Page 93 - 南京医科大学学报自然科学版

第43卷第4期 南京医科大学学报（自然科学版）
2023年4月 Journal of Nanjing Medical University（Natural Sciences） ·531 ·

·临床研究·

肌腱蛋白C对支气管肺发育不良诊断价值的前瞻性研究

胡晶晶，郑亚斐，朱海艳，包天平，程怀平，田兆方 *
南京医科大学附属淮安第一医院新生儿科，淮安市小儿呼吸诊疗重点实验室，江苏 淮安 223300

［摘 要］ 目的：探讨血清肌腱蛋白 C（tenascin C，TNC）对早产儿支气管肺发育不良（bronchopulmonary dysplasia，BPD）的诊
断价值。方法：选择 2018—2020 年南京医科大学附属淮安第一医院新生儿科 79 例极低出生体重早产儿，根据美国国家
儿童健康和人类发育研究所诊断标准分为非 BPD 组（n=48）和 BPD 组（n=31）。ELISA 法检测血清 TNC 水平；多因素 Logistic
回归分析 BPD 发生的独立危险因素；Kendall相关分析血清TNC水平与BPD严重程度的相关性；绘制TNC诊断BPD的受试者
工作特征（receiver operating characteristic，ROC）曲线。结果：①早产儿血清TNC水平在非BPD组与BPD组间差异有统计学意
义［（95.03 ± 19.73）ng/mL vs.（125.40 ± 19.34）ng/mL，P < 0.001］，不同级别BPD组间差异有统计学意义（P < 0.001）；②早产儿发
生BPD的独立危险因素包括出生体重、高浓度氧吸入时间及血清TNC水平（P < 0.05）；③血清TNC水平与BPD严重程度呈正相关
（r =0.617，P < 0.001）；④血清TNC诊断BPD的ROC曲线下面积为0.881（P < 0.001），灵敏度为96.8%，特异度为66.7%。结论：血
清TNC水平在BPD中增高，诊断的灵敏度及特异度较高，可作为判断早产儿BPD的标志物之一。
［关键词］ 肌腱蛋白C；早产儿；极低出生体重儿；支气管肺发育不良；标志物
［中图分类号］ R725.6 ［文献标志码］ A ［文章编号］ 1007⁃4368（2023）04⁃531⁃06
doi：10.7655/NYDXBNS20230412

Prospective study on the diagnostic value of tenascin C in bronchopulmonary dysplasia

HU Jingjing，ZHENG Yafei，ZHU Haiyan，BAO Tianping，CHENG Huaiping，TIAN Zhaofang *
Department of Neonatology，the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University，Huai’an
Key Laboratory of Diagnosis and Treatment of Pediatric Respiratory Diseases，Huai’an 223300，China

［Abstract］ Objective：To explore the diagnostic value of serum tenascin C（TNC）in bronchopulmonary dysplasia（BPD）of the
premature infants. Methods：Seventy⁃nine very low birth weight premature infants were enrolled from Department of Neonatology，the
Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University from 2018 to 2020. According to the 2018 NICHD diagnostic
criteria，they were divided into the non⁃BPD group（n=48）and the BPD group（n=31）. ELISA was used to detect serum TNC level；
Multivariate logistic regression was conducted to analyze the independent risk factors of BPD；The correlation between serum TNC
level and the severity of BPD was analyzed by Kendall correlation；Receiver operating characteristic（ROC）curve of TNC for diagnosis
of BPD was made. Results：①The serum TNC level of preterm infants was statistically different between the non⁃BPD group and the
BPD group［（95.03±19.73）ng/mL vs.（125.40±19.34）ng/mL，P < 0.001］，and there was statistical difference between different levels
of BPD groups（P < 0.001）. ②The independent risk factors for BPD in premature infants included birth weigh，high concentration
oxygen inhalation time and serum TNC level（P < 0.05）. ③Serum TNC level was positively correlated with the severity of BPD（r =0.617，
P < 0.001）. ④The area under the curve for the diagnosis of BPD by serum TNC was 0.881（P < 0.001），the sensitivity was 96.8%，
and the specificity was 66.7%. Conclusion：Serum TNC level increases in BPD，and the diagnostic sensitivity and specificity is high，
which can be used as one of the biomarkers for diagnosis of premature BPD.
［Key words］ tenascin C；premature infants；very low birth weight infant；bronchopulmonary dysplasia；biomarker
［J Nanjing Med Univ，2023，43（04）：531⁃535，562］

［基金项目］ 江苏省卫健委妇幼健康科研项目重点课题（F201909）；江苏省卫健委医学科研重点项目（ZDB2020005）
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通信作者（Corresponding author），E⁃mail：lyh0729@163.com