Page 138 - 南京医科大学自然版

第45卷第12期
·1820 · 南 京 医 科 大 学 学 报 2025年12月

［27］RUTHERFORD C，CHILDS S，OHOTSKI J，et al. Regula⁃ regulates pressure overload⁃induced cardiac remodelling
tion of cell survival by sphingosine⁃1⁃phosphate receptor through AKT⁃ENOS pathway［J］. J Cell Mol Med，2020，
S1P1 via reciprocal ERK⁃dependent suppression of Bim 24（2）：2013-2026
and PI⁃3⁃kinase/protein kinase C⁃mediated upregulation ［40］GALVANI S，SANSON M，BLAHO V A，et al. HDL⁃bound
of Mcl⁃1［J］. Cell Death Dis，2013，4（11）：e927 sphingosine 1⁃phosphate acts as a biased agonist for the
［28］NITZSCHE A，POITTEVIN M，BENARAB A，et al. Endo⁃ endothelial cell receptor S1P1 to limit vascular inflam⁃
thelial S1P1 signaling counteracts infarct expansion in mation［J］. Sci Signal，2015，8（389）：ra79
ischemic stroke［J］. Circ Res，2021，128（3）：363-382 ［41］ LI J Y，FAN Y F，TU W L，et al. Sphingosine⁃1⁃phos⁃
［29］ WANG L Y，ZHANG X W，MA C Y，et al. 1⁃Phosphate phate in the regulation of diabetes mellitus：a scientometric
receptor agonists：a promising therapeutic avenue for isch⁃ study to an in⁃depth review［J］. Front Endocrinol（Laus⁃
emia ⁃ reperfusion injury management［J］. Int Immuno⁃ anne），2024，15：1377601
pharmacol，2024，131：111835 ［42］NAGAHASHI M，YUZA K，HIROSE Y，et al. The roles of
［30］FANG R，ZHANG L L，ZHANG L Z，et al. Sphingosine 1⁃ bile acids and sphingosine⁃1⁃phosphate signaling in the
phosphate postconditioning protects against myocardial hepatobiliary diseases［J］. J Lipid Res，2016，57（9）：
ischemia/reperfusion injury in rats via mitochondrial 1636-1643
signaling and Akt⁃Gsk3β phosphorylation［J］. Arch Med ［43］GREEN C D，MACEYKA M，COWART L A，et al. Sphin⁃
Res，2017，48（2）：147-155 golipids in metabolic disease：the good，the bad，and the
［31］MINATOGUCHI S，YAMADA Y，ENDO N，et al. Sphin⁃ unknown［J］. Cell Metab，2021，33（7）：1293-1306
gosine⁃1⁃phosphate receptor 2 agonist mobilises endoge⁃ ［44］CHAKRABARTY S，BUI Q，BADEANLOU L，et al. S1P/
nous muse cells to repair damaged myocardial tissue in S1PR3 signalling axis protects against obesity ⁃ induced
male rabbits［J］. J Cell Mol Med，2025，29（8）：e70447 metabolic dysfunction［J］. Adipocyte，2022，11（1）：69-
［32］POLZIN A，DANNENBERG L，BENKHOFF M，et al. 83
Sphingosine⁃1⁃phosphate improves outcome of no⁃reflow ［45］ GALLO G，VOLPE M，SAVOIA C. Endothelial dysfunc⁃
acute myocardial infarction via sphingosine⁃1⁃phosphate tion in hypertension：current concepts and clinical impli⁃
receptor 1［J］. ESC Heart Fail，2023，10（1）：334-341 cations［J］. Front Med（Lausanne），2022，8：798958
［33］WANG E，HE X，ZENG M. The role of S1P and the relat⁃ ［46］WAMHOFF B R，LYNCH K R，MACDONALD T L，et al.
ed signaling pathway in the development of tissue fibrosis Sphingosine⁃1⁃phosphate receptor subtypes differentially
［J］. Front Pharmacol，2019，9：1504 regulate smooth muscle cell phenotype［J］. Arterioscler
［34］ JOZEFCZUK E，GUZIK T J，SIEDLINSKI M. Signifi⁃ Thromb Vasc Biol，2008，28（8）：1454-1461
cance of sphingosine⁃1⁃phosphate in cardiovascular phys⁃ ［47］ SAMAH N，UGUSMAN A，HAMID A A，et al. Role of
iology and pathology［J］. Pharmacol Res，2020，156： matrix metalloproteinase⁃2 in the development of athero⁃
104793 sclerosis among patients with coronary artery disease［J］.
［35］ PÉREZ⁃JELDRES T，ALVAREZ⁃LOBOS M，RIVERA⁃ Mediators Inflamm，2023，2023：9715114
NIEVES J. Targeting sphingosine⁃1⁃phosphate signaling ［48］PANTA C R，RUISANCHEZ É，MÓRÉ D，et al. Sphingo⁃
in immune⁃mediated diseases ：beyond multiple sclero⁃ sine⁃1⁃phosphate enhances α1⁃adrenergic vasoconstric⁃
sis［J］. Drugs，2021，81（9）：985-1002 tion via S1P2⁃G12/13 ⁃ROCK mediated signaling［J］. Int J
［36］LIU J J，LIU X M，LUO Y C，et al. Sphingolipids：drivers Mol Sci，2019，20（24）：6361
of cardiac fibrosis and atrial fibrillation［J］. J Mol Med ［49］ BRINKMANN V，BILLICH A，BAUMRUKER T，et al.
（Berl），2024，102（2）：149-165 Fingolimod（FTY720）：discovery and development of an
［37］TULETA I，FRANGOGIANNIS N G. Fibrosis of the diabetic oral drug to treat multiple sclerosis［J］. Nat Rev Drug
heart：clinical significance，molecular mechanisms，and Discov，2010，9（11）：883-897
therapeutic opportunities［J］. Adv Drug Deliv Rev，2021， ［50］CHUN J，KIHARA Y，JONNALAGADDA D，et al. Fingo⁃
176：113904 limod：lessons learned and new opportunities for treating
［38］XIONG Y F，YE Q P，LIU L F，et al. The compensatory multiple sclerosis and other disorders［J］. Annu Rev
enrichment of sphingosine⁃1⁃phosphate on HDL in FSGS Pharmacol Toxicol，2019，59：149-170
enhances the protective function of glomerular endothelial ［51］LIU X X，YUE J N，ZHOU C X，et al. Cardiomyocyte
cells compared to MCD［J］. Sci Rep，2025，15（1）：1530 S1PR1 promotes cardiac regeneration via AKT/mTORC1
［39］ LIU X X，WU J J，ZHU C Y，et al. Endothelial S1PR1 signaling pathway［J］. Theranostics，2025，15（4）：1524-