Page 34 - 南京医科大学自然版
P. 34
第45卷第8期
·1090 · 南 京 医 科 大 学 学 报 2025年8月
STAT3 signaling pathway via PTP1B promotes renal induced injury by inhibiting oxidative stress ⁃ mediated
epithelial ⁃ mesenchymal transition ,inflammation ,and apoptosis and pyroptosis via PI3K/Akt signal pathway[J].
fibrosis in diabetic kidney disease[J]. Front Physiol, Drug Des Devel Ther,2021,15:4973-4983
2021,12:709506 [36] ZHANG Z,ZHOU F Z,LU M,et al. WTAP ⁃ mediated
[24]LI Y B,REN D J,SHEN Y F,et al. Altered DNA methyla⁃ m6A modification of TRIM22 promotes diabetic nephrop⁃
tion of TRIM13 in diabetic nephropathy suppresses athy by inducing mitochondrial dysfunction via ubiqui⁃
mesangial collagen synthesis by promoting ubiquitination tination of OPA1[J]. Redox Rep,2024,29(1):2404794
of CHOP[J]. EBioMedicine,2020,51:102582 [37]ZHENG R,XU Q,WANG Y W,et al. Cordyceps cicadae
[25]WEN Y,TIAN M Q,JIANG X S,et al. Trim21 mediates polysaccharides attenuate diabetic nephropathy via the
metabolic reprogramming in renal tubular cells via PFKP miR⁃30a⁃3p/TRIM16 axis[J]. J Diabetes Investig,2024,
ubiquitination to alleviate renal fibrosis[J]. J Cell Physiol, 15(3):300-314
2024,239(12):e31439 [38]JIAN J,LIU Y X,ZHENG Q Y,et al. The E3 ubiquitin
[26] WANG L,LI H,HUANG A X,et al. Mutual regulation ligase TRIM39 modulates renal fibrosis induced by unilat⁃
between TRIM21 and TRIM8 via K48⁃linked ubiquitina⁃ eral ureteral obstruction through regulating proteasomal
tion[J]. Oncogene,2023,42(50):3708-3718 degradation of PRDX3[J]. Cell Death Discov,2024,10
[27]ZHANG Q,LI Y,ZHU Q,et al. TRIM65 promotes renal (1):17
cell carcinoma through ubiquitination and degradation of [39]SONG I S,JEONG Y J,JEONG S H,et al. FOXM1⁃
BTG3[J]. Cell Death Dis,2024,15(5):355 induced PRX3 regulates stemness and survival of colon
[28] CHEN J X,XU D,CAO J W,et al. TRIM47 promotes cancer cells via maintenance of mitochondrial function[J].
malignant progression of renal cell carcinoma by degrad⁃ Gastroenterology,2015,149(4):1006-1016
ing P53 through ubiquitination[J]. Cancer Cell Int,2021, [40]LIANG Z,TANG Z W,ZHU C J,et al. Intestinal CXCR6 +
21(1):129 ILC3s migrate to the kidney and exacerbate renal fibrosis
[29] ZHENG D,NING J Z,DENG H,et al. TRIM26 inhibits via IL⁃23 receptor signaling enhanced by PD⁃1 expression
clear cell renal cell carcinoma progression through desta⁃ [J]. Immunity,2024,57(6):1306-1323
bilizing ETK and thus inactivation of AKT/mTOR signal⁃ [41]TANAKA S,ZHENG S Q,KHAREL Y,et al. Sphingosine
ing[J]. J Transl Med,2024,22(1):481 1 ⁃ phosphate signaling in perivascular cells enhances
[30] HU J J,WANG H W,LI X T,et al. Fibrinogen⁃like inflammation and fibrosis in the kidney[J]. Sci Transl
protein 2 aggravates nonalcoholic steatohepatitis via inter⁃ Med,2022,14(658):eabj2681
action with TLR4,eliciting inflammation in macrophages [42]BAUMANN B,WAGNER M,ALEKSIC T,et al. Constitu⁃
and inducing hepatic lipid metabolism disorder[J]. Ther⁃ tive IKK2 activation in acinar cells is sufficient to induce
anostics,2020,10(21):9702-9720 pancreatitis in vivo[J]. J Clin Invest,2007,117(6):
[31]SASTRE J,PÉREZ S,SABATER L,et al. Redox signal⁃ 1502-1513
ing in the pancreas in health and disease[J]. Physiol [43]HU S K,RUSSELL J O,LIU S,et al. β⁃Catenin⁃NF⁃κB⁃
Rev,2025,105(2):593-650 CFTR interactions in cholangiocytes regulate inflamma⁃
[32]QIU D J,SONG S,CHEN N,et al. NQO1 alleviates renal tion and fibrosis during ductular reaction[J]. Elife,2021,
fibrosis by inhibiting the TLR4/NF⁃κB and TGF⁃β/Smad 10:e71310
signaling pathways in diabetic nephropathy[J]. Cell Sig⁃ [44]CHAN L K,GERSTENLAUER M,KONUKIEWITZ B,et
nal,2023,108:110712 al. Epithelial NEMO/IKKγ limits fibrosis and promotes
[33]LIN W Y,TSAI W L,SHAO R X,et al. Hepatitis C virus regeneration during pancreatitis[J]. Gut,2017,66(11):
regulates transforming growth factor beta1 production 1995-2007
through the generation of reactive oxygen species in a [45]LI F J,SUROLIA R,LI H S,et al. Citrullinated vimentin
nuclear factor kappaB⁃dependent manner[J]. Gastroen⁃ mediates development and progression of lung fibrosis[J].
terology,2010,138(7):2509-2518,2518.e1 Sci Transl Med,2021,13(585):eaba2927
[34] LI N,WU X F,HOLZER R G,et al. Loss of acinar cell [46]XIAO C W,ZHANG W,HUA M M,et al. TRIM27 inter⁃
IKKα triggers spontaneous pancreatitis in mice[J]. J acts with Iκbα to promote the growth of human renal
Clin Invest,2013,123(5):2231-2243 cancer cells through regulating the NF ⁃ κB pathway[J].
[35]ZHANG B H,LIU H,YUAN Y,et al. Knockdown of BMC Cancer,2021,21(1):841
TRIM8 protects HK⁃2 cells against hypoxia/reoxygenation⁃ [47] LIU W W,YI Y,ZHANG C F,et al. The expression of

