Page 31 - 南京医科大学自然版

第45卷第8期 唐 昊，卢泓成，胡 强. TRIM家族蛋白在肾脏疾病中的研究进展［J］.
2025年8月 南京医科大学学报（自然科学版），2025，45（8）：1082-1091 ·1087 ·

表1 TRIM家族蛋白与肾脏疾病
Table 1 TRIM family proteins and kidney diseases

The classification
Experiment model Result Specific mechanism
of TRIM
TRIM18 6⁃week⁃old male C57BL/KsJ mice；HK⁃2 Pro⁃fibrotic Promotes PTP1B ubiquitination and activates the
［23］
STAT3 signaling pathway
TRIM13 Renal biopsy specimens；C57BL/6 mouse DN Anti⁃fibrotic Ubiquitination and degradation of CHOP protein, inhibit⁃
［24］
model；db/db mouse DN model；mouse glomerular ing the expression of collagen⁃related factors
mesangial cells；human glomerular mesangial cell
line CC⁃2559 cells
TRIM21 HK⁃2；C57BL/6N background mice Anti⁃fibrotic Promotes PFKP ubiquitination and degradation, regulat⁃
［25］
ing aerobic glycolysis in renal tubular cells
TRIM21& Renal cancer cell line；lung cancer cell line；nor⁃ Tumor⁃modulating Both activate the proteasomal pathway through K48 ⁃
TRIM8 mal lung epithelial cells；embryonic renal cells； linked ubiquitination ［26］
non ⁃ small cell lung cancer tissue microarray；
RCC tissue microarray
TRIM65 Renal cancer cell line；HK⁃2；nude mouse xeno⁃ Pro⁃carcinogenic TRIM65⁃BTG3⁃CyclinD1 axis ［27］
graft model
［28］
TRIM47 Renal cancer cell line；male BALB/c⁃nu nude mice Pro⁃carcinogenic Promotes P53 ubiquitination and degradation
TRIM26 Renal cancer cell line；HK⁃2；4⁃week⁃old male Anti⁃ carcinogenic Promotes ETK ubiquitination and degradation, thereby
［29］
BALB/c⁃nu nude mice inactivating the AKT/mTOR signaling pathway
-/-
C57BL/6 background Trim26 mice；bone marrow Anti⁃inflammatory Limits inflammatory neutrophil infiltration and pro ⁃ in⁃
［50］
chimeric mice；Candida albicans strain SC5314 flammatory cytokine production
TRIM8 H/R model Pro⁃renal injury Activates the PI3K/Akt signaling pathway and increases
［35］
ROS and hydrogen peroxide levels
TRIM22 HK⁃2；8⁃week⁃old male C57BL/KsJ mice Pro⁃fibrotic WTAP/IGF2BP1⁃TRIM22⁃OPA1 axis ［36］
TRIM16 db/db mice and db/m mice；MPC5 mouse podo⁃ Pro⁃inflammatory Decreases SOD and CAT levels while increasing intra⁃
cyte cell line cellular ROS, IL⁃6, and TNF⁃α ［37］
TRIM39 HK⁃2；HEK293T cells；UUO mouse model Pro⁃fibrotic Promotes PRDX3 ubiquitination and degradation, lead⁃
ing to ROS accumulation and increased production of in⁃
［38］
flammatory cytokines
TRIM27 HK⁃2；renal cancer cell line；nude mouse xeno⁃ Pro⁃carcinogenic Promotes IκBα ubiquitination and activates the NF⁃κB
graft tumor model signaling pathway ［46］
Human glomerular endothelial cells；female MRL/ Pro⁃inflammatory Activation of Akt upregulates TRIM27 expression and
lpr mice and MRL/MPJ mice activates the FoxO1 signaling pathway ［52］
TRIM6 HK⁃2；Sprague⁃Dawley rats Pro⁃fibrotic Promotes TSC1 and TSC2 ubiquitination and activates
［47］
the mTORC1 signaling pathway
TRIM72 UUO mouse model Anti⁃fibrotic MG53 binds to p65, inhibiting nuclear translocation and
（MG53） activation of NF⁃κB ［48］
TRIM40 In vitro IgA1⁃induced glomerular mesangial cell Anti⁃inflammatory Promotes NLRP3 ubiquitination and regulates NLRP3
model inflammasome activation ［51］
TRIM36 Renal clear cell carcinoma cell line；human Pro⁃carcinogenic Modulates tumor immune escape mechanisms ［53］
embryonic kidney cell line
TRIM28 Human tumor specimens Anti⁃ carcinogenic Abnormal loss of TRIM28 expression leads to embryonic
kidney developmental abnormalities and induces tumori⁃
genesis ［56⁃59］
TRIM37 Human renal cell carcinoma cell line；subcutane⁃ Pro⁃carcinogenic Histone H2A ubiquitination activates the TGF ⁃ β1/
ous xenograft tumor model；metastatic xenograft Smad2/3 signaling pathway ［55］
tumor model
TRIM44 Human renal carcinoma cell line Pro⁃carcinogenic Inhibits FRK, promoting RCC cell proliferation and mi⁃
gration ［64］