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AUD C,et al. Physical exercise in the prevention and [16]OAKLEY H,COLE S L,LOGAN S,et al. Intraneuronal
treatment of Alzheimer’s disease[J]. J Sport Health Sci, beta ⁃ amyloid aggregates,neurodegeneration,and neuron
2020,9(5):394-404 loss in transgenic mice with five familial Alzheimer’s
[6] ORNISH D,MADISON C,KIVIPELTO M,et al. Effects disease mutations:potential factors in amyloid plaque
of intensive lifestyle changes on the progression of mild formation[J]. J Neurosci,2006,26(40):10129-10140
cognitive impairment or early dementia due to Alzheimer’s [17]LOCCI A,ORELLANA H,RODRIGUEZ G,et al. Com⁃
disease:a randomized,controlled clinical trial[J]. Al⁃ parison of memory,affective behavior,and neuropatholo⁃
zheimers Res Ther,2024,16(1):122 gy in APP NLGF knock⁃in mice to 5×FAD and APP/PS1
[7] ISHIWARI K,KING C P,MARTIN C D,et al. Environ⁃ mice[J]. Behav Brain Res,2021,404:113192
mental enrichment promotes adaptive responding during [18]KOSEL F,TORRES MUNOZ P,YANG J R,et al. Age⁃
tests of behavioral regulation in male heterogeneous stock related changes in social behaviours in the 5×FAD mouse
rats[J]. Sci Rep,2024,14(1):4182 model of Alzheimer’s disease[J]. Behav Brain Res,
[8] CAO M,HU P P,ZHANG Y L,et al. Enriched physical 2019,362:160-172
environment reverses spatial cognitive impairment of so⁃ [19]MENON V,D′ESPOSITO M. The role of PFC networks in
cially isolated APPswe/PS1dE9 transgenic mice before cognitive control and executive function[J]. Neuropsycho⁃
amyloidosis onset[J]. CNS Neurosci Ther,2018,24(3): pharmacology,2022,47(1):90-103
202-211 [20]KLUNE C B,JIN B,DENARDO L A. Linking mPFC
[9] NAKANO M,KUBOTA K,HASHIZUME S,et al. An en⁃ circuit maturation to the developmental regulation of
riched environment prevents cognitive impairment in an emotional memory and cognitive flexibility[J]. Elife,
Alzheimer’s disease model by enhancing the secretion of 2021,10:e64567
exosomal microRNA ⁃ 146a from the choroid plexus[J]. [21]YANG Y,QIU L. Research progress on the pathogenesis,
Brain Behav Immun Health,2020,9:100149 diagnosis,and drug therapy of Alzheimer’s disease[J].
[10]LI M,WANG S Z,ZHAO Y B,et al. Rac1 in parvalbumin Brain Sci. 2024,14(6):590
neurons of the medial prefrontal cortex governs rapid [22]ZHANG X X,TIAN Y,WANG Z T,et al. The epidemiology
forgetting of social memory[J]. Mol Psychiatry,2025,30 of Alzheimer’s disease modifiable risk factors and pre⁃
(8):3740-3751 vention[J]. J Prev Alzheimers Dis,2021,8(3):313-321
[11]PENG J Z,TANG Q,LI Y L,et al. Neuromorphic devia⁃ [23]TAI L W,YEUNG S C,CHEUNG C W. Enriched environ⁃
tions associated with transcriptomic expression and specific ment and effects on neuropathic pain:experimental find⁃
cell type in Alzheimer’s disease[J]. Sci Rep,2025,15(1): ings and mechanisms[J]. Pain Pract,2018,18(8):1068-
7460 1082
[12]MISRANI A,TABASSUM S,HUO Q W,et al. Mitochon⁃ [24]LAMBERT K,HYER M,BARDI M,et al. Natural ⁃ en⁃
drial deficits with neural and social damage in early⁃stage riched environments lead to enhanced environmental en⁃
Alzheimer’s disease model mice[J]. Front Aging Neuro⁃ gagement and altered neurobiological resilience[J]. Neu⁃
sci,2021,13:748388 roscience,2016,330:386-394
[13]NACHTIGALL E G,DE FREITAS J D R,MARCONDES [25]PARAMBATH S K,KRISHNA N,KRISHNAMURTHY R
L A,et al. Memory persistence induced by environmental G. Environmental enrichment:a neurostimulatory ap⁃
enrichment is dependent on different brain structures[J]. proach to aging and ischemic stroke recovery and rehabili⁃
Physiol Behav,2023,272:114375 tation[J]. Biogerontology,2025,26(3):92
[14]DARNA M,BECKMANN J S,GIPSON C D,et al. Effect [26]BALTHAZAR J,SCHÖWE N M,CIPOLLI G C,et al.
of environmental enrichment on dopamine and serotonin Enriched environment significantly reduced senile
transporters and glutamate neurotransmission in medial plaques in a transgenic mice model of Alzheimer’s dis⁃
prefrontal and orbitofrontal cortex[J]. Brain Res,2015, ease,improving memory[J]. Front Aging Neurosci,2018,
1599:115-125 10:288
[15]KEMPERMANN G,LOPES J B,ZOCHER S,et al. The in⁃ [27]MATE V,SMOLEK T,KAZMEROVA Z V,et al. En⁃
dividuality paradigm:automated longitudinal activity riched environment ameliorates propagation of tau pathol⁃
tracking of large cohorts of genetically identical mice in ogy and improves cognition in rat model of tauopathy[J].
an enriched environment[J]. Neurobiol Dis,2022,175: Front Aging Neurosci,2022,14:935973
105916 [28]ZHANG X Q,WEI X J,MEI Y F,et al. Modulating adult

