Page 32 - 《南京医科大学学报（自然科学版）》2026年第3期

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·340 · 南 京 医 科 大 学 学 报 2026年3月

A 20 B 100 C 150 D 40
T in cancer 15 CD8 + T in cancer 80 in cancer 100 T in Cancer 30
60
20
10
40
50
CD4 + 5 0 20 0 CD45RO + 0 FOXP3 + 10 0
-5 -20 -50 -10
1 2 1 2 1 2 1 2
E 300 F 150 G 300
in cancer 200 in cancer 100 in cancer 200

50
CTLA4 + 100 PD1 + 0 PDL1 + 100
0 -50 0
1 2 1 2 1 2
+
A：The relationship between CLEC5A protein expression and CD4 T cells infiltration alteration in GC tissues. B：The relationship between
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CLEC5A protein expression and CD8 T cells infiltration alteration in GC tissues. C：The relationship between CLEC5A protein expression and
+
+
CD45RO cells infiltration alteration in GC tissues. D：The relationship between CLEC5A protein expression and FOXP3 T cells infiltration alteration
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in GC tissues. E：The relationship between CLEC5A protein expression and CTLA4 cells infiltration alteration in GC tissues. F：The relationship
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between CLEC5A protein expression and PD1 cells infiltration alteration in GC tissues. G：The relationship between CLEC5A protein expression and
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PDL1 cells infiltration alteration in GC tissues. 1：Low or no CLEC5A score group；2：High CLEC5A score group.
图3 胃癌组织中CLEC5A蛋白表达与TIL浸润的关系
Figure 3 The relationship between CLEC5A protein expression and TIL infiltration alteration in GC tissues
A B C D
60 60 40 60
T in TIL 40 T in TIL 40 in TIL 30 in TIL 40
20
20
20
20
CD4 + 0 CD8 + 0 CD20 + 10 0 CD45RO + 0
-20 -20 -10 -20
1 2 1 2 1 2 1 2
E 300 F 100 G 300
in cancer 200 in TIL 80 in TIL 200
60
40
100
CTLA4 + 100 PD1 + 20 0 PDL1 + 0
0 -20 -100
1 2 1 2 1 2
+
A：The relationship between CLEC5A protein expression and CD4 T cells infiltration alteration in interstitial lymphocytes. B：The relationship
+
between CLEC5A protein expression and CD8 T cells infiltration alteration in interstitial lymphocytes. C：The relationship between CLEC5A protein
+
+
expression and CD45RO cells infiltration alteration in interstitial lymphocytes. D：The relationship between CLEC5A protein expression and FOXP3 T
+
cells infiltration alteration in interstitial lymphocytes. E：The relationship between CLEC5A protein expression and CTLA4 cells infiltration alteration
+
in interstitial lymphocytes. F：The relationship between CLEC5A protein expression and PD1 cells infiltration alteration in interstitial lymphocytes.
+
G：The relationship between CLEC5A protein expression and PDL1 cells infiltration alteration in interstitial lymphocytes. 1：Low or no CLEC5A score
group；2：High CLEC5A score group.
图4 间质淋巴细胞中CLEC5A蛋白表达与TIL浸润的关系
Figure 4 The relationship between CLEC5A protein expression and TILs infiltration alteration in interstitial lymphocytes
项研究表明它与肿瘤的预后相关 ［14-15］ 。而 CLEC5A CLEC5A mRNA 表达量显著高于癌旁组织。GEPIA
在 TME 中与一些免疫细胞浸润的相关性从未被报 数据库分析则显示 CLEC5A mRNA 表达量与 OS 无
道。本研究探讨了 CLEC5A 表达与 GC 患者预后及 相关性。随后对临床样本进行了 IHC 分析，发现胃
TIL 的相关性。首先用生物信息学方法挖掘了与 癌组织中 CLEC5A 蛋白的表达高于正常胃黏膜组

GC发生和发展相关的差异表达基因，选取CLEC5A 织。CLEC5A的表达与胃癌临床病理特征的关系表
作为一个显著差异表达基因，并发现其与 TIL 的关 明，CLEC5A 在肿瘤组织中上调与较低的 N 分期和
联尚未报道。TCGA 分析结果显示，胃癌组织中 较低的CEA水平显著相关。而CLEC5A在间质淋巴