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YAP 和 EEF1A2 参与肝癌转移调控的理解,有可能 [13] YANG S,LU M,CHEN Y,et al. Overexpression of eu⁃
为抗肝癌转移提供新的治疗靶标。 karyotic elongation factor 1 alpha ⁃ 2 is associated with
poorer prognosis in patients with gastric cancer[J]. J Can⁃
[参考文献]
cer Res Clin Oncol,2015,141(7):1265-1275
[1] LLOVET J M,KELLEY R K,VILLANUEVA A,et al. He⁃ [14] SCAGGIANTE B,DAPAS B,BONIN S,et al. Dissecting
patocellular carcinoma[J]. Nat Rev Dis Primers,2021,7 the expression of EEF1A1/2 genes in human prostate can⁃
(1):6 cer cells:the potential of EEF1A2 as a hallmark for pros⁃
[2] ZANCONATO F,CORDENONSI M,PICCOLO S. YAP/ tate transformation and progression[J]. Br J Cancer,
TAZ at the roots of cancer[J]. Cancer Cell,2016,29(6): 2012,106(1):166-173
783-803 [15] HU D M,XU C,ZHU Q. eEF1A2 protein expression cor⁃
[3] GIUDICI F,PETRACCI E,NANNI O,et al. Elevated lev⁃ relates with lymph node metastasis and decreased surviv⁃
els of eEF1A2 protein expression in triple negative breast al in pancreatic ductal adenocarcinoma[J]. Hepato gas⁃
cancer relate with poor prognosis[J]. PLoS One,2019,14 troenterology,2013,60(124):870-875
(6):e0218030 [16] WANG S,LI H,WANG G,et al. Yes⁃associated protein
[4] AMIRI A,NOEI F,JEGANATHAN S,et al. eEF1A2 acti⁃ (YAP)expression is involved in epithelial⁃mesenchymal
vates Akt and stimulates Akt ⁃ dependent actin remodel⁃ transition in hepatocellular carcinoma[J]. Clin Transl On⁃
ing,invasion and migration[J]. Oncogene,2007,26 col,2016,18(2):172-177
(21):3027-3040 [17] HUANG Z,ZHOU J K,WANG K,et al. PDLIM1 inhibits
[5] QIU F N,HUANG Y,CHEN D Y,et al. Eukaryotic elon⁃ tumor metastasis through activating Hippo signaling in he⁃
gation factor⁃1α 2 knockdown inhibits hepatocarcinogene⁃ patocellular carcinoma[J]. Hepatology,2020,71(5):
sis by suppressing PI3K/Akt/NF⁃κB signaling[J]. World 1643-1659
J Gastroenterol,2016,22(16):4226-4237 [18] HAYASHI H,HIGASHI T,YOKOYAMA N,et al. An im⁃
[6] PELLEGRINO R,CALVISI D F,NEUMANN O,et al. balance in TAZ and YAP expression in hepatocellular
EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR⁃de⁃ carcinoma confers cancer stem cell⁃like behaviors contrib⁃
pendent stabilization of MDM4 in hepatocellular carcino⁃ uting to disease progression[J]. Cancer Res,2015,75
ma[J]. Hepatology,2014,9(5):1886-1899 (22):4985-4997
[7] LIU Y,HE K,HU Y,et al. YAP modulates TGF⁃β1⁃in⁃ [19] LAMAR J M,STERN P,LIU H,et al. The Hippo pathway
duced simultaneous apoptosis and EMT through upregula⁃ target,YAP,promotes metastasis through its TEAD⁃inter⁃
tion of the EGF receptor[J]. Sci Rep,2017,7:45523 action domain[J]. Proc Nat Acad Sci USA,2012,109
[8] ZHANG S,ZHOU D. Role of the transcriptional coactiva⁃ (37):E2441- E2450
tors YAP/TAZ in liver cancer[J]. Curr Opin Cell Biol, [20] NGO M T,PENG S W,KUO Y C,et al. A Yes⁃associated
2019,61:64-71 protein(YAP)and insulin⁃like growth factor 1 receptor
[9] ZHANG X,LI Y,MA Y,et al. Yes ⁃ associated protein (IGF ⁃ 1R)signaling loop is involved in sorafenib resis⁃
(YAP)binds to HIF⁃1α and sustains HIF⁃1α protein sta⁃ tance in hepatocellular carcinoma[J]. Cancers(Basel),
bility to promote hepatocellular carcinoma cell glycolysis 2021,13(15):3812
under hypoxic stress[J]. J Exp Clin Cancer Res,2018,37 [21] ZHANG H,VON GISE A,LIU Q,et al. Yap1 is required
(1):216 for endothelial to mesenchymal transition of the atrioven⁃
[10] 马天云,罗 超,刘龙飞,等. HMGCS1表达对食管鳞癌 tricular cushion[J]. J Biol Chem,2014,289(27):18681-
细胞转移能力及食管鳞癌患者预后的影响[J]. 南京医 18692
科大学学报(自然科学版),2022,42(10):1357-1363 [22] PANCIERA T,AZZOLIN L,CORDENONSI M,et al.
[11] 周 玮. MOB2通过Hippo通路调控肝癌细胞迁移和侵 Mechanobiology of YAP and TAZ in physiology and dis⁃
袭及芹菜素干预的机制研究[D]. 扬州:扬州大学, ease[J]. Nat Rev Mol Cell Biol,2017,18(12):758-770
2021 [23] SKENE P J,STEVEN H. An efficient targeted nuclease
[12] LEE S,FRANCOEUR A M,LIU S,et al. Tissue⁃specific strategy for high⁃resolution mapping of DNA binding sites
expression in mammalian brain,heart,and muscle of S1, [J]. eLife,2017,6:e21856
a member of the elongation factor⁃1 alpha gene family[J]. [收稿日期] 2022-07-26
J Biol Chem,1992,267(33):24064-24068 (责任编辑:蒋 莉)