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A B
AIM2 High Low CHMP4B High Low
** *
0.3 0.3
Fraction 0.2 Fraction 0.2

0.1 0.1
0 0
B cells naive B cells memory Plasma cells T cells CD8 T cells CD4 naive T cells CD4 memory resting memory activated T cells follicular helper （Tregs） T cells regulatory T cells gamma delts NK cells rsting NK cells activated Monocytes Macrophages M0 Macrophages M1 Macrophages M2 Dendritic cells resting Dendritic cells activated Mast cells resting Mast cells activated Eosinophils Neutrophils B cells naive B cells memory Plasma cells T cells CD8 T cel

C T cells CD4 D T cells CD4 T cells CD4
NLRC4 High Low NLRP2 High Low
* * * **
0.3 0.3
Fraction 0.2 Fraction 0.2

0.1 0.1

0 0
B cells naive B cells memory Plasma cells T cells CD8 T cells CD4 naive memory resting memory activated T cells follicular helper （Tregs） T cells gamma delts NK cells rsting NK cells activated Monocytes Macrophages M0 Macrophages M1 Macrophages M2 Dendritic cells resting Dendritic cells activated Mast cells resting Mast cells activated Eosinophils Neutrophils B cells naive B cells memory Plasma cells T cells CD8 T cells CD4 naive memory resting m

T cells CD4 T cells CD4 T cells regulatory T cells CD4 T cells CD4 T cells regulatory

E PYCARD High Low

0.3
Fraction 0.2

0.1
0
B cells naive B cells memory Plasma cells T cells CD8 T cells CD4 naive memory resting memory activated T cells follicular helper （Tregs） T cells gamma delts NK cells rsting NK cells activated Monocytes Macrophages M0 Macrophages M1 Macrophages M2 Dendritic cells resting Dendritic cells activated Mast cells resting Mast cells activated Eosinophils Neutrophils

T cells CD4 T cells CD4 T cells regulatory

A：Correlation analysis between immunocytes and AIM2. B：Correlation analysis between immunocytes and CHMP4B. C：Correlation analysis be⁃
tween immunocytes and NLRC4. D：Correlation analysis between immunocytes and NLRP2. E：Correlation analysis between immunocytes and PY⁃
*
**
CARD. P < 0.05 and P < 0.01.
图7 免疫细胞与特征基因的相关性分析
Figure 7 Correlation analysis between immunocytes and signature genes
活性异常可能与PCOS的发病密切相关 。细胞焦 和机制上与细胞凋亡有差异，与阿尔茨海默病和2型
［19］
亡作为一种新的促炎程序性细胞死亡方式，在形态 糖尿病相关 。然而，细胞焦亡调控PCOS的确切机
［7］