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第45卷第2期                      陆瑄贝,王晓东. 甲状腺激素与心脏纤维化研究进展[J].
                  2025年2月                     南京医科大学学报(自然科学版),2025,45(2):278-284                        ·283 ·


                    myocardial disease[J]. Nat Rev Cardiol,2022,19(7):  ol,2020,11:529075
                    435-455                                      [34]LI Y Y,FENG Y Q,KADOKAMI T,et al. Myocardial ex⁃
               [21]LIU C,LIM S T,TEO M H Y,et al. Collaborative regula⁃  tracellular matrix remodeling in transgenic mice overex⁃
                    tion of LRG1 by TGF⁃β1 and PPAR⁃β/δ modulates chron⁃  pressing tumor necrosis factor alpha can be modulated by
                    ic pressure overload ⁃ induced cardiac fibrosis[J]. Circ  anti ⁃ tumor necrosis factor alpha therapy[J]. Proc Natl
                    Heart Fail,2019,12(12):e005962                     Acad Sci U S A,2000,97(23):12746-12751
               [22]PENG D,FU M,WANG M,et al. Targeting TGF⁃β signal  [35]DÍEZ J J,HERNANZ A,MEDINA S,et al. Serum concen⁃
                    transduction for fibrosis and cancer therapy[J]. Mol Can⁃  trations of tumour necrosis factor⁃alpha(TNF⁃alpha)and
                    cer,2022,21(1):104                                 soluble TNF⁃alpha receptor p55 in patients with hypothy⁃
               [23]ALONSO ⁃ MERINO E,MARTÍN OROZCO R,RUÍZ ⁃            roidism and hyperthyroidism before and after normaliza⁃
                    LLORENTE L,et al. Thyroid hormones inhibit TGF⁃β sig⁃  tion of thyroid function[J]. Clin Endocrinol(Oxf),2002,
                    naling and attenuate fibrotic responses[J]. Proc Natl  57(4):515-521
                    Acad Sci U S A,2016,113(24):E3451-E3460      [36]MARCHIORI R C,PEREIRA L A F,NAUJORKS A A,et
               [24]ANTAR S A,ASHOUR N A,MARAWAN M E,et al. Fi⁃         al. Improvement of blood inflammatory marker levels in
                    brosis:types,effects,markers,mechanisms for disease  patients with hypothyroidism under levothyroxine treat⁃
                    progression,and its relation with oxidative stress,immuni⁃  ment[J]. BMC Endocr Disord,2015,15:32
                    ty,and inflammation[J]. Int J Mol Sci,2023,24(4):4004  [37]KUZMAN J A,O'CONNELL T D,GERDES A M. Rapa⁃
               [25]DIMAURO I,PARONETTO M P,CAPOROSSI D. Exer⁃          mycin prevents thyroid hormone⁃induced cardiac hyper⁃
                    cise,redox homeostasis and the epigenetic landscape[J].  trophy[J]. Endocrinology,2007,148(7):3477-3484
                    Redox Biol,2020,35:101477                    [38]KERP H,HÖNES G S,TOLSTIK E,et al. Protective ef⁃
               [26]VAN DER POL A,VAN GILST W H,VOORS A A,et al.        fects of thyroid hormone deprivation on progression of
                    Treating oxidative stress in heart failure:past,present  maladaptive cardiac hypertrophy and heart failure[J].
                    and future[J]. Eur J Heart Fail,2019,21(4):425-435  Front Cardiovasc Med,2021,8:683522
               [27]MARTINS D,GARCIA L R,QUEIROZ D A R,et al. Oxi⁃  [39]PINGITORE A,IERVASI G,FORINI F. Role of the thy⁃
                    dative stress as a therapeutic target of cardiac remodel⁃  roid system in the dynamic complex network of cardiopro⁃
                    ing[J]. Antioxidants(Basel),2022,11(12):2371       tection[J]. Eur Cardiol,2016,11(1):36-42
               [28]HUANG X,LIN X,WANG L,et al. Substitution of   [40]LARSSON S C,MICHAËLSSON K,BURGESS S. IGF⁃1
                    SERCA2 Cys674 aggravates cardiac fibrosis by promot⁃  and cardiometabolic diseases:a Mendelian randomisation
                    ing the transformation of cardiac fibroblasts to cardiac  study[J]. Diabetologia,2020,63(9):1775-1782
                    myofibroblasts[J]. Biochem Pharmacol,2022,203:  [41]YANG Q,HUANG D D,LI D G,et al. Tetramethylpyr⁃
                    115164                                             azine exerts a protective effect against injury from acute
               [29]ERDAMAR H,DEMIRCI H,YAMAN H,et al. The effect       myocardial ischemia by regulating the PI3K/Akt/GSK⁃3β
                    of hypothyroidism,hyperthyroidism,and their treatment  signaling pathway[J]. Cell Mol Biol Lett,2019,24:17
                    on parameters of oxidative stress and antioxidant status[J].  [42]WANG Y,ZHANG S. Expression and regulation by thy⁃
                    Clin Chem Lab Med,2008,46(7):1004-1010             roid hormone(TH)of zebrafish IGF⁃I gene and amphiox⁃
               [30]PAN T,ZHONG M,ZHONG X,et al. Levothyroxine re⁃      us IGFl gene with implication of the origin of TH/IGF sig⁃
                    placement therapy with vitamin E supplementation pre⁃  naling pathway[J]. Comp Biochem Physiol A Mol Integr
                    vents oxidative stress and cognitive deficit in experimen⁃  Physiol,2011,160(4):474-479
                    tal hypothyroidism[J]. Endocrine,2013,43(2):434-  [43]XING W,GOVONI K E,DONAHUE L R,et al. Genetic
                    439                                                evidence that thyroid hormone is indispensable for prepu⁃
               [31]HANNA A,FRANGOGIANNIS N G. Inflammatory cyto⁃       bertal insulin⁃like growth factor⁃I expression and bone ac⁃
                    kines and chemokines as therapeutic targets in heart fail⁃  quisition in mice[J]. J Bone Miner Res,2012,27(5):
                    ure[J]. Cardiovasc Drugs Ther,2020,34(6):849-863   1067-1079
               [32]LIU M,LÓPEZ DE JUAN ABAD B,CHENG K. Cardiac   [44]SCHÜTTE J P,MANKE M⁃C,HEMMEN K,et al. Platelet
                    fibrosis:myofibroblast ⁃ mediated pathological regulation  ⁃derived micrornas regulate cardiac remodeling after myo⁃
                    and drug delivery strategies[J]. Adv Drug Deliv Rev,  cardial ischemia[J]. Circ Res,2023,132(7):e96-e113
                    2021,173:504-519                             [45]LIU M N,LUO G,GAO W J,et al. miR⁃29 family:a po⁃
               [33]THOMAS T P,GRISANTI L A. The dynamic interplay be⁃  tential therapeutic target for cardiovascular disease[J].
                    tween cardiac inflammation and fibrosis[J]. Front Physi⁃  Pharmacol Res,2021,166:105510
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