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第46卷第1期 吴心宇，凌 蕊，朱文宇. 老年结直肠癌患者术后辅助治疗与个体化治疗研究进展［J］.
2026年1月 南京医科大学学报（自然科学版），2026，46（1）：31-38，46 · 37 ·

Oxaliplatin combined with weekly bolus fluorouracil and 317-324
leucovorin as surgical adjuvant chemotherapy for stage Ⅱ ［18］BEKKI T，SHIMOMURA M，SAITO Y，et al. Association
and Ⅲ colon cancer：results from NSABP C⁃07［J］. J Clin between social background and implementation of postop⁃
Oncol，2007，25（16）：2198-2204 erative adjuvant chemotherapy for older patients undergo⁃
［9］ GROTHEY A，SOBRERO A F，SHIELDS A F，et al. ing curative resection of colorectal cancers，sub⁃analysis
Duration of adjuvant chemotherapy for stage Ⅲ colon of the HiSCO⁃04 study［J］. Int J Colorectal Dis，2023，39
cancer［J］. N Engl J Med，2018，378（13）：1177-1188 （1）：11
［10］MCCLEARY N J，MEYERHARDT J A，GREEN E，et al. ［19］BAHADOER R R，DIJKSTRA E A，VAN ETTEN B，et al.
Impact of age on the efficacy of newer adjuvant therapies Short⁃course radiotherapy followed by chemotherapy be⁃
in patients with stage Ⅱ/Ⅲ colon cancer：findings from fore total mesorectal excision（TME）versus preoperative
the ACCENT database［J］. J Clin Oncol，2013，31（20）： chemoradiotherapy，TME，and optional adjuvant chemo⁃
2600-2606 therapy in locally advanced rectal cancer（RAPIDO）：a
［11］TAKASHIMA A，HAMAGUCHI T，MIZUSAWA J，et al. randomised，open⁃label，phase 3 trial［J］. Lancet Oncol，
Oxaliplatin added to fluoropyrimidine/bevacizumab as ini⁃ 2021，22（1）：29-42
tial therapy for unresectable metastatic colorectal cancer ［20］CONROY T，BOSSET J F，ETIENNE P L，et al. Neoadju⁃
in older patients：a multicenter，randomized，open ⁃ label vant chemotherapy with FOLFIRINOX and preoperative
phase Ⅲ trial（JCOG1018）［J］. J Clin Oncol，2024，42 chemoradiotherapy for patients with locally advanced rec⁃
（33）：3967-3976 tal cancer（UNICANCER⁃PRODIGE 23）：a multicentre，
［12］HALLER D G，O’CONNELL M J，CARTWRIGHT T H， randomised，open⁃label，phase 3 trial［J］. Lancet Oncol，
et al. Impact of age and medical comorbidity on adjuvant 2021，22（5）：702-715
treatment outcomes for stage Ⅲ colon cancer：a pooled ［21］SCOTT A J，KENNEDY E B，BERLIN J，et al. Manage⁃
analysis of individual patient data from four randomized， ment of locally advanced rectal cancer：ASCO guideline［J］.
controlled trials［J］. Ann Oncol，2015，26（4）：715-724 J Clin Oncol，2024，42（28）：3355-3375
［13］BREUGOM A J，VAN GIJN W，MULLER E W，et al. Ad⁃ ［22］BENSON A B，VENOOK A P，AL⁃HAWARY M M，et al.
juvant chemotherapy for rectal cancer patients treated Rectal cancer，version 2.2022，NCCN clinical practice
with preoperative（chemo）radiotherapy and total mesorec⁃ guidelines in oncology［J］. J Natl Compr Canc Netw，
tal excision：a Dutch Colorectal Cancer Group（DCCG） 2022，20（10）：1139-1167
randomized phase Ⅲ trial［J］. Ann Oncol，2015，26（4）： ［23］HOFHEINZ R D，FOKAS E，BENHAIM L，et al. Lo⁃
696-701 calised rectal cancer：ESMO clinical practice guideline
［14］HONG Y S，KIM S Y，LEE J S，et al. Oxaliplatin⁃based for diagnosis，treatment and follow ⁃ up［J］. Ann Oncol，
adjuvant chemotherapy for rectal cancer after preopera⁃ 2025，36（9）：1007-1024
tive chemoradiotherapy（ADORE）：long⁃term results of a ［24］VERHEIJ F S，OMER D M，WILLIAMS H，et al. Long⁃
randomized controlled trial［J］. J Clin Oncol，2019，37 term results of organ preservation in patients with rectal
（33）：3111-3123 adenocarcinoma treated with total neoadjuvant therapy：
［15］SAUER R，LIERSCH T，MERKEL S，et al. Preoperative the randomized phase Ⅱ OPRA trial［J］. J Clin Oncol，
versus postoperative chemoradiotherapy for locally ad⁃ 2024，42（5）：500-506
vanced rectal cancer：results of the German CAO/ARO/ ［25］SHI Y K，BA Y，WANG J Y，et al. First⁃line treatment of
AIO⁃94 randomized phase Ⅲ trial after a median follow⁃ anti⁃EGFR monoclonal antibody cetuximab β plus FOL⁃
up of 11 years［J］. J Clin Oncol，2012，30（16）：1926-1933 FIRI versus FOLFIRI alone in Chinese patients with RAS/
［16］KAPITEIJN E，MARIJNEN C A，NAGTEGAAL I D，et al. BRAF wild⁃type metastatic colorectal cancer：a random⁃
Preoperative radiotherapy combined with total mesorectal ized，phase 3 trial［J］. Signal Transduct Target Ther，
excision for resectable rectal cancer［J］. N Engl J Med， 2025，10（1）：147
2001，345（9）：638-646 ［26］TAIEB J，TABERNERO J，MINI E，et al. Oxaliplatin，flu⁃
［17］OKUDA H，SHIMOMURA M，IKEDA S，et al. A prospec⁃ orouracil，and leucovorin with or without cetuximab in pa⁃
tive feasibility study of uracil ⁃ tegafur and leucovorin as tients with resected stage Ⅲ colon cancer（PETACC⁃8）：
adjuvant chemotherapy for patients aged ≥ 80 years after an open⁃label，randomised phase 3 trial［J］. Lancet On⁃
curative resection of colorectal cancer，the HiSCO ⁃ 03 col，2014，15（8）：862-873
study［J］. Cancer Chemother Pharmacol，2023，91（4）： ［27］ALLEGRA C J，YOTHERS G，O’CONNELL M J，et al.