Page 35 - 南京医科大学自然版

第44卷第7期 苏思璇，尚彦星，段程伟，等. 基于生信分析对脓毒症相关性脑病中神经炎症相关核心基因
2024年7月 的筛选［J］. 南京医科大学学报（自然科学版），2024，44（7）：915-926 ·919 ·

A 1.0 B
1 200
★ β=7，R =0.86 1 100
0.8
Scale free topology model R 2 signed fit， -0.2 Mean connectivity 1 000
2
0.6
900
0.4
800
700
0.2
600
0.0
500
400
300
-0.4
-0.6
100
-0.8 200 0 ★ β=7，14.59
2 4 5 6 10 12 14 16 18 20 22 24 26 28 30 2 4 5 6 10 12 14 16 18 20 22 24 26 28 30
Soft⁃threshold（power） Soft⁃threshold（power）
C D
1.0 Correlation coefficient P value
0.9
-0.5 0 0.5 00 0.05 0.10
Height 0.8 0.12 7.3e -0.12 7.3e -4 -6 Dark olivegreen
-4
6.3e -0.16
0.16
-6
6.3e
Dark orange
0.7
0.50
0.45 2.9e -51 -0.50 2.9e -51 Brown
-41 -0.45
-41
6.3e
6.3e
White
0.6
0.15 1.3e -0.15 1.3e -5 Magenta
-5
0.18 4.6e -0.18 4.6e -7 Light cyan
-7
0.5
-0.24 2.4e -12 0.24 2.4e -12 Dark grey
0.15 2.3e -0.15 2.3e -5 Cyan
-5
0.4
0.34 1.1e -23 -0.34 1.1e -23 Dark red
Dynamic tree cut
-0.17 7.3e -7 0.17 7.3e -7 Blue
Merge dynamic -0.23 3.9e -11 0.23 3.9e -11 Purple
0.26 4.0e -14 -0.26 4.0e -14 Salmon
-0.10 5.2e -3 0.10 5.2e -3 Grey60
0.30 1.2e -18 -0.30 1.2e -18 Yellow
-0.43 4.0e -38 0.43 4.0e -38 Black
-0.38 8.3e -29 0.38 8.3e -29 Orange
-0.12 4.5e -4 0.12 4.5e -4 Paleturquoise
-0.29 3.3e -17 0.29 3.3e -17 Steel blue
-0.18 2.4e -7 0.18 2.4e -7 Royal blue
-0.36 1.2e -25 0.36 1.2e -25 Sky blue
-5
0.15 1.9e -0.15 -5 Grey
E 1.9e
0.15 Control group Sepsis group
Height 0.10
0.05
0
Salmon Distance F
Yellow
Brown P=4.3e-1.04，r=0.72
White .0 0.5 1.0 1.5
Magenia 1.0
Cyan
Lighte yan
Dark red 0.5
Grey60 Gene significances of group
Sky blue
Black 0.0
Orange
Royal blue -0.5
Paleturquoise
Steel blue
Dark olivegrccn -0.5 0 0.5 1.0 1.5
Dark orange Module membership in brown module
Dark grey
Grey
Blue
Purple
Salmon Yellow Brown White Magenia Cyan Lighte yan Dark red Grey60 Sky blue Black Orange Royal blue Paleturquoise Steel blue Dark olivegrccn Dark orange Dark grey Grey Blue Purple
A：Network topology analysis. The x⁃axis represents the soft⁃threshold power，and the y⁃axis represents the fitting index of the scale⁃free topology
model. B：Network topology analysis. The x⁃axis represents the soft⁃threshold power，and the y⁃axis represents the average connectivity. C：Clustering
dendrogram of genes. D：Clustering heatmap of module feature vectors. E：Correlation analysis between modules and sepsis. Each module contains corre⁃
sponding correlations and P values. F：The relevance of genes in the brown module with sepsis.
图1 WGCNA分析脓毒症数据集GSE65682
Figure 1 WGCNA analysis of sepsis dataset GSE65682