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第46卷第6期
·868 · 南 京 医 科 大 学 学 报 2026年6月

A B
Identified lipids 1.0
1.000 0.898 0.882 0.894 0.575 0.897 0.899 0.919 0.909 0.883 0.861 0.862 0.877 0.958 0.909 0.905 0.888 0.899 0.906 0.873 0.874 0.859 0.878 A1
PC 233 0.9
SM 218 0.898 1.000 0.899 0.941 0.564 0.946 0.964 0.938 0.932 0.795 0.895 0.920 0.893 0.858 0.913 0.961 0.954 0.928 0.950 0.894 0.930 0.921 0.927 A2
0.8
EtherPC 200 0.882 0.899 1.000 0.937 0.544 0.943 0.921 0.941 0.925 0.813 0.955 0.940 0.972 0.848 0.949 0.921 0.934 0.953 0.922 0.950 0.957 0.953 0.959 A3
EtherPE 192 0.7
0.894 0.941 0.937 1.000 0.566 0.959 0.956 0.952 0.924 0.797 0.927 0.938 0.929 0.846 0.942 0.943 0.958 0.951 0.946 0.937 0.952 0.947 0.956 A5
TG 181 0.6
CL 108 0.575 0.564 0.544 0.566 1.000 0.568 0.570 0.574 0.580 0.545 0.506 0.510 0.526 0.582 0.558 0.550 0.560 0.556 0.590 0.548 0.531 0.513 0.532 A4
PE 91 0.897 0.946 0.943 0.959 0.568 1.000 0.954 0.960 0.920 0.815 0.938 0.928 0.931 0.867 0.954 0.943 0.963 0.951 0.948 0.956 0.954 0.948 0.955 A6
73
DG A7
64 0.899 0.946 0.921 0.956 0.570 0.954 1.000 0.953 0.935 0.794 0.911 0.932 0.928 0.855 0.929 0.965 0.966 0.944 0.951 0.918 0.945 0.935 0.944
PI
55 0.919 0.938 0.941 0.952 0.574 0.960 0.953 1.000 0.933 0.851 0.929 0.942 0.943 0.889 0.953 0.945 0.963 0.961 0.959 0.945 0.955 0.944 0.954 A8
LPC
51
OxFA 0.909 0.932 0.925 0.924 0.580 0.920 0.935 0.933 1.000 0.813 0.895 0.904 0.919 0.896 0.920 0.934 0.926 0.937 0.928 0.901 0.930 0.920 0.931 A9
37
FA
34 0.883 0.795 0.813 0.797 0.545 0.815 0.794 0.851 0.813 1.000 0.793 0.794 0.808 0.877 0.816 0.798 0.805 0.833 0.825 0.817 0.798 0.781 0.800 A10
Cer_NS 34 0.861 0.895 0.955 0.927 0.506 0.938 0.911 0.929 0.895 0.793 1.000 0.836 0.957 0.821 0.943 0.920 0.917 0.941 0.909 0.926 0.951 0.952 0.950 B1
Ontology HexCer_NS 27 0.862 0.920 0.940 0.938 0.510 0.928 0.932 0.842 0.904 0.794 0.936 1.000 0.934 0.811 0.923 0.939 0.940 0.935 0.932 0.921 0.954 0.953 0.952 B2
30
OxPC
CAR
Hex3Cer 18 0.877 0.893 0.972 0.929 0.526 0.931 0.918 0.943 0.919 0.808 0.957 0.934 1.000 0.846 0.950 0.919 0.926 0.950 0.909 0.938 0.951 0.950 0.955 B3
18
LPE 0.958 0.858 0.848 0.846 0.582 0.867 0.855 0.889 0.896 0.877 0.821 0.811 0.846 1.000 0.870 0.858 0.853 0.878 0.879 0.857 0.836 0.817 0.840 B4
17
EtherLPE 14 0.909 0.913 0.949 0.942 0.558 0.954 0.929 0.953 0.920 0.816 0.943 0.923 0.950 0.870 1.000 0.933 0.926 0.945 0.924 0.941 0.943 0.938 0.944 B5
PG 14 B6
Cer_MDS 13 0.905 0.961 0.921 0.943 0.550 0.943 0.865 0.945 0.934 0.798 0.920 0.939 0.919 0.858 0.933 1.000 0.951 0.935 0.948 0.903 0.942 0.936 0.941
0.888 0.954 0.934 0.958 0.560 0.963 0.966 0.963 0.926 0.805 0.917 0.940 0.926 0.853 0.926 0.951 1.000 0.953 0.953 0.939 0.956 0.948 0.955 B7
HexCer_AP 12
Cer_AP 12 0.899 0.928 0.953 0.951 0.556 0.951 0.944 0.961 0.937 0.822 0.941 0.935 0.950 0.878 0.945 0.935 0.953 1.000 0.952 0.949 0.959 0.952 0.960 B8
LPI 11 0.906 0.950 0.922 0.946 0.590 0.948 0.951 0.959 0.928 0.825 0.909 0.932 0.909 0.879 0.924 0.948 0.953 0.952 1.000 0.920 0.943 0.932 0.939 B9
Hex2Cer 10
0.873 0.894 0.950 0.937 0.548 0.956 0.918 0.945 0.901 0.817 0.926 0.921 0.938 0.857 0.941 0.903 0.939 0.949 0.920 1.000 0.944 0.940 0.945 B10
HexCer_NDS 10
NAE 9 0.874 0.930 0.957 0.952 0.531 0.954 0.945 0.955 0.930 0.798 0.951 0.954 0.951 0.836 0.943 0.942 0.956 0.959 0.943 0.944 1.000 0.988 0.990 QC1
OxPE 9
0.859 0.921 0.953 0.947 0.513 0.948 0.935 0.944 0.920 0.781 0.952 0.953 0.950 0.817 0.938 0.936 0.948 0.952 0.932 0.940 0.988 1.000 0.988 QC2
HexCer_HDS 9
0.878 0.927 0.959 0.956 0.532 0.955 0.944 0.954 0.931 0.800 0.950 0.952 0.955 0.840 0.944 0.941 0.955 0.960 0.939 0.945 0.990 0.988 1.000 QC3
0 30 60 90 120 150 180 210 240
A1 A2 A3 A5 A4 A6 A7 A8 A9 B1 B2 B3 B4 B5 B6 B7 B8 B9
Number of lipids A10 B10 QC1 QC2 QC3
A：Classification of identified lipids. B：Correlation coefficient of lipid expression levels among samples.
图2 CO⁃CPP组与CO⁃PPP组的脂质分类及相关性分析
Figure 2 Lipid classification and correlation analysis between the CO⁃CPP group and the CO⁃PPP group
A B
24 3
25
20 18
Number 15 Type
Down
10
5 Up
0
2
CO⁃CPP/CO⁃PPP
P Regulation type
⁃log Unchange
Up
Down
1

0
-2 -1 0 1 2
log2 FC（CO⁃CPP/CO⁃PPP）
A：Differences in lipid quantity. B：Volcano plot of lipid differences.
图3 CO⁃CPP组与CO⁃PPP组组间差异脂质数量柱状图及火山图
Figure 3 Column chart and volcano plot of lipid quantity differences between the CO⁃CPP group and the CO⁃PPP group