Page 78 - 南京医科大学自然版
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第45卷第12期
·1760 · 南 京 医 科 大 学 学 报 2025年12月
A B
MR Test
Inverse variance weighted Weighted median
MR Egger Weighted mode
Simple mode
0.10 0.05
SNP effect on acute pancreatitis 0.05 SNP effect on acute pancreatitis 0.00
0.00
-0.05
-0.05
0.015 0.020 0.025 0.030 0.015 0.020 0.025 0.030
SNP effect on αKG SNP effect on αKG
C 0.10 D
SNP effect on acute pancreatitis -0.05 SNP effect on acute pancreatitis -0.05
0.05
0.00
0.00
0.03 0.06 0.09 0.03 0.06 0.09
SNP effect on indolepropionate SNP effect on indolepropionate
E
Study log2OR SE（log2OR） Odds ratio OR 95%CI Weight
0
Exposure=alpha⁃ketoglutarate 0 0 0 0
ebi⁃a⁃GCST90018789 1.017 3 0.415 8 2.77 1.22-6.25 55.5%
finn⁃b⁃K11_ACUTPANC 1.072 2 0.464 2 2.92 1.18-7.26 44.5%
2 2
Heterogeneity：I =0%，t =0，P=0.93
Common effect model 2.83 1.54-5.20 100.0%
0.2 0.5 1.0 2.0 5.0
F
Study log2OR SE（log2OR） Odds ratio OR 95%CI Weight
0
Exposure=alpha⁃ketoglutarate 0 0 0 0
ebi⁃a⁃GCST90018789 -2.562 4 0.193 7 0.57 0.39-0.83 64.3%
finn⁃b⁃K11_ACUTPANC -0.725 1 0.259 6 0.48 0.29-0.81 35.7%
2
2
Heterogeneity：I =0%，t =0，P=0.62
Common effect model 0.54 0.40-0.73 100.0%
0.5 1.0 2.0
A：Analysis of the relationship between serum αKG and the incidence of AP based on the ebi⁃a⁃GCST90018789 dataset，with different lines repre⁃
senting various statistical methods. B：Analysis of the relationship between serum αKG and the incidence of AP based on the finnb⁃K11_ACUTPANC
dataset. C：Analysis of the relationship between serum INDO and the incidence of AP based on the ebi⁃a⁃GCST90018789 dataset. D：Analysis of the rela⁃
tionship between serum INDO and the incidence of AP based on the finnb⁃K11_ACUTPANC dataset. E：Two rounds Meta⁃analysis of the relationship
between αKG and the incidence of AP based on the ebi⁃a⁃GCST90018789 and finnb⁃K11_ACUTPANC datasets. F：Two rounds Meta⁃analysis of the re⁃
lationship between INDO and the incidence of AP based on the ebi⁃a⁃GCST90018789 and finnb⁃K11_ACUTPANC datasets.
图1 αKG、INDO与AP发病因果关系分析图
Figure 1 Causal relationship analysis of αKG and INDO with the onset of AP
