Page 59 - 南京医科大学自然版
P. 59

第45卷第6期     戈艳蕾,孙思怡,任泓沁,等. scRNA⁃seq和Bulk RNA⁃seq联合分析揭示MTRNR2L1介导COPD进展中
                  2025年6月              PANoptosis下调[J]. 南京医科大学学报(自然科学版),2025,45(6):786-797              ·797 ·


                   (Suppl 17):S2129-S2140                              visualization of single⁃cell RNA⁃seq data in R[J]. Bioin⁃
               [13]GÓRSKI P,BIAŁAS A J,PIOTROWSKI W J. Aging lung:     formatics,2017,33(8):1179-1186

                    molecular drivers and impact on respiratory diseases ⁃ a  [23]STUART T,BUTLER A,HOFFMAN P,et al. Comprehen⁃
                    narrative clinical review[J]. Antioxidants(Basel),2024,  sive integration of single ⁃ cell data[J]. Cell,2019,177
                    13(12):1480                                       (7):1888⁃1902.e21
               [14]MCDONOUGH J E,YUAN R,SUZUKI M,et al. Small⁃   [24]EAPEN M S,HANSBRO P M,LARSSON⁃CALLERFELT
                    airway obstruction and emphysema in chronic obstructive  A K,et al. Chronic obstructive pulmonary disease and
                    pulmonary disease[J]. N Engl J Med,2011,365(17):   lung cancer:underlying pathophysiology and new thera⁃
                    1567-1575                                          peutic modalities[J]. Drugs,2018,78(16):1717-1740
               [15]张哲明,吴       艳,邸婷婷,等. microRNA let⁃7 在 COPD    [25]FU X Y,YANG X L,CUI X L,et al. Overlapping and seg⁃
                    稳定期男性患者血清中的表达及临床意义[J]. 南京医                         regated changes of functional hubs in melancholic depres⁃

                    科大学学报(自然科学版),2023,43(2):230-235                    sion and non⁃melancholic depression[J]. J Psychiatr Res,
                    ZHANG Z M,WU Y,DI T T,et al. Expression and clini⁃  2022,154:123-131
                    cal significance of microRNA let 7 in male serum of sta⁃  [26]SAKURAI H. Targeting of TAK1 in inflammatory disor⁃
                    ble COPD[J]. Journal of Nanjing Medical University(Nat⁃  ders and cancer[J]. Trends Pharmacol Sci,2012,33
                    ural Sciences),2023,43(2):230-235                 (10):522-530
               [16]段榆琳,王宋平. 探讨 AECOPD 患者血清 ACE2 和 NLR            [27]CAO X Y,TAN J L,ZHENG R X,et al. Targeting necrop⁃
                    水平与 CAT 评分的相关性[J].南京医科大学学报(自                       tosis :a promising avenue for respiratory disease treat⁃
                    然科学版),2019,39(7):997-999                           ment[J]. Cell Commun Signal,2024,22(1):418
                    DUAN Y L,WANG S P. To explore the correlation be⁃  [28]ZHANG Z Z,MEI X Z,WANG H,et al. Long non⁃coding
                    tween serum ACE2 and NLR levels and CAT scores in  RNA MMTP mediates necroptosis in alveolar macro⁃
                    AECOPD patients[J]. Journal of Nanjing Medical Univer⁃  phages during Mycoplasma hyopneumoniae infection by
                    sity(Natural Sciences),2019,39(7):997-999          enhancing TNF⁃α transcription[J]. Int J Biol Macromol,
               [17]POLVERINO F,SIN D D. Type 2 airway inflammation in  2025,288:138649
                    COPD[J]. Eur Respir J,2024,63(5):2400150     [29]SHI R,LIANG R W,WANG F,et al. Identification and
               [18]CHRISTGEN S,TWEEDELL R E,KANNEGANTI T D.            experimental validation of PYCARD as a crucial PANop⁃
                    Programming inflammatory cell death for therapy[J].  tosis⁃related gene for immune response and inflammation
                    Pharmacol Ther,2022,232:108010                     in COPD[J]. Apoptosis,2024,29(11/12):2091-2107
               [19]HEWITT R J,LLOYD C M. Regulation of immune re⁃  [30]BLAKE D,RADENS C M,FERRETTI M B,et al. Alterna⁃
                    sponses by the airway epithelial cell landscape[J]. Nat  tive splicing of apoptosis genes promotes human T cell
                    Rev Immunol,2021,21(6):347-362                     survival[J]. Elife,2022,11:e80953
               [20]RUYSSEVELDT E,MARTENS K,STEELANT B. Airway    [31]SUN X,YANG Y P,MENG X N,et al. PANoptosis:Mech⁃
                    basal cells,protectors of epithelial walls in health and  anisms,biology,and role in disease[J]. Immunol Rev,
                    respiratory diseases[J]. Front Allergy,2021,2:787128  2024,321(1):246⁃262
               [21]BECHT E,GIRALDO N A,LACROIX L,et al. Estimating  [32]VAN EECKHOUTTE H P,DONOVAN C,KIM R Y,et al.
                    the population abundance of tissue ⁃ infiltrating immune  RIPK1 kinase ⁃ dependent inflammation and cell death
                    and stromal cell populations using gene expression[J].  contribute to the pathogenesis of COPD[J]. Eur Respir J.
                    Genome Biol,2016,17(1):218                         2023,61(4):2201506
               [22]MCCARTHY D J,CAMPBELL K R,LUN A T L,et al.                              [收稿日期] 2024-07-10
                    Scater:pre⁃processing,quality control,normalization and                     (本文编辑:戴王娟)
   54   55   56   57   58   59   60   61   62   63   64