lipid droplets in skeletal muscle，known as intramuscular fat. However，
when the body becomes obese，the rate of lipid droplet generation exceeds consumption，leading to the overload of adipose tissue and
resulting in ectopic fat deposition. This excessive accumulation of intramuscular fat severely disrupts the normal function of skeletal
muscle and plays an important role in the occurrence and development of sarcopenia，obesity and diabetes. Although the importance of
intramuscular fat infiltration in obesity and related metabolic diseases is widely recognized，its specific regulatory mechanism remains
unclear. Therefore，exploring new strategies and methods to improve intramuscular fat infiltration not only helps us to better understand
the pathogenesis of these diseases but also provide new perspectives for the treatment of these diseases. The core content of this article
lies in comprehensively elucidating the physiological functions of intramuscular fat tissue and the mechanisms leading to intramuscular
fat infiltration under pathological conditions. Additionally，the research progress on the intervention for intramuscular fat infiltration is
reviewed，aiming to provide potential therapeutic strategies for the treatment of clinical diseases related to intramuscular fat infiltration.
［Key words］ intramuscular fat tissue；obesity；insulin resistance；frailty；sarcopenia；type 2 diabetes mellitus
［J Nanjing Med Univ，2024，44（05）：719⁃725］

随着社会进步和人类生活方式的演变，肥胖及
其相关并发症的患病率呈现出快速上升的趋势。
［基金项目］ 国家重点研发计划（2022YFA0806100）；国家自
然科学基金（82201740） 据预测，到2025年全球将有18%的男性和25%的女
［1］
∗ 性迈入肥胖症行列 。肥胖状态下，体内脂肪的增
通信作者（Corresponding author），E⁃mail：dinggx@njmu.edu.cn