Page 33 - 南京医科大学自然版

第45卷第8期 唐 昊，卢泓成，胡 强. TRIM家族蛋白在肾脏疾病中的研究进展［J］.
2025年8月 南京医科大学学报（自然科学版），2025，45（8）：1082-1091 ·1089 ·

work of the paper，and completing the overall writing of the pa⁃ ［11］ DJUDJAJ S，BOOR P. Cellular and molecular mecha⁃
per. LU Hongcheng participated in the selection of the research nisms of kidney fibrosis［J］. Mol Aspects Med，2019，65：
topic and the determination of the main direction, contributed to 16-36
the review and revision of the paper，and provided valuable sug⁃ ［12］YANG G Y，XIANG J Q，YANG X X，et al. Nuclear trans⁃
gestions regarding the logical structure，language expression， location of SIRT4 mediates deacetylation of U2AF2 to
and academic rigor of the manuscript. HU Qiang participated in modulate renal fibrosis through alternative splicing⁃medi⁃
the review and revision of the paper，provided valuable sugges⁃ ated upregulation of CCN2［J］. Elife，2024，13：RP98524
tions on the logical structure，language expression，and academ⁃ ［13］YANG B S，WANG Z X，NIU K F，et al. TRIM35 triggers
ic standardization of the paper，and proofread the final draft of cardiac remodeling by regulating SLC7A5 ⁃ mediated
the paper. amino acid transport and mTORC1 activation in fibro⁃
blasts［J］. Cell Commun Signal，2024，22（1）：444
［参考文献］
［14］ SEO H Y，LEE S H，HAN E，et al. Increased levels of
［1］ HATAKEYAMA S. TRIM proteins and cancer［J］. Nat
phosphorylatedERKinduceCTGFexpressioninautophagy⁃
Rev Cancer，2011，11（11）：792-804 deficient mouse hepatocytes［J］. Cells，2022，11（17）：
［2］ HUANG N，SUN X L，LI P，et al. TRIM family contribute
2704
to tumorigenesis，cancer development，and drug resistance
［15］CATHCART A M，BIRD G H，WALES T E，et al. Target⁃
［J］. Exp Hematol Oncol，2022，11（1）：75
ing a helix ⁃ in ⁃ groove interaction between E1 and E2
［3］ ZHAO G，LIU C，WEN X，et al. The translational values
blocks ubiquitin transfer［J］. Nat Chem Biol，2020，16
of TRIM family in pan⁃cancers：from functions and mech⁃
（11）：1218-1226
anisms to clinics［J］. Pharmacol Ther，2021，227：107881
［16］TIMMS R T，MENA E L，LENG Y M，et al. Defining E3
［4］ HATAKEYAMA S. TRIM family proteins：roles in autoph⁃
ligase⁃substrate relationships through multiplex CRISPR
agy，immunity，and carcinogenesis［J］. Trends Biochem screening［J］. Nat Cell Biol，2023，25（10）：1535-1545
Sci，2017，42（4）：297-311
［17］ MATIUHIN Y，KIRKPATRICK D S，ZIV I，et al. Extra⁃
［5］ GIRALDO M I，HAGE A，VAN TOL S，et al. TRIM proteasomal Rpn10 restricts access of the polyubiquitin⁃
proteins in host defense and viral pathogenesis［J］. Curr binding protein Dsk2 to proteasome［J］. Mol Cell，2008，
Clin Microbiol Rep，2020，7（4）：101-114 32（3）：415-425
［6］ ZHU Y，AFOLABI L O，WAN X C，et al. TRIM family ［18］FURUHATA T，CHOI B，UNO T，et al. Chemical diversi⁃
proteins：roles in proteostasis and neurodegenerative fication of enzymatically assembled polyubiquitin chains
diseases［J］. Open Biol，2022，12（8）：220098 to decipher the ubiquitin codes programmed on the
［7］ SHEN J W，WANG R J，CHEN Y，et al. Comprehensive branch structure［J］. J Am Chem Soc，2024
analysis of expression profiles and prognosis of TRIM ［19］CHURCH T R，MARGOLIS S S. Mechanisms of ubiquitin⁃
genes in human kidney clear cell carcinoma［J］. Aging independent proteasomal degradation and their roles in
（Albany NY），2022，14（10）：4606-4617 age⁃related neurodegenerative disease［J］. Front Cell Dev
［8］ ZHENG D，ZHANG Y L，XIA Y Q，et al. A novel gene Biol，2025，12：1531797
signature of tripartite motif family for predicting the prog⁃ ［20］CHEN X W，XIAO J，TAO D P，et al. Metadherin orches⁃
nosis in kidney renal clear cell carcinoma and its associa⁃ trates PKA and PKM2 to activate β⁃catenin signaling in
tion with immune cell infiltration［J］. Front Oncol，2022， podocytes during proteinuric chronic kidney disease［J］.
12：840410 Transl Res，2024，266：68-83
［9］ WU G Z，XU Y K，LI L，et al. Tripartite ⁃ motif family ［21］LU J H，SUN W W，LIU B Y，et al. Chk2 modulates Bmi1⁃
genes associated with cancer stem cells affect tumor deficiency⁃induced renal aging and fibrosis via oxidative
progression and can assist in the clinical prognosis of stress，DNA damage，and p53/TGFβ1⁃induced epithelial⁃
kidney renal clear cell carcinoma［J］. Int J Med Sci， mesenchymal transition［J］. Int J Biol Sci，2024，20（6）：
2020，17（18）：2905-2916 2008-2026
［10］ Writing Group for the CKD Prognosis Consortium， ［22］MCDANIELS J M，SHETTY A C，KUSCU C，et al. Single
GRAMS M E，CORESH J，et al. Estimated glomerular nuclei transcriptomics delineates complex immune and
filtration rate，albuminuria，and adverse outcomes：an kidney cell interactions contributing to kidney allograft
individual ⁃ participant data meta ⁃ analysis［J］. JAMA， fibrosis［J］. Kidney Int，2023，103（6）：1077-1092
2023，330（13）：1266-1277 ［23］CHEN Q，GAO C，WANG M，et al. TRIM18 ⁃ regulated