Page 126 - 南京医科大学自然版

第46卷第5期
·748 · 南 京 医 科 大 学 学 报 2026年5月

selenium and manganese in the formation，diagnosis and trends［J］. Nat Rev Clin Oncol，2023，20（9）：624-639
treatment of cervical，endometrial and ovarian cancer［J］. ［26］ZHANG K，ZHU T T，QUAN X W，et al. Association be⁃
Int J Mol Sci，2023，24（13）：10887 tween blood heavy metals and lung cancer risk：a case ⁃
［11］JENKINS D J A，KITTS D，GIOVANNUCCI E L，et al. Se⁃ control study in China［J］. Chemosphere，2023，343：
lenium，antioxidants，cardiovascular disease，and all ⁃ 140200
cause mortality：a systematic review and meta⁃analysis of ［27］LE N T，PHAM Y T，LE C T，et al. A U⁃shaped associa⁃
randomized controlled trials［J］. Am J Clin Nutr，2020， tion between selenium intake and cancer risk［J］. Sci
112（6）：1642-1652 Rep，2024，14（1）：21378
［12］LUBINSKI J，LENER M R，MARCINIAK W，et al. Serum ［28］EPPLEIN M，BURK R F，CAI Q Y，et al. A prospective
essential elements and survival after cancer diagnosis［J］. study of plasma selenoprotein P and lung cancer risk
Nutrients，2023，15（11）：2611 among low⁃income adults［J］. Cancer Epidemiol Biomark⁃
［13］DEMIRCAN K，BENGTSSON Y，SUN Q，et al. Serum se⁃ ers Prev，2014，23（7）：1238-1244
lenium，selenoprotein P and glutathione peroxidase 3 as ［29］OHLINGER J，VORDERMARK D，OSTHEIMER C，et al.
predictors of mortality and recurrence following breast Change in the serum selenium level of patients with non⁃
cancer diagnosis：a multicentre cohort study［J］. Redox metastatic and metastatic non ⁃ small cell lung cancer
Biol，2021，47：102145 （NSCLC）during radiotherapy as a predictive factor for
［14］MA X，SHA Z P，LI Y Z，et al. Temporal⁃spatial character⁃ survival［J］. Al，2025，201（6）：616-626
istics and sources of heavy metals in bulk deposition ［30］NIE S Q，HE X，SUN Z T，et al. Selenium speciation⁃de⁃
across China［J］. Sci Total Environ，2024，926：171903 pendent cancer radiosensitization by induction of G2/M
［15］GORINI F，SABATINO L，PINGITORE A，et al. Seleni⁃ cell cycle arrest and apoptosis［J］. Front Bioeng Biotech⁃
um：an element of life essential for thyroid function［J］. nol，2023，11：1168827
Molecules，2021，26（23）：7084 ［31］MA J，HUANG J，SUN J L，et al. L⁃Se⁃methylselenocyste⁃
［16］SCHOMBURG L. Selenoprotein P⁃selenium transport pro⁃ ine sensitizes lung carcinoma to chemotherapy［J］. Cell
tein，enzyme and biomarker of selenium status［J］. Free Prolif，2021，54（5）：e13038
Radic Biol Med，2022，191：150⁃163 ［32］LIU S W，WEI W F，WANG J L，et al. Theranostic appli⁃
［17］QI Z Q，DUAN A，NG K. Selenosugar，selenopolysaccha⁃ cations of selenium nanomedicines against lung cancer［J］.
ride，and putative selenoflavonoid in plants［J］. Compr J Nanobiotechnology，2023，21（1）：96
Rev Food Sci Food Saf，2024，23（3）：e13329 ［33］CHAN L S，LIU J，LI M S C，et al. Selenite as a dual apop⁃
［18］ZHANG F，LI X L，WEI Y M. Selenium and selenopro⁃ totic and ferroptotic agent synergizes with EGFR and
teins in health［J］. Biomolecules，2023，13（5）：799 KRAS inhibitors with epigenetic interference［J］. Clin
［19］BURK R F，HILL K E. Regulation of selenium metabo⁃ Epigenetics，2023，15（1）：36
lism and transport［J］. Annu Rev Nutr，2015，35：109-134 ［34］XU X，HOU Y Q，LIN S M，et al. Sodium selenite inhibits
［20］MOJADADI A，AU A，SALAH W，et al. Role for selenium proliferation of lung cancer cells by inhibiting NF⁃κB nu⁃
in metabolic homeostasis and human reproduction［J］. clear translocation and down⁃regulating PDK1 expression
Nutrients，2021，13（9）：3256 which is a key enzyme in energy metabolism expression［J］.
［21］MINICH W B. Selenium metabolism and biosynthesis of J Trace Elem Med Biol，2023，78：127147
selenoproteins in the human body［J］. Biochemistry， ［35］ZHU Y，PU Q，ZHANG Q Y，et al. Selenium⁃binding pro⁃
2022，87（Suppl 1）：S168-S102 tein 1 inhibits malignant progression and induces apopto⁃
［22］BRIGELIUS⁃FLOHÉ R，FLOHÉ L. Regulatory phenome⁃ sis via distinct mechanisms in non⁃small cell lung can⁃
na in the glutathione peroxidase superfamily［J］. Antioxid cer［J］. Cancer Med，2023，12（16）：17149-17170
Redox Signal，2020，33（7）：498-516 ［36］SCHRAUZER G N，WHITE D A，SCHNEIDER C J. Can⁃
［23］LEE J，ROH J L. Targeting GPX4 in human cancer：Impli⁃ cer mortality correlation studies ⁃ Ⅲ ：statistical associa⁃
cations of ferroptosis induction for tackling cancer resil⁃ tions with dietary selenium intakes［J］. Bioinorg Chem，
ience［J］. Cancer Lett，2023，559：216119 1977，7（1）：23-31
［24］HANDY D E，LOSCALZO J. The role of glutathione per⁃ ［37］CABRAL M，KUXHAUS O，EICHELMANN F，et al. Trace
oxidase⁃1 in health and disease［J］. Free Radic Biol Med， element profile and incidence of type 2 diabetes，cardio⁃
2022，188：146⁃161 vascular disease and colorectal cancer：results from the
［25］LEITER A，VELUSWAMY R R，WISNIVESKY J P. The EPIC⁃Potsdam cohort study［J］. Eur J Nutr，2021，60（6）：
global burden of lung cancer：current status and future 3267-3278