Page 145 - 南京医科大学自然版

第45卷第3期 韩经略，安方梅. 成纤维细胞在胃黏膜癌变及胃癌药物治疗中的研究进展［J］.
2025年3月 南京医科大学学报（自然科学版），2025，45（3）：426-434 ·433 ·

sion［J］. Nat Cell Biol，2017，19（3）：224-237 ［34］ YANG X G，LIN Y L，SHI Y H，et al. FAP promotes im⁃
［22］ROJAS A，ARAYA P，GONZALEZ I，et al. Gastric tumor munosuppression by cancer⁃associated fibroblasts in the
microenvironment［J］. Adv Exp Med Biol，2020，1226： tumor microenvironment via STAT3⁃CCL2 signaling［J］.
23-35 Cancer Res，2016，76（14）：4124-4135
［23］WU C Q，LI D M，CHENG X，et al. Downregulation of can⁃ ［35］ BOURHIS M，PALLE J，GALY⁃FAUROUX I ，et al.
cer⁃associated fibroblast exosome⁃derived miR⁃29b⁃1⁃5p Direct and indirect modulation of T cells by VEGF ⁃ A
restrains vasculogenic mimicry and apoptosis while accel⁃ counteracted by anti⁃angiogenic treatment［J］. Front Im⁃
erating migration and invasion of gastric cancer cells via munol，2021，12：616837
immunoglobulin domain⁃containing 1/zonula occluden⁃1 ［36］SONG M J，HE J Y，PAN Q Z，et al. Cancer⁃associated
axis［J］. Cell Cycle，2023，22（17）：1807-1826 fibroblast⁃mediated cellular crosstalk supports hepatocel⁃
［24］XU G F，ZHANG B，YE J H，et al. Exosomal miRNA⁃139 lular carcinoma progression［J］. Hepatology，2021，73
in cancer ⁃ associated fibroblasts inhibits gastric cancer （5）：1717-1735
progression by repressing MMP11 expression［J］. Int J Biol ［37］ELLEM S J，TAYLOR R A，FURIC L，et al. A pro⁃tumou⁃
Sci，2019，15（11）：2320-2329 rigenic loop at the human prostate tumour interface orches⁃
［25］HARPER J，SAINSON R C. Regulation of the anti⁃tumour trated by oestrogen，CXCL12 and mast cell recruitment［J］.
immune response by cancer ⁃ associated fibroblasts［J］. J Pathol，2014，234（1）：86-98
Semin Cancer Biol，2014，25：69-77 ［38］ YANG F C，CHEN S，CLEGG T，et al. Nf1 +/- mast cells
［26］CASSETTA L，POLLARD J W. A timeline of tumour⁃asso⁃ induce neurofibroma like phenotypes through secreted
ciated macrophage biology［J］. Nat Rev Cancer，2023，23 TGF⁃beta signaling［J］. Hum Mol Genet，2006，15（16）：
（4）：238-257 2421-2437
［27］ HERRERA M，HERRERA A，DOMÍNGUEZ G，et al. ［39］ BAE W J，KIM S，AHN J M，et al. Estrogen⁃responsive
Cancer⁃associated fibroblast and M2 macrophage markers cancer⁃associated fibroblasts promote invasive property of
together predict outcome in colorectal cancer patients［J］. gastric cancer in a paracrine manner via CD147 produc⁃
Cancer Sci，2013，104（4）：437-444 tion［J］. FASEB J，2022，36（11）：e22597
［28］PAN Y Y，YU Y D，WANG X J，et al. Tumor⁃associated ［40］ZHANG H Y，DENG T，LIU R，et al. CAF secreted miR⁃
macrophages in tumor immunity［J］. Front Immunol， 522 suppresses ferroptosis and promotes acquired chemo⁃
2020，11：583084 resistance in gastric cancer［J］. Mol Cancer，2020，19
［29］QUANTE M，TU S P，TOMITA H，et al. Bone marrow⁃de⁃ （1）：43
rived myofibroblasts contribute to the mesenchymal stem ［41］ YAO L Z，HOU J Y，WU X Y，et al. Cancer⁃associated
cell niche and promote tumor growth［J］. Cancer Cell， fibroblasts impair the cytotoxic function of NK cells in
2011，19（2）：257-272 gastric cancer by inducing ferroptosis via iron regulation［J］.
［30］ TAN B H，SHI X J，ZHANG J，et al. Inhibition of rspo⁃ Redox Biol，2023，67：102923
Lgr4 facilitates checkpoint blockade therapy by switching ［42］LIN X，KANG K，CHEN P，et al. Regulatory mechanisms
macrophage polarization［J］. Cancer Res，2018，78（17）： of PD⁃1/PD⁃L1 in cancers［J］. Mol Cancer，2024，23（1）：
4929-4942 108
［31］LI D D，XIA L Y，HUANG P，et al. Cancer⁃associated ［43］ MU L S，YU W T，SU H L，et al. Relationship between
fibroblast ⁃ secreted IGFBP7 promotes gastric cancer by the expressions of PD ⁃ L1 and tumour ⁃ associated fibro⁃
enhancing tumor associated macrophage infiltration via blasts in gastric cancer［J］. Artif Cells Nanomed Biotech⁃
FGF2/FGFR1/PI3K/AKT axis［J］. Cell Death Discov， nol，2019，47（1）：1036-1042
2023，9（1）：17 ［44］LI Z Q，ZHOU J W，ZHANG J J，et al. Cancer⁃associated
［32］GORDON S R，MAUTE R L，DULKEN B W，et al. PD⁃1 fibroblasts promote PD ⁃ L1 expression in mice cancer
expression by tumour ⁃ associated macrophages inhibits cells via secreting CXCL5［J］. Int J Cancer，2019，145
phagocytosis and tumour immunity［J］. Nature，2017，545 （7）：1946-1957
（7655）：495-499 ［45］INOUE C，MIKI Y，SAITO R，et al. PD⁃L1 induction by
［33］GOK YAVUZ B，GUNAYDIN G，GEDIK M E，et al. Cancer cancer⁃associated fibroblast⁃derived factors in lung adeno⁃
associated fibroblasts sculpt tumour microenvironment by carcinoma cells［J］. Cancers，2019，11（9）：1257
recruiting monocytes and inducing immunosuppressive ［46］GONG J，LIN Y Y，ZHANG H Q，et al. Reprogramming of
+
PD⁃1 TAMs［J］. Sci Rep，2019，9（1）：3172 lipid metabolism in cancer⁃associated fibroblasts potenti⁃