Page 93 - 南京医科大学自然版

第45卷第4期 秦 浩，谢卫国，陈小红，等. 基于16S核糖体RNA高通量测序前瞻性分析50岁及以上重度
2025年4月 烧伤患者早期肠道菌群变化［J］. 南京医科大学学报（自然科学版），2025，45（4）：523-534 ·529 ·

A r=0.060，P=0.015 B r=0.146，P=0.019
0.6 300
Group
Burn
Control 250
0.3 （Bray⁃Curtis） 200
［10.2%］ 0 150

PCoA2 100

-0.3 Rank of distance 50

-0.6 0
-0.3 0 0.3 0.6 Between Burn Control
PCoA1［10.7%］

A：Represents the principal coordinate analysis（PCoA）of beta diversity，where PCoA1 reflects the differences between the two groups with a
contribution rate of 10.70%，and PCoA2 reflects the differences with a contribution rate of 10.20%. B：Weighted Bray⁃Curtis clustering distance matrix
for the two samples. Between：the inter⁃group differences between the two sample groups.
图5 Beta多样性分析
Figure 5 Beta diversity analysis

A Control Burn B
c_ Bacilli
f_Enterococcaceae
g_Enterococcus
g_Staphylococcus
f_Staphylococcaceae
o_Staphylococcales
p_Verrucomicrobiota
c_Verrucomicrobiae
o_Verrucomicrobiales
f_Akkermansiaceae
g_Akkermansia
f_Lactobacillaceae
g_Lactobacillus
o_Clostridia_UCG⁃014
g_Clostridium innocuum _group
o_Clostridic_vadinBB60_group Burn
o_Micrococcales Control
g_Rothia
f_Micrococcaceae ab p_Verrucomicrobiota au：g_Prevotella
g_Clostridioides ac c_Bacilli av：g_Staphylococcus
o_Actinomycetales ad c_Clostridia aw：g_Akkermansia
f_Actinomycetaceae ae c_Verrucomicrobiae ax：g_Lactobacillus
g_Catenibacterium af c_Staphylococcales ay：g_Blautia
g_Actinomyces ag o_Verrucomicrobiales az：g_Agathobacter
g_Olsenella ah o_Clostridia_UCG_014 bc：g_Anaerostipes
g_ Lachnospiraceae_UCG⁃004 aio_Clostridic_vadinBB60_group bd：g_Clostridiuminnocuum_group
g_ Tyzzerella aj o_Micrococcales be：g_Holdemanella
g_Fusicatenibacter ak o_Actinomycetales bf：g_Rothia
g_Romboutsia al o_Enterococcaceae bg：g_Romboutsia
g_Holdemanella am o_Prevotellaceae bh：g_Fusicatenibacter
g_Anaerostipes an o_Staphylococcaceae bi：g_ Tyzzerella
g_Agathobacter ao o_Akkermansiaceae bj：g_Clostridioides
g_Blautia ap o_Lactobacillaceae bk：g_Lachnospiraceae_UCG_004
g_Prevotella aq o_Micrococcaceae bl：g_Catenibacterium
f_Prevotellaceae ar o_Actinomycetaceae bm：g_Actinomyces
g_Faecalibacterium as o_Faecalibacterium bn：g_Olsenella
c_Clostridia at g_Enterococcus
-5 -4 -3 -2 -1 0 1 2 3 4 5
LDA score
A：Bar chart illustrating the microbial distribution between the burn group and the control group. The colors of the bars indicate the different
groups，while the lengths of the bars reflect the LDA scores，representing the magnitude of significant differences in species between the groups. B：Phy⁃
logenetic tree depicting the microbial distribution between the burn group and the control group. The concentric circles represent different taxonomic
levels from phylum to genus，with each small circle at a given level representing a specific classification. The diameter of each small circle corresponds
to its relative abundance at that classification level.
图6 两组差异菌LEfSe分析
Figure 6 LEfSe analysis of differential microbiota between the two groups