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第44卷第5期 王诗铫,黄志航,蒋 腾. TREM2在阿尔茨海默病中的研究进展[J].
2024年5月 南京医科大学学报(自然科学版),2024,44(5):698-704,731 ·703 ·
Aging,2020,86:201 ture,function,therapeutic prospects,and activation chal⁃
[21]FILIPELLO F,YOU S F,MIRFAKHAR F S,et al. De⁃ lenges[J]. Mol Cell Neurosci,2024,128:103917
fects in lysosomal function and lipid metabolism in hu⁃ [35]BROWN G C,ST GEORGE ⁃ HYSLOP P. Does soluble
man microglia harboring a TREM2 loss of function muta⁃ TREM2 protect against Alzheimer’s disease?[J]. Front
tion[J]. Acta Neuropathol,2023,145(6):749-772 Aging Neurosci,2022,13:834697
[22]LI X X,ZHANG F. Targeting TREM2 for Parkinson’s dis⁃ [36]KOBER D L,STUCHELL ⁃ BRERETON M D,KLUEN⁃
ease:where to go?[J]. Front Immunol,2021,12:795036 DER C E,et al. Functional insights from biophysical
[23]JIAO B,LIU X Y,TANG B S,et al. Investigation of study of TREM2 interactions with apoE and Aβ1⁃42 [J/OL].
TREM2,PLD3,and UNC5C variants in patients with Al⁃ Alzheimers Dement,2020[2024⁃01⁃05]. DOI:10.1002/
zheimer’s disease from mainland China[J]. Neurobiol alz.12194
Aging,2014,35(10):2422.e9-2422422.e11 [37]SERRANO⁃POZO A,DAS S,HYMAN B T. APOE and Al⁃
[24]SIMS R,VAN DER LEE S J,NAJ A C,et al. Rare coding zheimer’s disease:advances in genetics,pathophysiology,
variants in PLCG2,ABI3,and TREM2 implicate microglial and therapeutic approaches[J]. Lancet Neurol,2021,20
⁃ mediated innate immunity in Alzheimer’s disease[J]. (1):68-80
Nat Genet,2017,49(9):1373-1384 [38]WANG S T,COLONNA M. The microglial immunorecep⁃
[25]JIN S C,BENITEZ B A,KARCH C M,et al. Coding vari⁃ tor tyrosine⁃based motif⁃Syk signaling pathway is a promis⁃
ants in TREM2 increase risk for Alzheimer’s disease[J]. ing target of immunotherapy for Alzheimer’s disease[J].
Hum Mol Genet,2014,23(21):5838-5846 Clin Transl Med,2023,13(2):e1200
[26]SONG W,HOOLI B,MULLIN K,et al. Alzheimer’s dis⁃ [39]ZHANG T M,MA S H,LV J K,et al. The emerging role of
ease⁃associated TREM2 variants exhibit either decreased exosomes in Alzheimer’s disease[J]. Ageing Res Rev,
or increased ligand⁃dependent activation[J]. Alzheimers 2021,68:101321
Dement,2017,13(4):381-387 [40]CHATILA Z K,BRADSHAW E M. Alzheimer’s disease
[27]OLIVE C,IBANEZ L,FARIAS F H G,et al. Examination genetics:a dampened microglial response?[J]. Neurosci⁃
of the effect of rare variants in TREM2,ABI3,and PLCG2 entist,2023,29(2):245-263
in LOAD through multiple phenotypes[J]. J Alzheimers [41]LEFTEROV I,FITZ N F,LU Y,et al. APOEε4 and risk
Dis,2020,77(4):1469-1482 of Alzheimer’s disease⁃time to move forward[J]. Front
[28]ZHOU S L,TAN C C,HOU X H,et al. TREM2 variants Neurosci,2023,17:1195724
and neurodegenerative diseases:a systematic review and [42]姜敏艳,汪 旭,郭锡汉. 小胶质细胞TREM2调控阿尔
meta⁃analysis[J]. J Alzheimers Dis,2019,68(3):1171- 茨海默病发生的机制研究进展[J]. 生命科学,2023,35
1184 (11):1484-1497
[29]ZHONG L,XU Y,ZHUO R G,et al. Soluble TREM2 ame⁃ [43]OBST J,HALL⁃ROBERTS H L,SMITH T B,et al. PLCγ2
liorates pathological phenotypes by modulating microglial regulates TREM2 signalling and integrin⁃mediated ad⁃
functions in an Alzheimer’s disease model[J]. Nat Com⁃ hesion and migration of human iPSC ⁃ derived macro⁃
mun,2019,10(1):1365 phages[J]. Sci Rep,2021,11(1):19842
[30]COLONNA M. The biology of TREM receptors[J]. Nat [44]SCHMITZ E A,TAKAHASHI H,KARAKAS E. Structural
Rev Immunol,2023,23(9):580-594 basis for activation and gating of IP 3 receptors[J]. Nat
[31]SUN H F,FENG J G,TANG L L. Function of TREM1 and Commun,2022,13(1):1408
TREM2 in liver⁃related diseases[J]. Cells,2020,9(12): [45]AKHTER R,SHAO Y,FORMICA S,et al. TREM2 alters
2626 the phagocytic,apoptotic and inflammatory response to
[32]JIANG T,YU J T,ZHU X C,et al. Triggering receptor ex⁃ Aβ42 in HMC3 cells[J]. Mol Immunol,2021,131:171-
pressed on myeloid cells 2 knockdown exacerbates aging⁃ 179
related neuroinflammation and cognitive deficiency in se⁃ [46]VANRYZIN J W. Phagocytic microglia in development:
nescence⁃accelerated mouse prone 8 mice[J]. Neurobiol are they what they eat?[J]. Brain Behav Immun Health,
Aging,2014,35(6):1243-1251 2021,18:100373
[33]FORABOSCO P,RAMASAMY A,TRABZUNI D,et al. [47]GUO S R,WANG H,YIN Y F. Microglia polarization
Insights into TREM2 biology by network analysis of hu⁃ from M1 to M2 in neurodegenerative diseases[J]. Front
man brain gene expression data[J]. Neurobiol Aging, Aging Neurosci,2022,14:815347
2013,34(12):2699-2714 [48]CAI W J,WU T,CHEN N. The amyloid⁃beta clearance:
[34]ZGORZYNSKA E. TREM2 in Alzheimer’s disease:struc⁃ from molecular targets to glial and neural cells[J]. Bio⁃