Page 125 - 《南京医科大学学报》2026年第1期

第46卷第1期 邵燕婷，徐亭亭. 抑郁与胃食管反流病相关表型的遗传关联性分析［J］.
2026年1月 南京医科大学学报（自然科学版），2026，46（1）：112-122 · 119 ·

A 2
Up⁃regulated DEG P -lg 1 0

Down⁃regulated DEG P -lg 2 1 0

（both sides） -lg 1 0 Brain_cortex Uterus Liver Ovary Thyroid Pancreas Spleen Prostate Lung Stomath Testis Bladder Vagina Pltultary Nerve_tibial
DEG P 2

Heart_lett_ventricle
Brain_spinal_cord_cervical_c⁃1
Kidney_cortex
Brain_cerebellum
Cells_EBV⁃transformed_lymphocytes
Brain_caudate_basal_ganglia
Fallopian_tube
Brain_frontal_cortex_BA9
Cervix_ectocervix
Brain_substantia_nigra
Brain_amygdala
Minor_salivary_gland
Artery_coronary
Skin_sun_exposed_lower_leg
Esophagus_mucosa
Skin_not_sun_exposed_suprapubic
Artery_tibial
Adipose_subcutaneous
Esophagus_muscularis
Breast_mammary_tissue
Adipose_visceral_omentum
Artery_aorta
Brain+putamen+basal_ganglia
Brain_nucleus_accumbens_basul_ganglia Brain_hypothalamus Brain_hippocampus Cervix_endocervix Heart_atrial_appendage Brain_cerebellar_hemisphere Whole_blood Adrenal_gland Small_intestine_terminal_ileum Colon_sigmoid Esophagus_gastroesophageal junction Colon_transverse Cells_cultured_fibroblasts Kidney_medulla
Brain_anterior_angulate_cortex_BA24
Muscle_skeletal
B 1.0
Up⁃regulated DEG P -lg 0.5
0.0
Down⁃regulated DEG P -lg 1.0
0.5
0.0
DEG （both sides） P -lg 1.0 Uterus Bladder Tnyrold Ovary Spleen Pancreas Lung Liver Stomath Pancreas Vagina Testis Pituitary
0.5
0.0
Brain_spinal_cord_cervical_c⁃1
Heart_atrial_appendage
Artery_coronary
Artery_tibial
Brain_anterior_cingulate_cortex_BA24 Brain_hypothalamus Brain_substatia_nigra Brain_amygdala Brain_hippocampus Small_intestine_terminal_ileum Kidney_conrtex Colon_sigmoid Esophagus_gastroesophageal_lunction Adrenal_gland Nerve+tibial Skin_sun_eexposed_lower_leg Adipose_subcutaneous
Adipose_visceral_omentum
Minor_salivary_gland
Whole_blood
Cervix_ectocervix
Brain_cerehellar_hemisphere
Esophagus_muscularis
Brain_cerebellum
Heart_left_ventricle
Brain_nuclevs_aceumbens_basal_ganglia
Muscle_skeletal
Colon_transverse
Esophagus_mucosa
Brain_putamen_basal_ganglia
Cells_EBV⁃transformed_lymphocytes
Cervix_endocervix
Kidney_medulla
Artery_aorta
Brain_fiontal_cortex_BA9
Breast_mammary_tissue
Skin_not_sun_exposed_suprapubic
Brain_caudate_basal_ganalia
Cells_cultured_fibroblasts
Brain_cortex
Fallopian_tube
C D Nucleosome organization
T cell receptor signaling pathway -lg（P） -lg（P）
T cell receptor signaling pathway GO_BP
5.5 12
Antigen receptor mediated signaling pathway Protein and complex subunit organization
5.0 10
GO_BP
4.5 Chromosome centromeric core domain 8
Nucleosome 4.0 6
Nucleosome 4
count GO_CC count
External side of plasma membrane GO_CC 4 DNA packaging complex 5
5 Protein DNA complex 10
Side of membrane 6
7 Structural constituent of chromatin
8 Protein heterodimerization activity GO_MF
Structural constituent of chromatin GO_MF 9
Structural molecule activity
0.02 0.04 0.06 0.1 0.2 0.3 0.4
Gene ratio Gene ratio
A：Co⁃enriched tissues of depression and GERD. B：Co⁃enrich tissues of depression and NERD. C：Co⁃enrichment pathway of depression and GERD
（GO analysis）. D：Co⁃enrichment pathways of depression and NERD（GO analysis）. BP：biological process；CC：cellular component；MF：molecular
function.
图4 抑郁、GERD、NERD的功能注释
Figure 4 Functional annotations of depression，GERD，and NERD