Page 85 - 南京医科大学自然版
P. 85
第45卷第11期 林俊杰,孙君健,王 璐,等. IFN⁃γ通过抑制SRC/Areg信号轴减轻克罗恩病肠纤维化[J].
2025年11月 南京医科大学学报(自然科学版),2025,45(11):1608-1615,1625 ·1615 ·
eum lesions[J]. Journal of Nanjing Medical University al. A global consensus on the definitions,diagnosis and
(Natural Sciences),2025,(4):544-550 management of fibrostenosing small bowel Crohn’s dis⁃
[6] SANTACROCE G,LENTI M V,DI SABATINO A. Thera⁃ ease in clinical practice[J]. Nat Rev Gastroenterol Hepa⁃
peutic targeting of intestinal fibrosis in Crohn’s disease tol,2024,21(8):572-584
[J]. Cells,2022,11(3):429 [19]ZHAO S,DEJANOVIC D,YAO P,et al. Selective dele⁃
[7] LI J N,MAO R,KURADA S,et al. Pathogenesis of fibro⁃ tion of MyD88 signaling in α⁃SMA positive cells amelio⁃
stenosing Crohn’s disease[J]. Transl Res,2019,209:39- rates experimental intestinal fibrosis via post ⁃ transcrip⁃
54 tional regulation[J]. Mucosal Immunol,2020,13(4):
[8] RODA G,CHIEN NG S,KOTZE P G,et al. Crohn’s dis⁃ 665-678
ease[J]. Nat Rev Dis Primers,2020,6:22 [20]LIN S N,WANG J,MUKHERJEE P K,et al. Milk fat
[9] NAKATA T,LI C H,MAYASSI T,et al. Genetic vulnera⁃ globule⁃epidermal growth factor 8(MFGE8)prevents in⁃
bility to Crohn’s disease reveals a spatially resolved epi⁃ testinal fibrosis[J]. Gut,2024,73(7):1110-1123
thelial restitution program[J]. Sci Transl Med,2023,15 [21]DENG Z Q,FAN T,XIAO C,et al. TGF⁃β signaling in
(719):eadg5252 health,disease,and therapeutics[J]. Signal Transduct
[10]WU X M,LIN X X,TAN J Y,et al. Cellular and molecu⁃ Target Ther,2024,9(1):61
lar mechanisms of intestinal fibrosis[J]. Gut Liver,2023, [22]POH A R,ERNST M. Functional roles of SRC signaling
17(3):360-374 in pancreatic cancer:recent insights provide novel thera⁃
[11]林俊杰,王 舒,赵小静,等. 双调蛋白通过上调 LPA⁃ peutic opportunities[J]. Oncogene,2023,42(22):1786-
LPAR3 调控肠成纤维细胞活化促进克罗恩病肠纤维 1801
化[J]. 南京医科大学学报(自然科学版),2025,45(4): [23]KANSRA S,STOLL S W,JOHNSON J L,et al. Src family
498-508 kinase inhibitors block amphiregulin⁃mediated autocrine
LIN J J,WANG S,ZHAO X J,et al. Amphiregulin facili⁃ ErbB signaling in normal human keratinocytes[J]. Mol
tates intestinal fibrosis in Crohn’s disease by upregulat⁃ Pharmacol,2005,67(4):1145-1157
ing the LPA⁃LPAR3 expression thus regulating activation [24]ARPAIA N,GREEN J A,MOLTEDO B,et al. A distinct
of intestinal fibroblasts[J]. Journal of Nanjing Medical function of regulatory T cells in tissue protection[J]. Cell,
University(Natural Sciences). 2025,45(4):498-508 2015,162(5):1078-1089
[12]YANG W J,YU T M,CONG Y Z. Stromal cell regulation [25]TABEI Y,NAKAJIMA Y. IL⁃1β⁃activated PI3K/AKT and
of intestinal inflammatory fibrosis[J]. Cell Mol Gastroen⁃ MEK/ERK pathways coordinately promote induction of
terol Hepatol,2024,17(5):703-711 partial epithelial ⁃ mesenchymal transition[J]. Cell Com⁃
[13]GIESECK R L 3RD,WILSON M S,WYNN T A. Type 2 mun Signal,2024,22(1):392
immunity in tissue repair and fibrosis[J]. Nat Rev Immu⁃ [26]MORIMOTO Y,HIRAHARA K,KIUCHI M,et al. Amphi⁃
nol,2018,18(1):62-76 regulin ⁃ producing pathogenic memory T helper 2 cells
[14]WANG L,WANG S,LIN J J,et al. Treg and intestinal instruct eosinophils to secrete osteopontin and facilitate
myofibroblasts⁃derived amphiregulin induced by TGF⁃ β airway fibrosis[J]. Immunity,2018,49(1):134-150
mediates intestinal fibrosis in Crohn’s disease[J]. J [27]SAVAGE T M,FORTSON K T,DE LOS SANTOS⁃ALEX⁃
Transl Med,2025,23(1):452 IS K,et al. Amphiregulin from regulatory T cells promotes
[15]ZHAO X J,YANG W J,YU T M,et al. Th17 cell⁃derived liver fibrosis and insulin resistance in non⁃alcoholic ste⁃
amphiregulin promotes colitis⁃associated intestinal fibro⁃ atohepatitis[J]. Immunity,2024,57(2):303-318
sis through activation of mTOR and MEK in intestinal [28]TAKEUCHI S,TSUCHIYA A,IWASAWA T,et al. Small
myofibroblasts[J]. Gastroenterology,2023,164(1):89- extracellular vesicles derived from interferon⁃γ pre⁃condi⁃
102 tioned mesenchymal stromal cells effectively treat liver
[16]HU Z J,XU J,YIN J M,et al. Lower circulating interferon⁃ fibrosis[J]. NPJ Regen Med,2021,6(1):19
gamma is a risk factor for lung fibrosis in COVID⁃ 19 [29]YAMAMOTO T,TAKAGAWA S,KURODA M,et al.
patients[J]. Front Immunol,2020,11:585647 Effect of interferon⁃gamma on experimental scleroderma
[17]VU T N,CHEN X S,FODA H D,et al. Interferon⁃γ en⁃ induced by bleomycin[J]. Arch Dermatol Res,2000,292
hances the antifibrotic effects of pirfenidone by attenuat⁃ (7):362-365
ing IPF lung fibroblast activation and differentiation[J]. [30]QING Y L,STARK G R. Alternative activation of STAT1
Respir Res,2019,20(1):206 and STAT3 in response to interferon ⁃ gamma[J]. J Biol
[18]BETTENWORTH D,BAKER M E,FLETCHER J G,et (下转第1625页)

