Page 22 - 南京医科大学学报自然科学版
P. 22

第43卷第1期
               · 16  ·                           南 京    医 科 大 学 学         报                        2023年1月


              YAP 和 EEF1A2 参与肝癌转移调控的理解,有可能                      [13] YANG S,LU M,CHEN Y,et al. Overexpression of eu⁃
              为抗肝癌转移提供新的治疗靶标。                                        karyotic elongation factor 1 alpha ⁃ 2 is associated with
                                                                     poorer prognosis in patients with gastric cancer[J]. J Can⁃
             [参考文献]
                                                                     cer Res Clin Oncol,2015,141(7):1265-1275
             [1] LLOVET J M,KELLEY R K,VILLANUEVA A,et al. He⁃  [14] SCAGGIANTE B,DAPAS B,BONIN S,et al. Dissecting
                   patocellular carcinoma[J]. Nat Rev Dis Primers,2021,7  the expression of EEF1A1/2 genes in human prostate can⁃
                  (1):6                                              cer cells:the potential of EEF1A2 as a hallmark for pros⁃
             [2] ZANCONATO F,CORDENONSI M,PICCOLO S. YAP/            tate transformation and progression[J]. Br J Cancer,
                   TAZ at the roots of cancer[J]. Cancer Cell,2016,29(6):  2012,106(1):166-173
                   783-803                                      [15] HU D M,XU C,ZHU Q. eEF1A2 protein expression cor⁃
             [3] GIUDICI F,PETRACCI E,NANNI O,et al. Elevated lev⁃   relates with lymph node metastasis and decreased surviv⁃
                   els of eEF1A2 protein expression in triple negative breast  al in pancreatic ductal adenocarcinoma[J]. Hepato gas⁃
                   cancer relate with poor prognosis[J]. PLoS One,2019,14  troenterology,2013,60(124):870-875
                  (6):e0218030                                  [16] WANG S,LI H,WANG G,et al. Yes⁃associated protein
             [4] AMIRI A,NOEI F,JEGANATHAN S,et al. eEF1A2 acti⁃    (YAP)expression is involved in epithelial⁃mesenchymal
                   vates Akt and stimulates Akt ⁃ dependent actin remodel⁃  transition in hepatocellular carcinoma[J]. Clin Transl On⁃
                   ing,invasion and migration[J]. Oncogene,2007,26   col,2016,18(2):172-177
                  (21):3027-3040                                [17] HUANG Z,ZHOU J K,WANG K,et al. PDLIM1 inhibits
             [5] QIU F N,HUANG Y,CHEN D Y,et al. Eukaryotic elon⁃    tumor metastasis through activating Hippo signaling in he⁃
                   gation factor⁃1α 2 knockdown inhibits hepatocarcinogene⁃  patocellular carcinoma[J]. Hepatology,2020,71(5):
                   sis by suppressing PI3K/Akt/NF⁃κB signaling[J]. World  1643-1659
                   J Gastroenterol,2016,22(16):4226-4237        [18] HAYASHI H,HIGASHI T,YOKOYAMA N,et al. An im⁃
             [6] PELLEGRINO R,CALVISI D F,NEUMANN O,et al.           balance in TAZ and YAP expression in hepatocellular
                   EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR⁃de⁃  carcinoma confers cancer stem cell⁃like behaviors contrib⁃
                   pendent stabilization of MDM4 in hepatocellular carcino⁃  uting to disease progression[J]. Cancer Res,2015,75
                   ma[J]. Hepatology,2014,9(5):1886-1899            (22):4985-4997
             [7] LIU Y,HE K,HU Y,et al. YAP modulates TGF⁃β1⁃in⁃  [19] LAMAR J M,STERN P,LIU H,et al. The Hippo pathway
                   duced simultaneous apoptosis and EMT through upregula⁃  target,YAP,promotes metastasis through its TEAD⁃inter⁃
                   tion of the EGF receptor[J]. Sci Rep,2017,7:45523  action domain[J]. Proc Nat Acad Sci USA,2012,109
             [8] ZHANG S,ZHOU D. Role of the transcriptional coactiva⁃  (37):E2441- E2450
                   tors YAP/TAZ in liver cancer[J]. Curr Opin Cell Biol,  [20] NGO M T,PENG S W,KUO Y C,et al. A Yes⁃associated
                   2019,61:64-71                                     protein(YAP)and insulin⁃like growth factor 1 receptor
             [9] ZHANG X,LI Y,MA Y,et al. Yes ⁃ associated protein  (IGF ⁃ 1R)signaling loop is involved in sorafenib resis⁃
                  (YAP)binds to HIF⁃1α and sustains HIF⁃1α protein sta⁃  tance in hepatocellular carcinoma[J]. Cancers(Basel),
                   bility to promote hepatocellular carcinoma cell glycolysis  2021,13(15):3812
                   under hypoxic stress[J]. J Exp Clin Cancer Res,2018,37  [21] ZHANG H,VON GISE A,LIU Q,et al. Yap1 is required
                  (1):216                                            for endothelial to mesenchymal transition of the atrioven⁃
             [10] 马天云,罗      超,刘龙飞,等. HMGCS1表达对食管鳞癌                  tricular cushion[J]. J Biol Chem,2014,289(27):18681-
                   细胞转移能力及食管鳞癌患者预后的影响[J]. 南京医                        18692
                   科大学学报(自然科学版),2022,42(10):1357-1363           [22] PANCIERA T,AZZOLIN L,CORDENONSI M,et al.
             [11] 周   玮. MOB2通过Hippo通路调控肝癌细胞迁移和侵                     Mechanobiology of YAP and TAZ in physiology and dis⁃
                   袭及芹菜素干预的机制研究[D]. 扬州:扬州大学,                         ease[J]. Nat Rev Mol Cell Biol,2017,18(12):758-770

                   2021                                         [23] SKENE P J,STEVEN H. An efficient targeted nuclease
             [12] LEE S,FRANCOEUR A M,LIU S,et al. Tissue⁃specific   strategy for high⁃resolution mapping of DNA binding sites
                   expression in mammalian brain,heart,and muscle of S1,  [J]. eLife,2017,6:e21856
                   a member of the elongation factor⁃1 alpha gene family[J].              [收稿日期] 2022-07-26
                   J Biol Chem,1992,267(33):24064-24068                                        (责任编辑:蒋      莉)
   17   18   19   20   21   22   23   24   25   26   27