Page 101 - 南京医科大学学报自然科学版

第41卷第8期 南京医科大学学报（自然科学版）
2021年8月 Journal of Nanjing Medical University（Natural Sciences） ·1203 ·

·临床医学·

术中冷冻消融和冷热复合消融治疗不可切除胰腺癌的临床研究

钱祝银 ，张 彬 ，陈奕秋 ，吴迎春 ，顾玉青 ，朱一超 2
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南京医科大学第二附属医院胰腺中心，江苏 南京 210003；南京医科大学生理学系，江苏 南京 211166；南京医科大学
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第二附属医院超声医学科，江苏 南京 210003
［摘 要］ 目的：比较术中冷冻消融（intraoperative cryoablation therapy，IOCT）和冷热复合消融（intraoperative combined cryoab⁃
lation and hyperthermia，ICCH）治疗不可切除胰腺癌的安全性和有效性。方法：南京医科大学第二附属医院胰腺中心收治的不
可切除胰腺癌患者，分为IOCT组（101例）与ICCH组（35例），分析患者临床资料，对比手术方法，分组对比术后并发症发生率、
生存率、肿瘤指标及疼痛评分。结果：与IOCT组相比，ICCH组术中出血量更少，术后禁食时间更短（P < 0.01）。ICCH组术后
并发症发生率、严重程度均低于 IOCT 组（P < 0.05）。胰头癌患者术后 1 年内的生存率，ICCH 组显著高于 IOCT 组（P=0.034）。
结论：ICCH较IOCT对不可切除胰腺癌的治疗效率更高，风险更小，并发症发生率更低。
［关键词］ 不可切除胰腺癌；冷热复合消融；术后并发症；生存期
［中图分类号］ R735.9 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）08⁃1203⁃05
doi：10.7655/NYDXBNS20210815

The clinical study of intraoperative cryoablation therapy and intraoperative combined
cryoablation and hyperthermia in the treatment of unresectable pancreatic cancer

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QIAN Zhuyin ，ZHANG Bin ，CHEN Yiqiu ，WU Yingchun ，GU Yuqing ，ZHU Yichao 2
Pancreas Center，the Second Affiliated Hospital of Nanjing Medical University，Nanjing 210003；Department of
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Physiology，Nanjing Medical University，Nanjing 211166；Ultrasound Department，the Second Affiliated Hospital of
Nanjing Medical University，Nanjing 210003，China
［Abstract］ Objective：To comparethe therapeutic efficiency and risk of intraoperative cryoablation therapy （IOCT）and
intraoperative combined cryoablation and hyperthermia（ICCH）in the treatment of unresectable pancreatic cancer. Methods：Patients
with unresectable pancreatic cancer admitted to the Pancreatic Center of the Second Affiliated Hospital of Nanjing Medical University
were divided into two groups：IOCT group（101 cases）and ICCH group（35 cases）. The clinical data of patients were analyzed and
surgical methods were compared. The incidence of postoperative complications，survival rate，tumor indexes and pain scores were
compared in groups. Results：Compared with IOCT group，the intraoperative blood loss was less in ICCH group（P < 0.01）. The
postoperative fasting time in ICCH group was shorter than that in IOCT group（P < 0.01）. The incidence and severity of postoperative
complications in ICCH group were lower than those in IOCT group（P < 0.05）. The 1⁃year survival rate of patients with pancreatic head
carcinoma was significantly higher in ICCH group than in IOCT group（P=0.034）. Conclusion：ICCH is more effective in the treatment
of unresectable pancreatic cancer，with lower risk and lower complication rate than IOCT.
［Key words］ unresectable pancreatic cancer；intraoperative combined cryoablation and hyperthermia；postoperative complications；
survival rate
［J Nanjing Med Univ，2021，41（08）：1203⁃1207］

［基金项目］ 南京市卫生科技发展专项资金项目一般性课题（YKK18188），南京医科大学科技发展基金一般项目（NMUB
2019044，NMUB2019045，NMUB2019059，NMUB2019060）
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通信作者（Corresponding author），E⁃mail：qianzhusilver@163.com