Page 116 - 南京医科大学学报自然科学版

南京医科大学学报（自然科学版） 第43卷第8期
·1150 · Journal of Nanjing Medical University（Natural Sciences） 2023年8月

·临床研究·

头孢他啶阿维巴坦治疗碳青霉烯类耐药铜绿假单胞菌感染的

疗效与安全性分析

张梦怡 ，冯孟文 ，张 倩 ，朱冬梅 ，傅源源 ，黄 敏 ，周 静 1*
1
1
1
2
1
1
南京医科大学第一附属医院老年ICU，药学部，江苏 南京 210029
1 2
［摘 要］ 目的：在碳青霉烯类耐药铜绿假单胞菌感染患者中，比较头孢他啶阿维巴坦组与以多粘菌素B为基础的联合治疗
的疗效和安全性。方法：回顾性分析2019年6月—2022年1月南京医科大学第一附属医院各ICU内碳青霉烯类耐药铜绿假单
胞菌感染患者，依据治疗方式分为头孢他啶阿维巴坦组和多粘菌素B联合组，收集患者临床资料，包括性别、年龄、诊断、住院
时间等基本信息，比较疗效指标，包括细菌清除率、28 d病死率等，以及肝肾功能不全等不良反应的发生率。结果：共纳入55
例，其中头孢他啶阿维巴坦组25例，多粘菌素B联合组30例，两组之间基本指标、细菌清除率、28 d病死率、不良反应差异均无
统计学意义，头孢他啶阿维巴坦组住院时间长于多粘菌素B联合组［49.0（34.0，78.0）vs. 26.0（15.8，40.5），P=0.001），在抗生素联
合应用方面较多粘菌素B联合组少。结论：与多粘菌素B相比，头孢他啶阿维巴坦在临床治愈、细菌清除率方面效果相似，不
良反应方面无统计学差异，增加了临床用药的选择，有助于减轻公共卫生事业压力。
［关键词］ 碳青霉烯类耐药铜绿假单胞菌；头孢他啶阿维巴坦；多粘菌素B；疗效；安全性

［中图分类号］ R515 ［文献标志码］ A ［文章编号］ 1007⁃4368（2023）08⁃1150⁃06
doi：10.7655/NYDXBNS20230817

The efficacy and safety of ceftazidime avibactam versus polymyxin B for patients with
carbapenem⁃resistant Pseudomonas aeruginosa infection
1 1 1 1 2 1 1*
ZHANG Mengyi ，FENG Mengwen ，ZHANG Qian ，ZHU Dongmei ，FU Yuanyuan ，HUANG Min ，ZHOU Jing
1 Department of Geriatric ICU，Department of Pharmacy，the First Affiliated Hospital of Nanjing Medical University，
2
Nanjing 210029，China

［Abstract］ Objective：To evaluate the efficacy and safety of ceftazidime avibactam compared with polymyxin based combination
therapy in patients with carbapenem resistant Pseudomonas aeruginosa infection. Methods：Retrospective analysis was carried out on
the patients infected with carbapenem resistant Pseudomonas aeruginosa in the ICU of the First Affiliated Hospital of Nanjing Medical
University between June 2019 and January 2022. They were divided into ceftazidime avibactam group and polymyxin B group. The
clinical data of patients were collected，including basic information，such as gender，age，diagnosis，and length of stay. The comparative
efficacy indicators included bacterial clearance rate，28⁃day mortality rate and the incidence of adverse reactions，such as liver and
kidney dysfunction. Results：A total of 55 patients were included，including 25 patients in the ceftazidime avibactam group and 30
patients in the polymyxin B group. There was no statistically significant difference in basic indicators，bacterial clearance，28⁃day
mortality，and adverse reactions between the two groups. The length of hospital stay in the ceftazidime avibactam group was longer than
that in the polymyxin B group［49.0（34.0，78.0）vs. 26.0（15.8，40.5），P=0.001］，and ceftazidime avibactam group had fewer antibiotic
combinations than polymyxin B group. Conclusion：Compared with polymyxin B，ceftazidime averbactam has similar effects in clinical
cure and bacterial clearance，and there is no statistical difference in adverse reactions. Ceftazidime averbaltam increases the choice of
clinical drugs and helps to reduce the pressure on public health.
［Key words］ carbapenem⁃resistant pseudomonas aeruginosa；ceftazidime avibactam；polymyxin B；effect；security
［J Nanjing Med Univ，2023，43（08）：1150⁃1155］

［基金项目］ 江苏省卫生健康委科研课题（BJ20019）
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通信作者（Corresponding author），E⁃mail：zhoujing1364@jsph.org.cn