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第45卷第6期 崔 闯,孙思怡,秦梓一,等. 黄芩苷激活自噬抑制炎症促进牙髓干细胞成牙/骨分化[J].
2025年6月 南京医科大学学报(自然科学版),2025,45(6):766-776 ·775 ·
managed manuscript submission and academic correspondence, logical efficacy of baicalin in inflammatory diseases[J].
and oversaw the entire research process and manuscript quality. Int J Mol Sci,2023,24(11):9317
[参考文献] [13]LEVINE B,MIZUSHIMA N,VIRGIN H W. Autophagy in
immunity and inflammation[J]. Nature,2011,469
[1] TOMSON P L,VILELA BASTOS J,JACIMOVIC J,et al.
(7330):323-335
Effectiveness of pulpotomy compared with root canal treat⁃
[14] SUN X Q,PISANO M,XU L J,et al. Baicalin regulates
ment in managing non⁃traumatic pulpitis associated with
autophagy to interfere with small intestinal acute graft ⁃
spontaneous pain:a systematic review and meta⁃analysis
versus⁃host disease[J]. Sci Rep,2022,12(1):6551
[J]. Int Endod J,2023,56(Suppl 3):355-369
[15] ZHANG L L,YU G X,YU Q,et al. Baicalin promotes
[2] ERDOGAN O,XIA J Y,CHIU I M,et al. Dynamics of
random⁃pattern skin flap survival by inducing autophagy
innate immune response in bacteria⁃induced mouse model
via AMPK⁃regulated TFEB nuclear transcription[J]. Phy⁃
of pulpitis[J]. J Endod,2023,49(11):1529-1536
tother Res,2023,37(9):3926-3938
[3] GALLER K M,WEBER M,KORKMAZ Y,et al. Inflam⁃
[16]LI M Y,WANG Y M,XUE J,et al. Baicalin can enhance
matory response mechanisms of the dentine⁃pulp complex
odonto/osteogenic differentiation of inflammatory dental
and the periapical tissues[J]. Int J Mol Sci,2021,22(3):
pulp stem cells by inhibiting the NF⁃κB and β⁃catenin/
1480 Wnt signaling pathways[J]. Mol Biol Rep,2023,50(5):
[4] ZAKY S H,SHEHABELDIN M,RAY H,et al. The role
4435-4446
of inflammation modulation in dental pulp regeneration
[17]HU Z Q,CHEN Y Y,HE J,et al. EZH2 might affect mac⁃
[J]. Eur Cell Mater,2021,41:184-193
rophage chemotaxis and anti⁃inflammatory factors by regu⁃
[5] YOSHIBA N,EDANAMI N,OHKURA N,et al. M2
lating CCL2 in dental pulp inflammation[J]. Stem Cells
phenotype macrophages colocalize with schwann cells in
Int,2021,2021:3060480
human dental pulp[J]. J Dent Res,2020,99(3):329- [18]李梦圆,王宇萌,徐青清,等. 活化α7 乙酰胆碱受体促
338 进LPS刺激的人牙髓干细胞牙/骨向分化[J]. 南京医科
[6] HE Y,GAN Y H,LU J J,et al. Pulpal tissue inflammatory
大学学报(自然科学版),2024,44(2):145-153
reactions after experimental pulpal exposure in mice[J]. LI M Y,WANG Y M,XU Q Q,et al. Activation of α7
J Endod,2017,43(1):90-95
nicotinic acetylcholine receptors promotes LPS⁃stimulated
[7] KARRAR R N,CUSHLEY S,DUNCAN H F,et al. Mo⁃ odontogenic/osteogenic differentiation of human dental
lecular biomarkers for objective assessment of symptomatic
pulp stem cells[J]. Journal of Nanjing Medical University
pulpitis:a systematic review and meta ⁃ analysis[J]. Int (Natural Sciences),2024,44(2):145-153
Endod J,2023,56(10):1160-1177 [19] GUO D H,DONG W,CONG Y Q,et al. LIF aggravates
[8] RENARD E,GAUDIN A,BIENVENU G,et al. Immune pulpitis by promoting inflammatory response in macro⁃
cells and molecular networks in experimentally induced phages[J]. Inflammation,2024,47(1):307-322
pulpitis[J]. J Dent Res,2016,95(2):196-205 [20]WANG C,MA C,GONG L H,et al. Macrophage polariza⁃
[9] WEN R J,DONG X,ZHUANG H W,et al. Baicalin induces tion and its role in liver disease[J]. Front Immunol,
ferroptosis in osteosarcomas through a novel Nrf2/xCT/ 2021,12:803037
GPX4 regulatory axis[J]. Phytomedicine,2023,116: [21]HE J,HE J. Baicalin mitigated IL⁃1β⁃induced osteoarthri⁃
154881 tis chondrocytes damage through activating mitophagy
[10]LI S S,SUN X X,XU L X,et al. Baicalin attenuates in [J]. Chem Biol Drug Des,2023,101(6):1322-1334
vivo and in vitro hyperglycemia ⁃ exacerbated ischemia/ [22] LIAO H F,YE J,GAO L L,et al. The main bioactive
reperfusion injury by regulating mitochondrial function in compounds of Scutellaria baicalensis Georgi. for allevia⁃
a manner dependent on AMPK[J]. Eur J Pharmacol, tion of inflammatory cytokines:a comprehensive review
2017,815:118-126 [J]. Biomed Pharmacother,2021,133:110917
[11] GUO L T,WANG S Q,SU J,et al. Baicalin ameliorates [23] XU M,LI X Y,SONG L C. Baicalin regulates macro⁃
neuroinflammation ⁃ induced depressive ⁃ like behavior phages polarization and alleviates myocardial ischaemia/
through inhibition of toll ⁃ like receptor 4 expression via reperfusion injury via inhibiting JAK/STAT pathway[J].
the PI3K/AKT/FoxO1 pathway[J]. J Neuroinflammation, Pharm Biol,2020,58(1):655-663
2019,16(1):95 [24]WANG C,YANG Y L,SUN L N,et al. Baicalin reverses
[12]WEN Y Q,WANG Y Z,ZHAO C X,et al. The pharmaco⁃ radioresistance in nasopharyngeal carcinoma by downre ⁃

