Page 28 - 南京医科大学学报自然科学版
P. 28
第41卷第12期
·1734 · 南 京 医 科 大 学 学 报 2021年12月
产热。进一步机制探究发现,脂肪产热的关键基因 brown adipose tissues[J]. Aging Cell,2011,10(6):996-
PRDM16是miR⁃190的直接靶基因,miR⁃190通过对 1010
PRDM16的负调控抑制脂肪细胞产热。因此直接调 [6] BANK H V,KIRSH C,SIMCOX J. Aging adipose:depot
控PRDM16表达可能对miR⁃190诱导的脂肪细胞产 location dictates age ⁃ associated expansion and dysfunc⁃
tion[J]. Ageing Res Rev,2021,67(5):1-11
热下降有显着抑制作用。
[7] ALSA B,SINHA C. Obesity and aging:molecular mecha⁃
最后,在衰老小鼠中通过 miR⁃190 antagomir 抑
nisms and therapeutic approaches[J]. Ageing Res Rev,
制脂肪组织中miR⁃190的表达,结果显示,抑制miR⁃
2021,67(986):1-23
190 的表达后,衰老小鼠的能量消耗和耗氧量都得 [8] 尹 立 平 ,王 龙 ,吕 珊 ,等. 11β ⁃ HSD1 抑 制 剂
到改善提升,脂肪组织中脂滴缩小,形态得到明显 BVT.2733 对肥胖小鼠多器官组织代谢与炎症相关基
改观,并且衰老诱导的产热相关基因的下降受到抑 因表达的影响[J]. 南京医科大学学报(自然科学版),
制。综上所述,本研究为衰老相关代谢紊乱提供了 2019,39(12):1716-1722
理论支持,并为其提供了可能的潜在治疗干预策 [9] DOOLEY J,LISTON A. Molecular control over thymic in⁃
略,但是还需要进一步研究 miR⁃190 在脂肪组织中 volution:from cytokines and microRNA to aging and adi⁃
pose tissue[J]. Eur J Immunol,2012,42(5):1073-
的其余靶点和作用。
1079
[参考文献] [10] YU Y,CAO X C. miR⁃190⁃5p in human diseases[J]. Can⁃
[1] LYU Y,WEAVER K J,SHAUKAT H A,et al. Drosophila cer Cell Int,2019,19(1):257-266
serotonin 2A receptor signaling coordinates central meta⁃ [11] YU Y,LUO W,YANG Z J,et al. miR ⁃ 190 suppresses
bolic processes to modulate aging in response to nutrient breast cancer metastasis by regulation of TGF ⁃ β ⁃ indu⁃
choice[J]. Elife,2021,10(1):1-25 cedepithelial ⁃ mesenchymal transition[J]. Mol Cancer,
[2] LI Z C,XU K,ZHAO S,et al. SPATA4 improves aging⁃in⁃ 2018,17(1):70-82
duced metabolic dysfunction through promotion of preadi⁃ [12] DIAO Z Q,JI Q Z,WU Z M,et al. SIRT3 consolidates het⁃
pocyte differentiation and adipose tissue expansion[J]. erochromatin and counteracts senescence[J]. Nucleic Ac⁃
Aging Cell,2021,20(1):1-12 ids Res,2021,49(8):4203-4219
[3] MARTOCCHIA A,STEFANELLI M,FALASCHI G M,et [13] 戴春梅,林 桐,罗文威,等. 应激性衰老导致血管内皮
al. Recent advances in the role of cortisol and metabolic 细胞能量代谢及线粒体功能异常的研究[J]. 中国科技
syndrome in age⁃related degenerative diseases[J]. Aging 论文,2019,14(8):867-873
Clin Exp Res,2016,28(1):17-23 [14] COHEN P,LEVY J D,ZHANG Y Y,et al. Ablation of
[4] DOU H J,FEHER A,DAVILA A C,et al. Role of adipose PRDM16 and beige adipose causes metabolic dysfunction
tissue endothelial ADAM17 in age⁃related coronary micro⁃ and a subcutaneous to visceral fat switch[J]. Cell,2014,
vascular dysfunction[J]. Arterioscler ThrombVasc Biol, 156(1⁃2):304-316
2017,37(6):1180-1193 [15] SCHWALIE P C,DONG H,ZACHARA M,et al. A stro⁃
[5] LIN L G,SAHA P K,MA X J,et al. Ablation of ghrelin re⁃ mal cell population that inhibits adipogenesis in mammali⁃
ceptor reduces adiposity and improves insulin sensitivity an fat depots[J]. Nature,2018,559(7712):103-108
during aging by regulating fat metabolism in white and [收稿日期] 2021-07-30