Page 146 - 南京医科大学自然版

南京医科大学学报（自然科学版） 第45卷第8期
·1202 · Journal of Nanjing Medical University（Natural Sciences） 2025年8月

·综 述·

产甲胎蛋白胃癌生物学特征及治疗策略的研究进展

刘雨清 ，马 玲 1，2，3 ，束永前 1，2*
1
南京医科大学第一附属医院肿瘤科，江苏 南京 210029；南京医科大学肿瘤个体化医学协同创新中心，江苏 南京
1 2
210029；睢宁县人民医院肿瘤内科，江苏 徐州 221200
3

［摘 要］ 胃癌的全球发病率和死亡率始终维持在较高水平，中国因胃癌导致的疾病负担明显高于全球平均水平，死亡率在
国内恶性肿瘤中排第3位。产甲胎蛋白胃癌（alpha⁃fetoprotein⁃producing gastric cancer，AFPGC）以血清甲胎蛋白（alpha⁃fetopro⁃
tein，AFP）异常升高或肿瘤组织免疫组化AFP阳性为特征，占国内胃癌的2.3%~4.6%。AFPGC较一般胃癌更易发生远处转移
尤其是肝转移，预后更差，当前尚无规范的治疗指南，主要依赖传统的胃癌治疗方法。已有一些研究正在探索这一类型恶性肿
瘤与一般胃癌发生发展的差异，以及相关临床特征和治疗疗效。文章围绕国内外关于AFPGC生物学特性、临床病理特征及当
前治疗探索的相关研究作一综述。
［关键词］ 产甲胎蛋白胃癌；临床病理特征；免疫治疗；抗血管治疗
［中图分类号］ R735.2 ［文献标志码］ A ［文章编号］ 1007⁃4368（2025）08⁃1202⁃09
doi：10.7655/NYDXBNSN250433

Advances in the biological characteristics and therapeutic strategies of alpha⁃fetoprotein⁃
producing gastric cancer

1
LIU Yuqing ，MA Ling 1，2，3 ，SHU Yongqian 1，2*
2
1 Department of Oncology，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029；Collaborative
Innovation Center for Cancer Personalized Medicine，Nanjing Medical University，Nanjing 210029；Department of
3
Oncology，Suining People’s Hospital，Xuzhou 221200，China

［Abstract］ The global incidence and mortality rates of gastric cancer remain high. China bears a significantly higher disease burden
from gastric cancer than the global average，with its mortality ranking third among all malignant tumors in the country. Alpha ⁃
fetoprotein⁃producing gastric cancer（AFPGC）is a special subtype of gastric cancer characterized by abnormally elevated serum alpha⁃
fetoprotein（AFP）levels or positive AFP expression in tumor tissues detected by immunohistochemistry. The incidence of AFPGC in
China accounts for approximately 2.3%⁃4.6% of gastric cancer cases. Compared with conventional gastric cancer，AFPGC is more
prone to distant metastasis，particularly liver metastasis，and has a poorer prognosis. Currently，there are no standardized treatment
guidelines for AFPGC，and its management primarily relies on conventional gastric cancer treatment strategies. Research is ongoing to
explore the differences between the occurrence and development of this tumor and general gastric cancer，as well as the related clinical
features and efficacy of therapy. This article mainly reviews the biological features，clinicopathological characteristics and current
treatment explorations of AFPGC in domestic and foreign research.
［Key words］ alpha⁃fetoprotein⁃producing gastric cancer；clinicopathological characteristics；immunotherapy；anti⁃angiogenic therapy
［J Nanjing Med Univ，2025，45（08）：1202⁃1210］

［基金项目］ 国家自然科学基金（82102981，82172889）；中国博士后科学基金（2024M751224）；江苏高校“青蓝工程”希思科⁃
朝阳肿瘤研究基金项目（Y⁃Young2024⁃0152）；部省共建肿瘤个体化医学协调创新中心青年项目（2024CICCPMHR033）；南京市
博士后科研项目；江苏省人民医院⁃东南大学医工交叉转化基金⁃器官芯片⁃重点项目（QG202402）
通信作者（Corresponding author），E⁃mail：shuyongqian@csco.org.cn（ORICD：0000⁃0003⁃2103⁃0877）
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