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第45卷第5期 陈 微，吴海银，朱东亚. 中性粒细胞：卒中再灌注治疗的绊脚石［J］.
2025年5月 南京医科大学学报（自然科学版），2025，45（5）：593-604 ·603 ·

Cereb Blood Flow Metab，2023，43（3）：393-403 ［58］LI J，KUMARI T，BARAZIA A，et al. Neutrophil DREAM
［46］LIN L，HU K B. Tissue plasminogen activator and inflam⁃ promotes neutrophil recruitment in vascular inflamma⁃
mation：from phenotype to signaling mechanisms［J］. Am tion［J］. J Exp Med，2022，219（1）：e20211083
J Clin Exp Immunol，2014，3（1）：30-36 ［59］CIACCIARELLI A，TESSITORE A，FIUME G，et al. Fac⁃
［47］SHI K B，ZOU M，JIA D M，et al. tPA mobilizes immune tors associated with hemorrhagic transformation after
cells that exacerbate hemorrhagic transformation in endovascular treatment despite early recanalization［J］. J
stroke［J］. Circ Res，2021，128（1）：62-75 Neurol Sci，2023，453：120778
［48］LIBERALE L，BERTOLOTTO M，MINETTI S，et al. Re⁃ ［60］STOLL G，SCHUHMANN M K，NIESWANDT B，et al. An
combinant tissue plasminogen activator（r⁃tPA）induces in intravascular perspective on hyper ⁃ acute neutrophil，T ⁃
vitro human neutrophil migration via low density lipopro⁃ cell and platelet responses：similarities between human
tein receptor⁃related protein 1（LRP⁃1）［J］. Int J Mol Sci， and experimental stroke［J］. J Cereb Blood Flow Metab，
2020，21（19）：7014 2022，42（9）：1561-1567
［49］CUADRADO E，ORTEGA L，HERNÁNDEZ ⁃ GUILLA⁃ ［61］LIN L，BA Z J，TIAN H，et al. Ultrasound⁃responsive ther⁃
MON M，et al. Tissue plasminogen activator（t⁃PA）pro⁃ anostic platform for the timely monitoring and efficient
motes neutrophil degranulation and MMP⁃9 release［J］. J thrombolysis in thrombi of tPA resistance［J］. Nat Com⁃
Leukoc Biol，2008，84（1）：207-214 mun，2024，15（1）：6610
［50］CARBONE F，VUILLEUMIER N，BERTOLOTTO M，et ［62］MENGOZZI L，BARISON I，MALY M，et al. Neutrophil
al. Treatment with recombinant tissue plasminogen activa⁃ extracellular traps and thrombolysis resistance：new in⁃
tor（r⁃TPA）induces neutrophil degranulation in vitro via sights for targeting therapies［J］. Stroke，2024，55（4）：
defined pathways［J］. Vascul Pharmacol，2015，64：16-27 963-971
［51］SHI J，PENG H，YOU S，et al. Increase in neutrophils ［63］VARJÚ I，LONGSTAFF C，SZABÓ L，et al. DNA，his⁃
after recombinant tissue plasminogen activator thromboly⁃ tones and neutrophil extracellular traps exert anti⁃fibrino⁃
sis predicts poor functional outcome of ischaemic stroke： lytic effects in a plasma environment［J］. Thromb Hae⁃
a longitudinal study［J］. Eur J Neurol，2018，25（4）：687- most，2015，113（6）：1289-1298
692 ［64］DUCROUX C，DI MEGLIO L，LOYAU S，et al. Thrombus
［52］TURNER R J，SHARP F R. Implications of MMP9 for neutrophil extracellular traps content impair tPA⁃induced
blood brain barrier disruption and hemorrhagic transfor⁃ thrombolysis in acute ischemic stroke［J］. Stroke，2018，
mation following ischemic stroke［J］. Front Cell Neurosci， 49（3）：754-757
2016，10：56 ［65］LARIDAN E，DENORME F，DESENDER L，et al. Neutro⁃
［53］YAO Y，LIU F，GU Z W，et al. Emerging diagnostic phil extracellular traps in ischemic stroke thrombi［J］.
markers and therapeutic targets in post⁃stroke hemorrhagic Ann Neurol，2017，82（2）：223-232
transformation and brain edema［J］. Front Mol Neurosci， ［66］ZHOU P，LI T，JIN J Q，et al. Interactions between neutro⁃
2023，16：1286351 phil extracellular traps and activated platelets enhance
［54］HUANG J A，WU Y H，CHEN P L，et al. MMP⁃9 upregu⁃ procoagulant activity in acute stroke patients with ICA oc⁃
lation may predict hemorrhagic transformation after endo⁃ clusion［J］. EBioMedicine，2020，53：102671
vascular thrombectomy［J］. Front Neurol，2024，15： ［67］ZHANG S Q，CAO Y Z，DU J W，et al. Neutrophil extra⁃
1400270 cellular traps contribute to tissue plasminogen activator
［55］WANG R R，ZHU Y B，LIU Z W，et al. Neutrophil extra⁃ resistance in acute ischemic stroke［J］. FASEB J，2021，
cellular traps promote tPA⁃induced brain hemorrhage via 35（9）：e21835
cGAS in mice with stroke［J］. Blood，2021，138（1）：91-103 ［68］DESILLES J P，DI MEGLIO L，DELVOYE F，et al. Com⁃
［56］CHEN H S，CHEN X，LUO Y H，et al. Potential molecu⁃ position and organization of acute ischemic stroke throm⁃
lar targets of peroxynitrite in mediating blood⁃brain barrier bus：a wealth of information for future thrombolytic strate⁃
damage and haemorrhagic transformation in acute ischae⁃ gies［J］. Front Neurol，2022，13：870331
mic stroke with delayed tissue plasminogen activator treat⁃ ［69］KLONER R A，KING K S，HARRINGTON M G. No⁃re⁃
ment［J］. Free Radic Res，2018，52（11/12）：1220-1239 flow phenomenon in the heart and brain［J］. Am J Physiol
［57］SEMERANO A，LAREDO C，ZHAO Y S，et al. Leuko⁃ Heart Circ Physiol，2018，315（3）：550-562
cytes，collateral circulation，and reperfusion in ischemic ［70］GULLOTTA G S，DE FEO D，FRIEBEL E，et al. Age⁃in⁃
stroke patients treated with mechanical thrombectomy［J］. duced alterations of granulopoiesis generate atypical neu⁃
Stroke，2019，50（12）：3456-3464 trophils that aggravate stroke pathology［J］. Nat Immunol，