Page 31 - 南京医科大学自然版
P. 31
第45卷第11期 林书慧,钱萌森,朱 静,等. METTL3介导的KIF11 mRNA m6A修饰通过PI3K/AKT信号通路促进结
2025年11月 直肠癌进展[J]. 南京医科大学学报(自然科学版),2025,45(11):1546-1562 ·1561 ·
526 colorectal cancer proliferation and metastasis by activat⁃
[6] CHEN D L,WANG J H,LI Y,et al. LncRNA NEAT1 sup⁃ ing STAT3[J]. J Transl Med,2023,21(1):418
presses cellular senescence in hepatocellular carcinoma [19]LIU W J,ZHANG Z L,LUO X T,et al. m6A⁃mediated
via KIF11 ⁃ dependent repression of CDKN2A[J]. Clin LINC02038 inhibits colorectal cancer progression via reg⁃
Transl Med,2023,13(9):e1418 ulation of the FAM172A/PI3K/AKT pathway via competi⁃
[7] ZUIDHOF H R,MÜLLER C,KORTMAN G,et al. The tive binding with miR⁃552⁃5p[J]. Int J Oncol,2023,63
m6A demethylase FTO promotes C/EBPβ⁃LIP translation (1):81
to perform oncogenic functions in breast cancer cells[J]. [20]BAKR M,ABD ⁃ ELMAWLA M A,ELIMAM H,et al.
FEBS J,2025,292(10):2688-2709 Telomerase RNA component lncRNA as potential diag⁃
[8] ZHU Z M,HUO F C,SHI C,et al. METTL3 ⁃ mediated nostic biomarker promotes CRC cellular migration and
m6A modification of PAK6 drives cervical cancer progres⁃ apoptosis evasion via modulation of β⁃catenin protein lev⁃
sion through activating MAPK14[J]. Int J Biol Macromol, el[J]. Noncoding RNA Res,2023,8(3):302-314
2025,309:142880 [21]BIAN Y B,WANG Y,XU S F,et al. m6A modification of
[9] ZOU J,SHI X,WU Z,ZUO S,et al. MRTX1133 attenu⁃ long non⁃coding RNA HNF1A⁃AS1 facilitates cell cycle
ates KRAS(G12D)mutated⁃colorectal cancer progression progression in colorectal cancer via IGF2BP2 ⁃ mediated
through activating ferroptosis activity via METTL14/ CCND1 mRNA stabilization[J]. Cells,2022,11(19):
LINC02159/FOXC2 axis[J]. Transl Oncol,2025,52: 3008
102235 [22]ZENG H,HOU Y X,ZHOU X Y,et al. Cancer⁃associated
[10]ZHOU D,TANG W W,XU Y D,et al. METTL3/YTHDF2 fibroblasts facilitate premetastatic niche formation
m6A axis accelerates colorectal carcinogenesis through through lncRNA SNHG5⁃mediated angiogenesis and vas⁃
epigenetically suppressing YPEL5[J]. Mol Oncol,2021, cular permeability in breast cancer[J]. Theranostics,
15(8):2172-2184 2022,12(17):7351-7370
[11]ZHAO S,SONG P,ZHOU G,et al. METTL3 promotes the [23]MU H Y,CHEN J Z,HUANG W J,et al. OmicShare tools:
malignancy of non⁃small cell lung cancer by N6⁃methyl⁃ a zero⁃code interactive online platform for biological data
adenosine modifying SFRP2[J]. Cancer Gene Ther, analysis and visualization[J]. Imeta,2024,3(5):e228
2023,30(8):1094-1104 [24]ZHU T Y,HONG L L,LING Z Q. Oncofetal protein
[12]XUE L,LI J,LIN Y H,et al. m6A transferase METTL3⁃in⁃ IGF2BPs in human cancer:functions,mechanisms and
duced lncRNA ABHD11⁃AS1 promotes the Warburg ef⁃ therapeutic potential[J]. Biomark Res,2023,11(1):62
fect of non ⁃ small ⁃ cell lung cancer[J]. J Cell Physiol, [25]WEI Y Y,JIANG Y Z,ZOU F,et al. Activation of PI3K/
2021,236(4):2649-2658 Akt pathway by CD133⁃p85 interaction promotes tumori⁃
[13]WANG J Y,CHEN L J,QIANG P. The role of IGF 2BP2, genic capacity of glioma stem cells[J]. Proc Natl Acad
an m6A reader gene,in human metabolic diseases and Sci USA,2013,110(17):6829-6834
cancers[J]. Cancer Cell Int,2021,21(1):99 [26]ZHU Y L,YU J W,WANG S L,et al. Overexpression of
[14]WANG J Y,ZHU M X,ZHU J H,et al. HES1 promotes CD133 enhances chemoresistance to 5⁃fluorouracil by ac⁃
aerobic glycolysis and cancer progression of colorectal tivating the PI3K/Akt/p70S6K pathway in gastric cancer
cancer via IGF2BP2⁃mediated GLUT1 m6A modification[J]. cells[J]. Oncol Rep,2014,32(6):2437-2444
Cell Death Discov,2023,9(1):411 [27]ZHU M,YU R,LIU Y,et al. LncRNA H19 participates in
[15]HU X G,PENG W X,ZHOU H X,et al. IGF2BP2 regu⁃ leukemia inhibitory factor mediated stemness promotion
lates DANCR by serving as an N6 ⁃ methyladenosine in colorectal cancer cells[J]. Biochem Genet,2024,62
reader[J]. Cell Death Differ,2020,27(6):1782⁃1794 (5):3695-3708
[16]BARZEGAR BEHROOZ A,SYAHIR A,AHMAD S. [28]DIEFENBACH R J,MACKAY J P,ARMATI P J,et al.
CD133:beyond a cancer stem cell biomarker[J]. J Drug The C⁃terminal region of the stalk domain of ubiquitous
Target,2019,27(3):257-269 human kinesin heavy chain contains the binding site for
[17]ZHU Y L,KONG F F,ZHANG C H,et al. CD133 medi⁃ kinesin light chain[J]. Biochemistry,1998,37(47):
ates the TGF ⁃ β1 ⁃ induced activation of the PI3K/ERK/ 16663-16670
P70S6K signaling pathway in gastric cancer cells[J]. On⁃ [29]LUCANUS A J,YIP G W. Kinesin superfamily:roles in
col Lett,2017,14(6):7211-7216 breast cancer,patient prognosis and therapeutics[J]. On⁃
[18]SHI Q,HE Y,HE S Y,et al. RP11⁃296E3.2 acts as an im⁃ cogene,2018,37(7):833-838
portant molecular chaperone for YBX1 and promotes [30]SHARP D J,ROGERS G C,SCHOLEY J M. Microtubule

