Page 94 - 南京医科大学自然版
P. 94
第46卷第5期
·716 · 南 京 医 科 大 学 学 报 2026年5月
associated macrophages expression in gastric cancer and [29]INAGAKI K,KUNISHO S,TAKIGAWA H,et al. Role of
its clinical pathological relationship[J]. Medicine,2020, tumor ⁃ associated macrophages at the invasive front in
99(17):e19839 human colorectal cancer progression[J]. Cancer Sci,
[24]PARK J Y,SUNG J Y,LEE J,et al. Polarized CD163 + 2021,112(7):2692-2704
tumor ⁃ associated macrophages are associated with in⁃ [30]GAMBARDELLA V,CASTILLO J,TARAZONA N,et al.
creased angiogenesis and CXCL12 expression in gastric The role of tumor ⁃ associated macrophages in gastric
cancer[J]. Clin Res Hepatol Gastroenterol,2016,40(3): cancer development and their potential as a therapeutic
357-365 target[J]. Cancer Treat Rev,2020,86:102015
[25]SU C Y,FU X L,DUAN W,et al. High density of CD68 + [31]ZHOU W X,ZHANG Y Y,HE F,et al. Abundance of
tumor⁃associated macrophages predicts a poor prognosis CD163 ⁃ positive tumor ⁃ associated macrophages in the
in gastric cancer mediated by IL⁃6 expression[J]. Oncol early gastric cancer predicts the recurrence after curative
Lett,2018,15(5):6217-6224 resection[J]. Dig Dis,2020,38(6):458-465
[26] YIN S C,HUANG J Y,LI Z,et al. The prognostic and [32]YANAGAWA N,SHIKANAI S,SUGAI M Y,et al. Prog⁃
clinicopathological significance of tumor ⁃ associated nostic and predictive value of CD163 expression and the
macrophages in patients with gastric cancer:a meta⁃analy⁃ CD163/CD68 expression ratio for response to adjuvant
sis[J]. PLoS One,2017,12(1):e0170042 chemotherapy in patients with surgically resected lung
[27] PANTANO F,BERTI P,GUIDA F M,et al. The role of squamous cell carcinoma[J]. Thorac Cancer,2023,14
macrophages polarization in predicting prognosis of (20):1911-1920
radically resected gastric cancer patients[J]. J Cell Mol [33] CHEN X Y,CHEN J,ZHANG W Y,et al. Prognostic
Med,2013,17(11):1415-1421 value of diametrically polarized tumor⁃associated macro⁃
+
[28]YANG C G,WEI C,WANG S Y,et al. Elevated CD163 / phages in multiple myeloma[J]. Oncotarget,2017,8
+
CD68 ratio at tumor invasive front is closely associated (68):112685-112696
with aggressive phenotype and poor prognosis in colorec⁃ (收稿:2026-01-18;修回:2026-04-11;录用:2026-04-16)
tal cancer[J]. Int J Biol Sci,2019,15(5):984-998 (本文编辑:蒋 莉)

