Page 147 - 南京医科大学自然版
P. 147
第45卷第11期 张 铭,冯晓东,潘 蕊. 中医药调控神经血管单元及其标志物改善阿尔茨海默病的研究进展[J].
2025年11月 南京医科大学学报(自然科学版),2025,45(11):1670-1677 ·1677 ·
alleviates sleep deprivation ⁃ induced elevation of Aβ via PPARγ activation and cholesterol reduction[J]. Eur
through regulating neprilysin and AQP4 via the calcineu⁃ J Pharmacol,2021,893:173835
rin/NFAT pathway[J]. Prog Neurobiol,2025,248:102744 [47] CHEN X F,LI S S,BAI Y J,et al. Design and synthesis
[37]MACVICAR B A,NEWMAN E A. Astrocyte regulation of of ligustrazine derivatives as potential anti⁃Alzheimer’s
blood flow in the brain[J]. Cold Spring Harb Perspect agents[J]. Nat Prod Res,2024,38(16):2825-2835
Biol,2015,7(5):a020388 [48] CASTILLO C,BRAVO⁃ARREPOL G,WENDT A,et al.
[38]CHAUHAN N,PALIWAL S,JAIN S,et al. GSK⁃3β and Neuroprotective properties of eudesmin on a cellular model
its inhibitors in Alzheimer’s disease:a recent update[J]. of amyloid⁃β peptide toxicity[J]. J Alzheimers Dis,2023,
Mini Rev Med Chem,2022,22(22):2881-2895 94(s1):S97-S108
[39] WU Q,LI X,JIANG X W,et al. Yuan⁃Zhi decoction in [49]CHOWDHURY D,ROY A K,REDDY V R,et al. Multi⁃
the treatment of Alzheimer ’s disease:an integrated center,open ⁃ label,prospective study shows safety and
approach based on chemical profiling,network pharmaco⁃ therapeutic benefits of a defined Ginkgo biloba extract for
logy,molecular docking and experimental evaluation[J]. adults with major neurocognitive disorder[J]. Dement
Front Pharmacol,2022,13:893244 Geriatr Cogn Disord,2024,53(6):299-309
[40]ZHAO Y J,HE C H,HU S Z,et al. Anti⁃oxidative stress [50] MORATÓ X,MARQUIÉ M,TARTARI J P,et al. A
and cognitive improvement of a semi⁃synthetic isoorientin⁃ randomized,open ⁃ label clinical trial in mild cognitive
based GSK ⁃ 3β inhibitor in rat pheochromocytoma cell impairment with EGb 761 examining blood markers of
PC12 and scopolamine⁃induced AD model mice via AKT/ inflammation and oxidative stress[J]. Sci Rep,2023,13
GSK ⁃ 3β/Nrf2 pathway[J]. Exp Neurol,2024,380: (1):5406
114881 [51]YANG S Q,FAN D H,SU S X,et al. Effects of pressing
[41]CHEN Y X,SU Y,RUN X Q,et al. Pretreatment of PC12 moxibustion at Baihui(GV 20)and Guanyuan(CV 4)on
cells with 17β⁃estradiol prevents Aβ⁃induced down⁃regu⁃ cognitive impairment and serum levels of Aβ1⁃42,tau,
lation of CREB phosphorylation and prolongs inhibition of p ⁃ tau in patients with mild to moderate Alzheimer’s
GSK⁃3β[J]. J Mol Neurosci,2013,50(3):394-401 disease[J]. Zhongguo Zhen Jiu,2024,44(3):255-260
[42] YANG S S,SHI H Y,ZENG P,et al. Bushen⁃Huatan⁃ [52] YNAG J Y,JIANG J,TIAN H L,et al. Effect of elec⁃
Yizhi formula reduces spatial learning and memory chal⁃ troacupuncture on learning ⁃ memory ability and expres⁃
lenges through inhibition of the GSK⁃3β/CREB pathway sion of IL ⁃ 1β,IL ⁃ 6 and TNF ⁃ α in hippocampus and
in AD ⁃ like model rats[J]. Phytomedicine,2021,90: spleen in mice with Alzheimer’s disease[J]. Acupunct
153624 Res,2021,46(5):353-361
[43]ZHANG K X,ZHANG J W,JIANG Y H,et al. Danggui⁃ [53]HUANG R,GONG X,NI J Z,et al. Effect of acupuncture
Shaoyao ⁃ San can ameliorate Alzheimer ’s disease by plus medication on expression of Bcl⁃2 and Bax in hippo⁃
inhibiting hippocampal neuron apoptosis:findings from campus in rats with Alzheimer’s disease[J]. Chin Acu⁃
serum pharmacology[J]. Drug Des Devel Ther,2025,19: punct Moxibustion,2019,39(4):397-402
911-929 [54]程美佳,袁常斌,鞠业涛,等. 涤痰汤通过调节IKB/NF⁃
[44]LIAO Y F,LAI Y Y,XU H L,et al. Bushen⁃Yizhi formula κB通路和细胞凋亡抑制阿尔茨海默病小鼠Tau蛋白过
ameliorates mitochondrial dysfunction and oxidative 度磷酸化[J]. 时珍国医国药,2024,35(2):270-274
stress via AMPK/Sirt1 signaling pathway in D⁃gal⁃ CHENG M J,YUAN C B,JU Y T,et al. Ditan Decoction
induced aging rats[J]. Chin Med,2023,18(1):53 inhibits Tau protein hyperphosphorylation in mice with
[45]蒋 苏,李进冬. 探讨中药复方华佗再造丸治疗阿尔茨 Alzheimer’s disease by regulating IKB/NF ⁃ κB pathway
海默病老年患者认知功能障碍的临床疗效[J]. 内蒙古 and apoptosis[J]. Lishizhen Med Mater Med Res,2024,
中医药,2024,43(12):3-4 35(2):270-274
JIANG S,LI J D. The clinical effect of Chinese herbal [55]CHIU Y J,LIN C H,LEE M C,et al. Formulated Chinese
compound Huatuo Zizao Pill on cognitive dysfunction in medicine Shaoyao Gancao Tang reduces NLRP1 and
elderly patients with Alzheimer’s disease[J]. Inner NLRP3 in Alzheimer’s disease cell and mouse models for
Mongolia Traditional Chinese Medicine,2024,43(12): neuroprotection and cognitive improvement[J]. Aging
3-4 (Albany NY),2021,13(11):15620-15637
[46] KE C H,PENG Y,YUAN Z Q,et al. Ginsenoside Rb1 [收稿日期] 2025-03-14
protected PC12 cells from Aβ25⁃35⁃induced cytotoxicity (本文编辑:蒋 莉)

