Page 94 - 南京医科大学自然版

南京医科大学学报（自然科学版） 第45卷第3期
·382 · Journal of Nanjing Medical University（Natural Sciences） 2025年3月

·临床研究·

全身免疫炎症指数对非ST段抬高型心肌梗死患者早期发生急

性心力衰竭的预测价值

张忠满 ，朱 轶 ，陈旭锋 ，王连生 ，武 澎 2*
2
1
1
1
南京医科大学第一附属医院急诊与危重症医学科，心血管内科，江苏 南京 210029
1 2
［摘 要］ 目的：探讨全身免疫炎症指数（systemic immune inflammation index，SII）对非ST段抬高型心肌梗死（non⁃ST⁃elevation
myocardial infarction，NSTEMI）患者早期发生急性心力衰竭（acute heart failure，AHF）的预测价值。方法：采用回顾性研究，收集
2023年9月—2024年9月于南京医科大学第一附属医院心血管内科住院的NSTEMI患者临床资料，通过Spearman相关性分析探
讨入院SII与入院1周内N末端B型利钠肽原（N⁃terminal pro⁃brain natriuretic peptide，NT⁃proBNP）峰值之间的相关性。使用受试
者工作特征（receiver operating characteristic，ROC）曲线和基于Logistic回归的限制性立方样条（restricted cubic spline，RCS）分析探
讨SII与NSTEMI患者早期AHF发生风险间的具体关系。结果：共纳入202例NSTEMI患者，其中104例（51.5%）患者在入院1
周内发生 AHF。AHF 组患者 SII 水平明显高于无 AHF 组患者［1 390.55（939.45，2 459.93）vs. 667.15（431.58，1 140.25），P <
0.001］。ROC 曲线下面积达 0.745（95%CI：0.677~0.812，P < 0.001）。Spearman 相关分析结果显示入院 SII 与入院 1 周内
NT⁃proBNP峰值之间存在线性相关，相关系数为0.317（P < 0.001）。RCS曲线显示，NSTEMI患者早期发生AHF的风险与SII呈
线性正相关。结论：SII对NSTEMI患者早期发生AHF具有预测价值，NSTEMI患者早期发生AHF的风险随SII增加而增加。
［关键词］ 全身免疫炎症指数；非ST段抬高型心肌梗死；急性心力衰竭；限制性立方样条
［中图分类号］ R542.22 ［文献标志码］ A ［文章编号］ 1007⁃4368（2025）03⁃382⁃07
doi：10.7655/NYDXBNSN241381

Predictive value of systemic immune inflammation index for early onset of acute heart

failure in patients with non⁃ST⁃elevation myocardial infarction
1
2
1
1
ZHANG Zhongman ，ZHU Yi ，CHEN Xufeng ，WANG Liansheng ，WU Peng 2*
1 Department of Emergency and Critical Care Medicine，Department of Cardiology，the First Affiliated Hospital of
2
Nanjing Medical University，Nanjing 210029，China
［Abstract］ Objective：To explore the predictive value of the systemic immune inflammation index（SII）for early acute heart failure
（AHF）in non⁃ST⁃elevation myocardial infarction（NSTEMI）patients. Methods：A retrospective study was carried out to collect the
clinical data of NSTEMI patients admitted to the department of Cardiology at the First Affiliated Hospital of Nanjing Medical University
from September 2023 to September 2024. Spearman correlation analysis was employed to investigate the correlation between the
admission SII and the peak value of N⁃terminal pro⁃brain natriuretic peptide（NT⁃proBNP）within one week after admission. Based on
the receiver operating characteristic（ROC）curve and the restricted cubic spline（RCS）based on logistic regression analysis，the
specific relationship between SII and the risk of AHF in NSTEMI patients was explored. Results：A total of 202 NSTEMI patients were
included，among whom 104（51.5% ）developed AHF within one week of admission. The level of SII in patients with AHF was
significantly higher than that in patients without AHF［1 390.55（939.45，2 459.93）vs. 667.15（431.58，1 140.25），P < 0.001］. The
area under the ROC curve was 0.745（95%CI：0.677-0.812，P < 0.001）. Spearman correlation analysis indicated that there was a
linear correlation between the admission SII and the peak value of NT⁃proBNP within one week of admission，and the correlation
coefficient was 0.317（P < 0.001）. The RCS curve demonstrated a linear positive correlation between the risk of early AHF in NSTEMI
patients and SII. Conclusion：The SII exhibits predictive value for the early onset of AHF in NSTEMI patients，with the risk of early
AHF increasing as SII levels rise.
［基金项目］ 国家自然科学基金（82000335）
通信作者（Corresponding author），E⁃mail：wupeng@njmu.edu.cn（ORCID ID：0009⁃0007⁃7881⁃0555）
∗