Page 121 - 《南京医科大学学报》2026年第1期

第46卷第1期 邵燕婷，徐亭亭. 抑郁与胃食管反流病相关表型的遗传关联性分析［J］.
2026年1月 南京医科大学学报（自然科学版），2026，46（1）：112-122 · 115 ·

与NERD相关的有47个工具变量，删除离群值 P > 0.05，提示工具变量间不存在异质性。多效性评
后获得44个SNP。IVW法结果显示，OR值为1.003， 价显示MR⁃Egger回归分析截距与0相比差异有统计
95%CI 为 1.001~1.005，P=0.005，提示抑郁会导致 学意义（P < 0.05），优选MR⁃Egger同样提示抑郁可导
NERD 的风险升高，抑郁人群中患有NERD的风险是 致NERD风险升高，抑郁人群中患有NERD的风险是
正常人的1.003倍。MR⁃Egger、Weightedmedian、Simple 正常人的1.019倍。敏感性分析：留一法显示所有SNP
mode、Weighted mode 与 IVW 结果一致（图 1A）。结 在无效线右侧，提示本次MR分析结果稳健（图1D）。
果显示，抑郁会导致NERD的风险升高，抑郁人群患 2.3 GERD及其亚型与抑郁的反向MR分析结果
有 NERD 的风险是正常人的 1.003 倍。异质性检验 以 GERD、RE、NERD 为暴露因素，以抑郁为结

A Exposure/Outcome Method SNP（n） P OR（95%CI） Heterogeneity test Pleiotropy test
Depression/GERD IVW 45 <0.001 1.009（1.005-1.013） 0.098
MR⁃Egger 45 0.412 1.010（0.987-1.003） 0.081 0.947
Weighted median 45 0.004 1.009（1.003-1.014）
Simple mode 45 0.365 1.007（0.992-1.021）
Weighted mode 45 0.307 1.007（0.994-1.021）
Depression/RE IVW 40 0.278 1.001（0.999-1.003） 0.665
MR⁃Egger 40 0.737 0.997（0.983-1.012） 0.621 0.644
Weighted median 40 0.653 1.001（0.998-1.003）
Simple mode 40 0.553 0.998（0.993-1.004）
Weighted mode 40 0.535 0.998（0.993-1.004）
Depression/NERD IVW 44 0.005 1.003（1.001-1.005） 0.565
MR⁃Egger 44 0.006 1.019（1.006-1.032） 0.768 0.02
Weighted median 44 0.316 1.002（0.998-1.005）
Simple mode 44 0.668 1.002（0.995-1.009）
Weighted mode 44 0.603 1.002（0.995-1.009）
0.990 0.995 0 1.005 1.010

Protective factor Risk factor
B rs62535714 C rs7152906 D rs7551758
rs7551758 rs2568958 rs9536381
rs12919291 rs2418449 rs28541419
rs10913112 rs1021363 rs3807865
rs1367635 rs508502
rs17641524 rs10501696 rs76954012
rs7551758
rs28541419 rs2418449
rs150186873 rs2111592 rs12631196
rs4936275 rs1931388 rs843812
rs76954012 rs12631196 rs62535714
rs508502 rs30266 rs72948506
rs1931388 rs843812 rs61914045
rs1950829 rs6656912 rs6656912
rs12631196 rs9536381 rs30266
rs12967143 rs2111592
rs66511648 rs9831648 rs4141983
rs2214123 rs62535714 rs754287
rs6656912 rs10235664 rs10501696
rs59082935 rs754287 rs1369635
rs7152906 rs9529218 rs2214123
rs13037326 rs1950829 rs12919291
rs7725715 rs198457 rs13037326
rs2568958 rs12967143 rs7725715
rs7241572 rs198457
rs754287 rs12919291
rs4141983 rs4799949 rs59082935
rs10235664 rs17641524 rs3099439
rs1950829
rs198457 rs72948506
rs9831648 rs3099439 rs10913112
rs61914045 rs13037326 rs10235664
rs9364755 rs10913112 rs66511648
rs4936275
rs843812 rs28541419
rs3099439 rs2568958
rs4799949 rs508502 rs4799949
rs2418449 rs66511648 rs9364755
rs10501696 rs61914045 rs7241572
rs72948506 rs9364755 rs354155
rs354155 rs4936275 rs17641524
rs9536381 rs4141983 rs1021363
rs9529218 rs7241572 rs9831648
rs2232423 rs7725715 rs12967143
rs30266 rs1931388
rs3807865 rs3807865 rs7152906
rs1021363 rs2214123 rs9529218
rs2111592 rs1367635 rs2232423
AII AII AII
0.000 0.005 0.010 -0.001 0.000 0.001 0.002 0.003 0.000 0.002 0.004 0.006
Effect of depression on GERD Effect of depression on RE Effect of depression on NERD
A：Causal effect of depression on GERD and its subtypes. P < 0.05 indicates a causal relationship，and the OR value represents the strength of the
association（forest plot）. B：The impact of depression on GERD，with each point representing the robustness of the causal effect evaluated by the IVW method
after removing a single SNP（leave⁃one⁃out analysis）. C：The impact of depression on RE（leave⁃one⁃out analysis）. D：The impact of depression on
NERD（leave⁃one⁃out analysis）.
图1 抑郁与GERD、RE、NERD风险的因果关系
Figure 1 Causal relationship between depression and the risks of GERD，RE，and NERD