Page 137 - 南京医科大学自然版

第45卷第12期 戴 丽，左祥林，胡 君. 鞘氨醇⁃1⁃磷酸信号通路在微循环障碍相关性心脏疾病中的作用及
2025年12月 治疗潜力［J］. 南京医科大学学报（自然科学版），2025，45（12）：1810-1822 ·1819 ·

［3］ SANTOS⁃GALLEGO C G，VAHL T P，GOLIASCH G，et phosphate and its receptors in vascular endothelial and
al. Sphingosine⁃1⁃phosphate receptor agonist fingolimod lymphatic barrier function［J］. J Biol Chem，2023，299
increases myocardial salvage and decreases adverse （6）：104775
postinfarction left ventricular remodeling in a porcine ［16］ZENG Y，ADAMSON R H，CURRY F E，et al. Sphingo⁃
model of ischemia/reperfusion［J］. Circulation，2016，133 sine⁃1⁃phosphate protects endothelial glycocalyx by inhib⁃
（10）：954-966 iting syndecan⁃1 shedding［J］. Am J Physiol Heart Circ
［4］ CECERE A，PERAZZOLO MARRA M，ZANATTA E，et Physiol，2014，306（3）：H363-H372
al. Coronary microvascular dysfunction in autoimmune ［17］BURG N，SWENDEMAN S，WORGALL S，et al. Sphingo⁃
rheumatic diseases：beyond coronary flow velocity reserve sine 1⁃phosphate receptor 1 signaling maintains endothelial
［J］. Front Cardiovasc Med，2024，11：1372703 cell barrier function and protects against immune complex⁃
［5］ LINDNER J R. Microvascular impairment after myocardi⁃ induced vascular injury［J］. Arthritis Rheumatol，2018，70
al infarction：it is not just about obstruction［J］. Circ Car⁃ （11）：1879-1889
diovasc Imaging，2020，13（6）：e011083 ［18］LIU Y，TIE L. Apolipoprotein M and sphingosine⁃1⁃phos⁃
［6］ PHAN F，BOURRON O，FOUFELLE F，et al. Sphingosine⁃ phate complex alleviates TNF⁃α⁃induced endothelial cell
1 ⁃ phosphate signalling in the heart：exploring emerging injury and inflammation through PI3K/AKT signaling
perspectives in cardiopathology［J］. FEBS Lett，2024，598 pathway［J］. BMC Cardiovasc Disord，2019，19（1）：279
（21）：2641-2655 ［19］ ZHENG H P，YU J J，GAO L H，et al. S1PR1⁃biased
［7］ PIAO J Y，SU Z X，HE J Q，et al. SphK1 deficiency ame⁃ activation drives the resolution of endothelial dysfunction⁃
liorates the development of atherosclerosis by inhibiting associated inflammatory diseases by maintaining endothe⁃
the S1P/S1PR3/Rhoa/ROCK pathway［J］. Cell Signal， lial integrity［J］. Nat Commun，2025，16（1）：1826
2024，121：111252 ［20］ BURG N，MALPASS R，ALEX L，et al. Endothelial cell
［8］ WILKERSON B A，ARGRAVES K M. The role of sphin⁃ sphingosine 1⁃phosphate receptor 1 restrains VE⁃cadherin
gosine ⁃ 1 ⁃ phosphate in endothelial barrier function［J］. cleavage and attenuates experimental inflammatory arthri⁃
Biochim Biophys Acta，2014，1841（10）：1403-1412 tis［J］. JCI Insight，2024，9（11）：e171467
［9］ MEDLIN M D，STAUS D P，DUBASH A D，et al. Sphingo⁃ ［21］TERLIZZI M，COLARUSSO C，SOMMA P，et al. S1P⁃
sine 1⁃phosphate receptor 2 signals through leukemia⁃ induced TNF ⁃ α and IL ⁃ 6 release from PBMCs exacer⁃
associated RhoGEF（LARG），to promote smooth muscle bates lung cancer ⁃ associated inflammation［J］. Cells，
cell differentiation［J］. Arterioscler Thromb Vasc Biol， 2022，11（16）：2524
2010，30（9）：1779-1786 ［22］JIANG H，SHEN S M，YIN J，et al. Sphingosine 1⁃phos⁃
［10］ YASUDA S，SUMIOKA T，IWANISHI H，et al. Loss of phate receptor 1（S1PR1）agonist CYM5442 inhibits
sphingosine 1⁃phosphate receptor 3 gene function impairs expression of intracellular adhesion molecule 1（ICAM1）
injury⁃induced stromal angiogenesis in mouse cornea［J］. in endothelial cells infected with influenza A viruses［J］.
Lab Invest，2021，101（2）：245-257 PLoS One，2017，12（4）：e0175188
［11］NUSSBAUM C，BANNENBERG S，KEUL P，et al. Sphin⁃ ［23］MÜLLER J，VON BERNSTORFF W，HEIDECKE C D，et
gosine⁃1⁃phosphate receptor 3 promotes leukocyte rolling al. Differential S1P receptor profiles on M1⁃and M2⁃polar⁃
by mobilizing endothelial P ⁃ selectin［J］. Nat Commun， ized macrophages affect macrophage cytokine production
2015，6：6416 and migration［J］. Biomed Res Int，2017，2017：7584621
［12］WAFA D N，KOCH N，KOVÁCS J，et al. Opposing roles ［24］ WANG H，HUANG H，DING S F. Sphingosine⁃1⁃phos⁃
of S1P3 receptors in myocardial function［J］. Cells，2020， phate promotes the proliferation and attenuates apoptosis
9（8）：1770 of endothelial progenitor cells via S1PR1/S1PR3/PI3K/
［13］CONSTANTINESCU V，HAASE R，AKGÜN K，et al. S1P Akt pathway［J］. Cell Biol Int，2018，42（11）：1492-1502
receptor modulators and the cardiovascular autonomic ［25］PAIK J H，SKOURA A，CHAE S S，et al. Sphingosine 1⁃
nervous system in multiple sclerosis：a narrative review［J］. phosphate receptor regulation of N ⁃ cadherin mediates
Ther Adv Neurol Disord，2022，15：17562864221133163 vascular stabilization［J］. Genes Dev，2004，18（19）：
［14］VESTRI A，PIERUCCI F，FRATI A，et al. Sphingosine 1⁃ 2392-2403
phosphate receptors：do they have a therapeutic potential ［26］ JI X Q，CHEN Z H，WANG Q Y，et al. Sphingolipid
in cardiac fibrosis［J］. Front Pharmacol，2017，8：296 metabolism controls mammalian heart regeneration［J］.
［15］ WEIGEL C，BELLACI J，SPIEGEL S. Sphingosine ⁃ 1 ⁃ Cell Metab，2024，36（4）：839-856.e8