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The authors declare no conflict of interests． adrenal and hypothalamic ⁃ pituitary ⁃ gonadal axes：sex
作者贡献声明： differences in regulation of stress responsivity［J］. Stress，
吴涛负责论文撰写与修改；行浩然负责筛选文献及论文 2017，20（5）：476-494
修改；鲍天昊负责指导论文框架设计、审查文章内容。 ［11］HIRTZ R，LIBUDA L，HINNEY A，et al. Lack of evidence
Author’s Contributions： for a relationship between the hypothalamus⁃pituitary⁃
WU Tao drafted and revised the manuscript；XING Haoran adrenal and the hypothalamus ⁃ pituitary ⁃ thyroid axis in
screened the literature and contributed to manuscript revision； adolescent depression［J］. Front Endocrinol（Lausanne），

BAO Tianhao provided guidance on the overall framework de⁃ 2021，12：662243
sign and reviewed the content of the manuscript. ［12］ZAJKOWSKA Z，NIKKHESLAT N，MANFRO P H，et al.
［参考文献］ Sex⁃specific inflammatory markers of risk and presence of
depression in adolescents［J］. J Affect Disord，2023，342：
［1］ SHU Y N，AO N，WEN X，et al. The p factor outweighs
69-75
the specific internalizing factor in predicting recurrences
［13］ZONCA V，MARIZZONI M，SALERI S，et al. Inflamma⁃
of adolescent depression［J］. Eur Psychiatry，2024，67
tion and immune system pathways as biological signatures
（1）：e28
of adolescent depression ⁃ the IDEA ⁃ RiSCo study［J］.
［2］ LANG A N，ZHONG Y，LEI W K，et al. Neural mecha⁃
Transl Psychiatry，2024，14（1）：230
nism of non ⁃ adaptive cognitive emotion regulation in
［14］ SCHWARTZ J J，ROSKE C，LIU Q，et al. C⁃reactive
patients with non⁃suicidal self⁃injury［J］. Compr Psychiatry，
protein does not predict future depression onset in adoles⁃
2024，133：152487
cents：preliminary findings from a longitudinal study［J］.
［3］ HU J，PENG C，XU Z X，et al. Childhood maltreatment
J Child Adolesc Psychopharmacol，2024，34（5）：233-240
and its dose⁃response relation with non⁃suicidal self⁃injury
［15］D’ACUNTO G，NAGEYE F，ZHANG J H，et al. Inflam⁃
among adolescents：the mediating role of mobile phone
matory cytokines in children and adolescents with depres⁃
addiction［J］. Public Health，2025，239：48-54
sive disorders：a systematic review and meta⁃analysis［J］.
［4］ LAI W J，WU H R，YANG L W，et al. Prevalence of
J Child Adolesc Psychopharmacol，2019，29（5）：362-369
unhealthy behaviors and their associations with non ⁃
［16］YANG S R，HAN J J，YE Z H，et al. The correlation of
suicidal self⁃injury，suicidal ideation and suicide attempt
inflammation，tryptophan⁃kynurenine pathway，and suicide
among Chinese adolescents［J］. Child Adolesc Psychiatry risk in adolescent depression［J］. Eur Child Adolesc
Ment Health，2024，18（1）：61
Psychiatry，2025，34（5）：1557-1567
［5］ YANG H T，CHEN Y，TAO Q Y，et al. Integrative molecular ［17］VAN DIJK M T，MURPHY E，POSNER J E，et al. Associ⁃
and structural neuroimaging analyses of the interaction
ation of multigenerational family history of depression
between depression and age of onset：a multimodal magnetic with lifetime depressive and other psychiatric disorders in
resonance imaging study［J］. Prog Neuro Psychopharmacol children：results from the adolescent brain cognitive
Biol Psychiatry，2024，134：111052 development（ABCD）study［J］. JAMA Psychiatry，2021，
［6］ GUO Y，LU R X，OU Y W，et al. A study on the association 78（7）：778-787
between prefrontal functional connectivity and non⁃suicidal ［18］ZHAO B，FAN Q Y，LIU J T，et al. Identification of key
self⁃injury in adolescents with depression［J］.Front Neurol， modules and genes associated with major depressive
2024，15：1382136 disorder in adolescents［J］. Genes（Basel），2022，13（3）：
［7］ ZHENG R P，BU C X，CHEN Y，et al. Decreased intrinsic 464
neural timescale in treatment ⁃ naïve adolescent depres⁃ ［19］CHIANG J J，COLE S W，BOWER J E，et al. Depressive
sion［J］. J Affect Disord，2024，348：389-397 symptoms and immune transcriptional profiles in late
［8］ MURRAY L，JAFFE N M，TIERNEY A O，et al. Brain adolescents［J］. Brain Behav Immun，2019，80：163-169
mechanisms of rumination and negative self ⁃ referential ［20］CIUCULETE D M，VOISIN S，KULAR L，et al. meQTL
processing in adolescent depression［J］. J Affect Disord， and ncRNA functional analyses of 102 GWAS ⁃ SNPs
2024，366：83-90 associated with depression implicate HACE1 and SHANK2
［9］ ZWOLINSKA W，DMITRZAK⁃WEGLARZ M，SŁOPIEN genes［J］. Clin Epigenetics，2020，12（1）：99
A. Biomarkers in child and adolescent depression［J］. ［21］SICHKO S，BUI T Q，VINOGRAD M，et al. Psychobiology
Child Psychiatry Hum Dev，2023，54（1）：266-281 of stress and adolescent depression（PSY SAD）study：
［10］ OYOLA M G ，HANDA R J. Hypothalamic⁃pituitary⁃ protocol overview for an fMRI⁃based multi⁃method investi⁃