Page 14 - 南京医科大学学报自然科学版

第44卷第1期
· 8 · 南 京 医 科 大 学 学 报 2024年1月

A B
Cluster Control COPD
Subtype Subtype
KEGG_LINOLEIC_ACID_METABOLISM 2 Control 1.00
COPD 0.75
KEGG_RETINOL_METABOLISM 0.50
KEGG_DRUG_METABOLISM_CYTOCHROME_P450 1 Immune infiltration 0.25
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 0.00
0
KEGG_VIRAL_MYOCARDITIS
KEGG_OOCYTE_MEIOSIS
-1
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION KEGG_APOPTOSIS
KEGG_ENDOCYTOSIS
-2
KEGG_ADHERENS_JUNCTION
KEGG_LONG_TERM_POTENTIATION PRIMARY_IMMUNODEFICIENCY
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION CHEMOKINE_RECEPTOR_INTERACTION KEGG_CHEMOKINE_SIGNALING_PATHWAY
KEGG_GNRH_SIGNALING_PATHWAY KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS
KEGG_NOTCH_SIGNALING_PATHWAY KEGG_COMPLEMENT_AND_COAGULATION_CASGADES KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION
KEGG_AXON_GUIDANCE KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY
KEGG_CARDIAC_MUSCLE_CONTRACTION KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC
KEGG_DILATED_CARDIOMYOPATHY
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM
KEGG_FOCAL_ADHESION
KEGG_ECM_RECEPTOR_INTERACTION
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON
KEGG_LONG_TERM_DEPRESSION
KEGG_P53_SIGNALING_PATHWAY
KEGG_OLFACTORY_TRANSDUCTION
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES C
KEGG_GLYCEROLIPID_METABOLISM
KEGG_PPAR_SIGNALING_PATHWAY
KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS
KEGG_BASAL_TRANSCRIPTION_FACTORS Correlation
**
A2M2M
A ** * * ** ** **
**
**
**
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.0
-0.1
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION -0.2
KEGG_JAK_STAT_SIGNALING_PATHWAY -0.3
-0.4
KEGG_APOPTOSIS -0.5
ANTIGEN_PROCESSING_AND_PRESENTATION B_CELL_RECEPTOR_SOGMALING_PATNWAY
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY APOPTOSIS
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES
KEGG_FOLATE_BIOSYNTHESIS
KEGG_O_GLYCAN_BIOSYNTHESIS CHEMOKINE_OGMALING_PATNWAY PRIMARY_IMMUNODEFICIENCY
KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS T_CELL_RECEPTOR_SIGNALING_PATHWAY
KEGG_SPHINGOLIPID_METABOLISM COMPLEMENT_AND_COAGULATION_CASCADES CYTOKINE_CYTOKINE_RECEPTOR_NTERACTION
KEGG_GALACTOSE_METABOLISM NATURAI_KILLER_CELL_MEOIATEO_CYTOTOXICITY

A：Heat map of differential pathways between normal and COPD samples. B：Violin plot of the distribution of immune⁃related pathways in COPD
patients. C：Association of A2M with immune⁃related pathways in COPD. Compared with the control group，P < 0.05，P < 0.01。
**
*
图3 COPD相关的免疫信号通路分析
Figure 3 Analysis of immune signaling pathways associated with COPD
促炎反应，然而，在本研究的免疫浸润分析中未观 子都与加重肺气肿发展的肺实质组织损伤有关 ［20］ 。
察到 M1 巨噬细胞在对照组和 COPD 组之间存在差 然而，本研究观察到的 CD8 T 减少与以前的研究不
+
异。M2巨噬细胞主要参与抗炎反应，在COPD组中 一致。COPD 患者肺部产生γ干扰素的CD8 和CD4 +
+
显著减少，表明其功能可能在 COPD 中受损。研究 淋巴细胞数量增加 ［21］ 。与正常对照组和非吸烟
还发现 COPD 患者肺组织中 CD8 T 细胞的表达减 者相比，COPD 患者的 CD8 T 细胞亚群频率显著
+
+
少。CD8 T细胞主要分泌IL⁃4和IL⁃5，这两种细胞因 增加 ［22］ 。这可能由于生物信息学方法和流式细胞
+