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· 8 · 南 京 医 科 大 学 学 报 2024年1月
A B
Cluster Control COPD
Subtype Subtype
KEGG_LINOLEIC_ACID_METABOLISM 2 Control 1.00
COPD 0.75
KEGG_RETINOL_METABOLISM 0.50
KEGG_DRUG_METABOLISM_CYTOCHROME_P450 1 Immune infiltration 0.25
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 0.00
0
KEGG_VIRAL_MYOCARDITIS
KEGG_OOCYTE_MEIOSIS
-1
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION KEGG_APOPTOSIS
KEGG_ENDOCYTOSIS
-2
KEGG_ADHERENS_JUNCTION
KEGG_LONG_TERM_POTENTIATION PRIMARY_IMMUNODEFICIENCY
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION CHEMOKINE_RECEPTOR_INTERACTION KEGG_CHEMOKINE_SIGNALING_PATHWAY
KEGG_GNRH_SIGNALING_PATHWAY KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS
KEGG_NOTCH_SIGNALING_PATHWAY KEGG_COMPLEMENT_AND_COAGULATION_CASGADES KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION
KEGG_AXON_GUIDANCE KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY
KEGG_CARDIAC_MUSCLE_CONTRACTION KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC
KEGG_DILATED_CARDIOMYOPATHY
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM
KEGG_FOCAL_ADHESION
KEGG_ECM_RECEPTOR_INTERACTION
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON
KEGG_LONG_TERM_DEPRESSION
KEGG_P53_SIGNALING_PATHWAY
KEGG_OLFACTORY_TRANSDUCTION
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES C
KEGG_GLYCEROLIPID_METABOLISM
KEGG_PPAR_SIGNALING_PATHWAY
KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS
KEGG_BASAL_TRANSCRIPTION_FACTORS Correlation
**
A2M2M
A ** * * ** ** **
**
**
**
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.0
-0.1
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION -0.2
KEGG_JAK_STAT_SIGNALING_PATHWAY -0.3
-0.4
KEGG_APOPTOSIS -0.5
ANTIGEN_PROCESSING_AND_PRESENTATION B_CELL_RECEPTOR_SOGMALING_PATNWAY
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY APOPTOSIS
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES
KEGG_FOLATE_BIOSYNTHESIS
KEGG_O_GLYCAN_BIOSYNTHESIS CHEMOKINE_OGMALING_PATNWAY PRIMARY_IMMUNODEFICIENCY
KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS T_CELL_RECEPTOR_SIGNALING_PATHWAY
KEGG_SPHINGOLIPID_METABOLISM COMPLEMENT_AND_COAGULATION_CASCADES CYTOKINE_CYTOKINE_RECEPTOR_NTERACTION
KEGG_GALACTOSE_METABOLISM NATURAI_KILLER_CELL_MEOIATEO_CYTOTOXICITY
A:Heat map of differential pathways between normal and COPD samples. B:Violin plot of the distribution of immune⁃related pathways in COPD
patients. C:Association of A2M with immune⁃related pathways in COPD. Compared with the control group,P < 0.05,P < 0.01。
**
*
图3 COPD相关的免疫信号通路分析
Figure 3 Analysis of immune signaling pathways associated with COPD
促炎反应,然而,在本研究的免疫浸润分析中未观 子都与加重肺气肿发展的肺实质组织损伤有关 [20] 。
察到 M1 巨噬细胞在对照组和 COPD 组之间存在差 然而,本研究观察到的 CD8 T 减少与以前的研究不
+
异。M2巨噬细胞主要参与抗炎反应,在COPD组中 一致。COPD 患者肺部产生γ干扰素的CD8 和CD4 +
+
显著减少,表明其功能可能在 COPD 中受损。研究 淋巴细胞数量增加 [21] 。与正常对照组和非吸烟
还发现 COPD 患者肺组织中 CD8 T 细胞的表达减 者相比,COPD 患者的 CD8 T 细胞亚群频率显著
+
+
少。CD8 T细胞主要分泌IL⁃4和IL⁃5,这两种细胞因 增加 [22] 。这可能由于生物信息学方法和流式细胞
+