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第46卷第6期 南京医科大学学报(自然科学版)
2026年6月 Journal of Nanjing Medical University(Natural Sciences) ·799 ·
·专题研究:肝脏疾病·
肝转移瘤 F⁃FDG PET/CT研究进展与展望
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孙 庆,梁 迪,何 健 *
南京医科大学鼓楼临床医学院核医学科,江苏 南京 210008
[摘 要] 肝脏是肿瘤转移的常见部位,肝转移瘤常继发于结直肠癌、胰腺癌、黑色素瘤、肺癌和乳腺癌等。在所有恶性肿瘤
转移中,肝转移占比近25%,肝转移患者的1年生存率为15.1%。肝转移瘤的早期诊断和精准治疗对改善患者预后至关重要。
氟⁃2⁃脱氧葡萄糖( F⁃fluoro⁃deoxy⁃D⁃glucose,F⁃FDG)PET/CT作为一种功能代谢与解剖结构相结合的影像学检查技术,在肝
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转移瘤的诊断、分期、治疗方案制定等方面发挥着越来越重要的作用。文章综述了近年来 F⁃FDG PET/CT在肝转移瘤研究中
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的进展,包括在肝转移瘤诊断、鉴别诊断、治疗前评估、疗效评估、预后预测等方面的应用,与其他影像学方法比较的优劣势,在
延迟成像、图像优化等技术方面的新进展,在诊断某些疾病时的陷阱,在引导放疗时的作用等。最后,总结了人工智能技术在
肝转移瘤诊疗中的应用,并对 F⁃FDG PET/CT应用于肝转移瘤的发展方向进行了展望。
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[关键词] 18 氟⁃2⁃脱氧葡萄糖;肝转移瘤;PET/CT;人工智能
[中图分类号] R735.7;R730.44 [文献标志码] A [文章编号] 1007⁃4368(2026)06⁃799⁃10
doi:10.7655/NYDXBNSN251477
Progress and prospects of F⁃FDG PET/CT in liver metastases
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SUN Qing,LIANG Di,HE Jian *
Department of Nuclear Medicine,Drum Tower Clinical Medical College,Nanjing Medical University,Nanjing
210008,China
[Abstract] The liver is a common site for tumor metastases. Liver metastases often occur secondary to malignancies including
colorectal cancer,pancreatic cancer,melanoma,lung cancer,and breast cancer,accounting for nearly 25% of all cancer metastases,
and the 1 ⁃ year survival rate for all patients with liver metastases is 15.1% . Early diagnosis and precise treatment are crucial for
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improving patient prognosis. As an imaging technique that combines functional metabolism with anatomical structure,F⁃fluoro⁃deoxy⁃
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D⁃glucose( F⁃FDG)PET/CT plays an increasingly important role in the diagnosis,staging,and treatment planning of liver metastases.
This article reviews recent advances in 18 F ⁃ FDG PET/CT research on liver metastases,including its applications in diagnosis,
differential diagnosis,pre ⁃ treatment evaluation,efficacy assessment,and prognosis prediction;its advantages and disadvantages in
comparative imaging;new technological developments such as delayed imaging and image optimization;diagnostic pitfalls in certain
diseases;and its role in guiding radiotherapy. Finally,it summarizes the application of artificial intelligence technology in the diagnosis
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and treatment of liver metastases and provides prospects on the future development directions of F⁃FDG PET/CT in this field.
[Key words] 18 F⁃fluoro⁃deoxy⁃D⁃glucose;liver metastases;PET/CT;artificial intelligence
[J Nanjing Med Univ,2026,46(06):799⁃808]
[2]
肝脏是常见的肿瘤转移靶器官,肝转移瘤比肝 分泌癌及其他不太常见的亚型 。一项涵盖2010—
原发肿瘤更多见,肝脏独特的细胞和结构组成是其适 2015年针对肝转移瘤的流行病学调查显示,在240万
合肿瘤细胞形成转移灶的主要原因 。腺癌是大多 癌症患者中,5.14%在诊断时已出现肝转移,从原发
[1]
数转移性肿瘤的病理类型,还有鳞状细胞癌、神经内 灶看,中青年(20~50岁)女性以乳腺癌最常见,男性
以结直肠癌最常见,老年患者除肺癌、胰腺癌和结直
[基金项目] 国家重点研发计划(2020YFA0713800)
肠癌这些常见原发癌外,食管、胃、小肠、黑色素和膀
∗
通信作者(Corresponding author),E ⁃ mail:hjxueren@126.com
(ORCID:0000⁃0001⁃8140⁃4610) 胱来源肿瘤的比例增加。生存分析显示,肝转移瘤患

