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第46卷第10期 李江鹏,唐立钧,李天女,等. F⁃FDG PET/CT代谢参数预测胃癌原发灶HER2低表达状态[J].
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2026年10月 南京医科大学学报(自然科学版),2026,46(10):1536-1544 ·1541 ·
A
B
C
A:A 76⁃year⁃old female patient with poorly differentiated adenocarcinoma of the gastric cardia,showing HER2 absent expression,IHC score 0,
TLG40%=123.4 g,TLG80%=1.43 g,CEA=2.86 ng/mL. B:A 64⁃year⁃old female patient with moderately differentiated adenocarcinoma of the gastric antrum,
exhibiting HER2 low expression,IHC score 1+,TLG40%=127.55 g,TLG80%=4.67 g,CEA=7.12 ng/mL. C:A 77⁃year⁃old male patient with poorly differen⁃
tiated adenocarcinoma of the gastric cardia,demonstrating HER2 high expression,IHC score 3+,TLG40%=34.42 g,TLG80%=9.16 g,CEA=34.10 ng/mL.
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图1 胃癌患者 F⁃FDG PET/CT显像图像
Figure 1 18 F⁃PDG PET/CT images of patients with gastric cancer
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表2 不同组胃癌患者的 F⁃FDG PET/CT 相关代谢参数比较
Table 2 Comparison of F⁃FDG PET/CT⁃derived metabolic parameters among different groups of gastric cancer patients
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[M(P25,P75)]
Variables HER2 absent expression(n=35) HER2 low expression(n=46) HER2 high expression(n=29) H P
MTV40% (cm ) 3.77(1.34,7.20) 4.67(2.07,8.62) a 10.70(6.12,23.42)00 22.070 <0.001
2
ab
MTV60% (cm ) 0.37(0.16,1.37) 0.83(0.43,2.09) a 3.48(1.59,4.85)00 29.519 <0.001
2
ab
MTV80% (cm ) 0.05(0.02,0.08) 0.17(0.06,0.27) a 0.64(0.37,1.05)00 55.418 <0.001
ab
2
TLG40% (g) 10.37(4.88,26.42) 16.81(6.79,35.32) a 60.51(30.22,132.95) 31.775 <0.001
ab
TLG60% (g) 1.28(0.46,4.97) 3.25(1.60,6.24) a 19.71(8.41,33.25)00 42.647 <0.001
ab
TLG80% (g) 0.15(0.09,0.30) 0.85(0.41,1.58) a 7.80(2.77,10.83)0 71.029 <0.001
ab
SUVmin 1.41(0.88,1.95) 1.32(0.99,1.63) a 1.18(0.78,1.76)00 ab 1.356 0.508
ab
SUVmean 3.16(2.34,4.21) 3.45(2.63,4.25) a 5.26(3.35,6.88)00 18.401 <0.001
ab
SUVmax 5.30(3.73,6.17) 07.27(5.54,11.73) a 19.10(11.48,22.00)0 58.162 <0.001
ab
HI 1.57(1.44,1.75) 2.21(1.92,2.73) a 3.30(3.11,3.87)00 77.203 <0.001
a:denotes a statistically significant difference compared to the HER2 absent expression group,with P < 0.0167;b:denotes a statistically signifi⁃
cant difference compared to the HER2 low expression group,with P < 0.0167. Post⁃hoc pairwise comparisons were performed using the Dunn test with
Bonferroni correction applied.
任意两组间差异均具有统计学意义(P均< 0.05),呈 趋势。该结果可能与本研究发现的HER2缺失表达
现 HER2 表达缺失组最低,HER2 高表达组最高的 组低分化印戒细胞癌比例更高,而大多数印戒细胞癌

