Page 110 - 南京医科大学自然版

第44卷第10期
·1426 · 南 京 医 科 大 学 学 报 2024年10月

-/-
ApoE mice［J］. Int J Cardiol，2018，265：181-187 ［28］FORRAT R，SEBBAG L，WIERNSPERGER N，et al.
［16］ ZHANG Y Q，MEI H L，CHANG X A，et al. Adipocyte⁃ Acute myocardial infarction in dogs with experimental
derived microvesicles from obese mice induce M1 macro⁃ diabetes［J］. Cardiovasc Res，1993，27（11）：1908-1912
phage phenotype through secreted miR ⁃ 155［J］. J Mol ［29］ ANNAPURNA A，CHALLA S R，PRAKASH G J，et al.
Cell Biol，2016，8（6）：505-517 Therapeutic potential of sulindac against ischemia⁃reper⁃
［17］XU X Y，GRIJALVA A，SKOWRONSKI A，et al. Obesity fusion⁃induced myocardial infarction in diabetic and non⁃
activates a program of lysosomal⁃dependent lipid metabo⁃ diabetic rats［J］. Exp Clin Cardiol，2008，13（2）：66-70
lism in adipose tissue macrophages independently of clas⁃ ［30］ZHAO H，CHEN X Y，HU G Y，et al. Smallextracellular
sic activation［J］. Cell Metab，2013，18（6）：816-830 vesicles from brown adipose tissue mediate exercise car⁃
［18］YU Q，WANG D X，WEN X T，et al. Adipose⁃derived exo⁃ dioprotection［J］. Circ Res，2022，130（10）：1490-1506
somes protect the pulmonary endothelial barrier in venti⁃ ［31］WEN Z Y，LI J F，FU Y L，et al. Hypertrophicadipocyte⁃
lator ⁃ induced lung injury by inhibiting the TRPV4/Ca 2 + derived exosomal miR⁃802⁃5p contributes to insulin resis⁃
signaling pathway［J］. Am J Physiol Lung Cell Mol Physi⁃ tance in cardiac myocytes through targeting HSP60［J］.
ol，2020，318（4）：L723-L741 Obesity，2020，28（10）：1932-1940
［19］ ZHAO Y，ZHAO M F，JIANG S，et al. Liver governs ［32］LIN H，CHEN X N，PAN J N，et al. Secretion of miRNA⁃
adipose remodelling via extracellular vesicles in response 326 ⁃ 3p by senescent adipose exacerbates myocardial
to lipid overload［J］. Nat Commun，2020，11（1）：719 metabolism in diabetic mice［J］. J Transl Med，2022，20
［20］KOECK E S，IORDANSKAIA T，SEVILLA S，et al. Adi⁃ （1）：278
pocyte exosomes induce transforming growth factor beta ［33］LI F Q，ZHANG K K，XU T，et al. Exosomal microRNA⁃
pathway dysregulation in hepatocytes：a novel paradigm 29a mediates cardiac dysfunction and mitochondrial inac⁃
for obesity⁃related liver disease［J］. J Surg Res，2014，192 tivity in obesity⁃related cardiomyopathy［J］. Endocrine，
（2）：268-275 2019，63（3）：480-488
［21］GAO J，LI X Y，WANG Y，et al. Adipocyte⁃derived extra⁃ ［34］NIE H，PAN Y，ZHOU Y W. Exosomal microRNA⁃ 194
cellular vesicles modulate appetite and weight through causes cardiac injury and mitochondrial dysfunction in
mTOR signalling in the hypothalamus［J］. Acta Physiol， obese mice［J］. Biochem Biophys Res Commun，2018，
2020，228（2）：e13339 503（4）：3174-3179
［22］ KRANENDONK M E，VISSEREN F L，VAN HER⁃ ［35］ GAN L ，XIE D N ，LIU J ，et al. Smallextracellular
WAARDEN J A，et al. Effect of extracellular vesicles of microvesicles mediated pathological communications
human adipose tissue on insulin signaling in liver and between dysfunctional adipocytes and cardiomyocytes as
muscle cells［J］. Obesity，2014，22（10）：2216-2223 a novel mechanism exacerbating ischemia/reperfusion
［23］ MAN W R，SONG X L，XIONG Z Y，et al. Exosomes injury in diabetic mice［J］. Circulation，2020，141（12）：
derived from pericardial adipose tissues attenuate cardiac 968-983
remodeling following myocardial infarction by adipsin ⁃ ［36］REN C L，CHEN H，XIE Y Q. Letter by Ren，et al. regard⁃
regulated iron homeostasis［J］. Front Cardiovasc Med， ing article，“smallextracellular microvesiclesmediated
2022，9：1003282 pathological communications between dysfunctional adi⁃
［24］SHAIHOV⁃TEPER O，RAM E，BALLAN N，et al. Extra⁃ pocytes and cardiomyocytes as a novel mechanism exacer⁃
cellularvesicles from epicardial fat facilitate atrial fibrilla⁃ bating ischemia/reperfusion injury in diabetic mice”［J］.
tion［J］. Circulation，2021，143（25）：2475-2493 Circulation，2020，142（7）：e97-e98
［25］BABES E E，BUSTEA C，BEHL T，et al. Acute coronary ［37］LI Y X，DING F Z，SHEN Z Y. Letter by Li，et al regard⁃
syndromes in diabetic patients，outcome，revasculariza⁃ ing article，“smallextracellular microvesiclesmediated
tion，and antithrombotic therapy［J］. Biomedecine Phar⁃ pathological communications between dysfunctional adi⁃
macother，2022，148：112772 pocytes and cardiomyocytes as a novel mechanism exacer⁃
［26］ ELTZSCHIG H K，ECKLET. Ischemia and reperfusion ⁃ bating ischemia/reperfusion injury in diabetic mice”［J］.
from mechanism to translation［J］. Nat Med，2011，17 Circulation，2020，142（7）：e95-e96
（11）：1391-1401 ［38］PAN Y，HUI X Y，HOO R L C，et al. Adipocyte⁃secreted
［27］ HEKIMIAN G，KHANDOUDI N，FEUVRAY D，et al. exosomal microRNA⁃34a inhibits M2 macrophage polariza⁃
Abnormal cardiac rhythm in diabetic rats［J］. Life Sci， tion to promote obesity⁃induced adipose inflammation［J］.

1985，37（6）：547-551 J Clin Invest，2019，129（2）：834-849