Page 127 - 南京医科大学学报自然科学版

第41卷第5期 南京医科大学学报（自然科学版）
2021年5月 Journal of Nanjing Medical University（Natural Sciences） ·757 ·

·影像医学·

FFRCT联合斑块特征与心肌灌注显像对冠心病患者主要不良心

脏事件预测效能的比较

薛秋苍 ，徐 怡 ，孙欣杰 ，许智惠 ，朱晓梅 ，祝因苏 ，施海彬 1
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1 南京医科大学第一附属医院放射科，心内科，江苏 南京 210029
［摘 要］ 目的：比较冠脉CT血流储备分数（CT⁃fractional flow reserve，FFRCT ）联合斑块特征与心肌灌注显像（myocardial perfu⁃
sion imaging，MPI）对冠心病（coronary artery disease，CAD）患者主要不良心脏事件（major adverse cardiovascular events，MACE）的
预测效能。方法：回顾性分析南京医科大学第一附属医院80例在3个月内完成CT血管成像（coronary computed tomography an⁃
giography，CCTA）及MPI并有完整随访资料的患者，测量FFRCT值及斑块定量特征值、总负荷积分、总积分差、相位标准差（stan⁃
dard deviation，SD）及相位直方图带宽（band width，BW）等影像参数，比较无事件组与事件组之间影像参数的差异，绘制受试者
工作特征（receiver operating characteristic，ROC）曲线比较两种方法对MACE的预测效能。结果：11例发生MACE。与无事件组
相比，事件组的FFRCT更低（P=0.009）、斑块更长（P=0.007）、非钙化斑块体积更大（P=0.026）、静息状态下舒张期SD及BW更低
（P＜0.05）。ROC曲线分析示，FFRCT及斑块长度对MACE的曲线下面积为0.80、0.81，SD及BW的曲线下面积为0.62、0.56。结
论：FFRCT联合斑块特征对CAD患者发生MACE的预测效能优于MPI。
［关键词］ 冠脉CT血管成像；血流储备分数；冠脉斑块特征；主要不良心脏事件；心肌灌注显像
［中图分类号］ R816.2 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）05⁃757⁃06
doi：10.7655/NYDXBNS20210522

Myocardial perfusion imaging versus FFR CT and atherosclerosis plaque characteristics in
predicting major adverse cardiac events in patients with coronary artery disease
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XUE Qiucang ，XU Yi ，SUN Xinjie ，XU Zhihui ，ZHU Xiaomei ，ZHU Yinsu ，SHI Haibing
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1 Department of Radiology，Department of Cardiology，the First Affiliated Hospital of Nanjing Medical University，
Nanjing 210029，China

［Abstract］ Objective：This study aims to analyze the predictive value of fractional flow reserve derived from coronary CTA（FFRCT ）
and plaque characteristics for major adverse cardiac events（MACE）in patients with coronary artery disease（CAD），and compare with
myocardial perfusion imaging（MPI）. Methods：Eighty patients with suspected CAD patients who underwent coronary CTA（CCTA）
and MPI within 3 months were retrospectively enrolled and followed up. Measurement parameters included FFRCT，atherosclerosis
plaque characteristics，summed stress score，summed difference score，phase standard deviation（SD），phase histogram bandwidth
（BW）. The differences of indicators were compared between positive MACE group and negative MACE groups. ROC curve analysis
was performed to evaluate the predictive value of FFRCT combined with plaque characteristics and MPI for MACE. Results：MACE
occurred in 11 patients. FFRCT，rest diastole SD（RDSD）and rest diastole BW（RDBW）in positive MACE group were significantly
lower than that in negative MACE group（all P＜0.05）. Plaque length and non ⁃ calcified volume in patients with MACE were
significantly higher（all P＜0.05）. The AUC of FFRCT and plaque length for prediction of MACE was 0.80 and 0.81，while the
predictive value of RDSD and RDBW was 0.62 and 0.56，respectively. Conclusion：FFRCT and plaque characteristics demonstrated a
higher predictive value for MACE than phase analysis of MPI in CAD patients.
［Key words］ CCTA；fractional flow reserve；plaque characteristics；MACE；MPI
［J Nanjing Med Univ，2021，41（05）：757⁃762］