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南京医科大学学报(自然科学版) 第44卷第10期
·1428 · Journal of Nanjing Medical University(Natural Sciences) 2024年10月
·综 述·
PET/MRI在头颈部肿瘤中的应用价值
陈萌萌,高珂梦,沈 楠,唐立钧,李天女 *
南京医科大学第一附属医院核医学科,江苏 南京 210029
[摘 要] 头颈部肿瘤是常见的恶性肿瘤之一,多数患者确诊时已处于疾病中晚期,因此头颈部肿瘤的早期诊断、准确分期及
疗效监测是优化治疗策略及改善预后的关键。一体化正电子发射断层扫描/磁共振成像(positron emission tomography/magnetic
resonance imaging,PET/MRI)整合了分子功能与解剖结构成像,实现了PET与MRI的优势互补,将PET代谢功能信息与MRI良
好软组织对比度相结合,真正实现多模态成像,在肿瘤诊疗过程中具有重要临床意义。文章主要探讨PET/MRI在头颈部肿瘤
诊断分期、监测疗效、预测预后及制定放疗计划等方面的应用及进展。
[关键词] 头颈部肿瘤;PET/MRI;F⁃FDG;疗效评估
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[中图分类号] R814.42 [文献标志码] A [文章编号] 1007⁃4368(2024)10⁃1428⁃07
doi:10.7655/NYDXBNSN240287
Application value of PET/MRI in head and neck cancer
CHEN Mengmeng,GAO Kemeng,SHEN Nan,TANG Lijun,LI Tiannü *
Department of Nuclear Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China
[Abstract] Head and neck cancer is one of the common malignant tumors,and most patients are diagnosed in the middle or late
stages of the disease. Therefore,early diagnosis,accurate staging,and efficacy monitoring are the key to optimizing treatment strategies
and improving prognosis of head and neck cancer. Integrated positron emission tomography/magnetic resonance imaging(PET/MRI)
combines molecular function and anatomical structure imaging,harnessing the complementary advantages of PET and MRI. By
combining the metabolic information of PET with the excellent soft tissue contrast of MRI,it truly achieves multimodal imaging,which
is of significant clinical importance in the diagnosis,treatment,and monitoring of tumors. This review mainly focuses on the application
and progress of PET/MRI in the diagnosis,staging,monitoring of efficacy,prognosis prediction,and development of radiotherapy plans
for head and neck cancer.
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[Key words] head and neck cancer;PET/MRI;F⁃FDG;assessment of efficacy
[J Nanjing Med Univ,2024,44(10):1428⁃1434]
头颈部肿瘤(head and neck cancer,HNC)指发 软组织对比度欠佳,二者均无法充分显示病灶受累
生于口腔颌面、咽、喉、鼻腔及鼻窦等部位的恶性肿 范围,因此在HNC早期诊断及临床分期等方面存在
[1]
瘤 ,病理类型大多是鳞癌,是常见恶性肿瘤,每年 局限。相比之下,一体化正电子发射断层扫描/磁共
新增病例超 66 万例,死亡病例超 32.5 万例 [2-3] 。近 振成像(positron emission tomography/magnetic reso⁃
年来,正电子发射断层扫描/计算机断层扫描(posi⁃ nance imaging,PET/MRI)将分子功能与解剖结构成
tron emission tomography/computed tomography,PET/ 像相结合,兼具 PET 与 MRI 的优点,且为非侵入性
CT)广泛应用于HNC ,但PET的分辨率较低,CT的 检查,为揭示肿瘤的异质性及反映治疗变化提供了
[4]
新思路。此外,已有研究显示,一体化 PET/MRI 有
助于准确预测 HNC 的病理分化程度 及表皮生长
[5]
[基金项目] 国家卫生健康委核医学重点实验室;江苏省分
子核医学重点实验室项目(KF202206) 因子受体(epidermal growth factor receptor,EGFR)表
∗ 达水平 [6-7] ,为个体化治疗提供了重要信息。本文主
通信作者(Corresponding author),E⁃mail: litiannv@126.com

