Page 131 - 《南京医科大学学报》自然科学版2026年第2期

第46卷第2期 甘晨云，王晓东. 运动对机体多组织器官影响的年龄异质性及其机制［J］.
2026年2月 南京医科大学学报（自然科学版），2026，46（2）：280-288 ·287 ·

BINI J，et al. Diet and exercise in frailty and sarcopenia. ［29］WANG T，ZHOU D，HONG Z. Sarcopenia and cachexia：
Molecular aspects［J］. Mol Aspects Med，2024，100：101322 molecular mechanisms and therapeutic interventions［J］.
［17］GORIANOVAS G，SKURVYDAS A，STRECKIS V，et al. MedComm（2020），2025，6（1）：e70030
Repeated bout effect was more expressed in young adult ［30］FURRER R，HANDSCHIN C. Molecular aspects of the
males than in elderly males and boys［J］. Biomed Res Int， exercise response and training adaptation in skeletal
2013，2013：218970 muscle［J］. Free Radic Biol Med，2024，223：53-68
［18］MESQUITA P H C，GODWIN J S，RUPLE B A，et al. Re⁃ ［31］SCHIFFERS C，LUNDBLAD L K A，HRISTOVA M，et al.
sistance training diminishes mitochondrial adaptations to Downregulation of DUOX1 function contributes to aging⁃
subsequent endurance training in healthy untrained related impairment of innate airway injury responses and
men［J］. Physiol，2023，601（17）：3825-3846 accelerated senile emphysema［J］. Am J Physiol Lung
［19］WANG R，ZHANG X，REN H，et al. Effects of different Cell Mol Physiol，2021，321（1）：L144-L158
exercise types on visceral fat in young individuals with ［32］PUGH J N，STRETTON C，MCDONAGH B，et al. Exer⁃
obesity aged 6-24 years old：a systematic review and meta cise stress leads to an acute loss of mitochondrial proteins
⁃analysis［J］. Front Physiol，2022，13：987804 and disruption of redox control in skeletal muscle of older
［20］VANDER WINDT D J，SUD V，ZHANG H，et al. The ef⁃ subjects ：an underlying decrease in resilience with
fects of physical exercise on fatty liver disease［J］. Gene aging［J］. Free Radic Biol Med，2021，177：88-99
Expr，2018，18（2）：89-101 ［33］LIU J，PENG W H，JIANG J J，et al. Research progress in
［21］BOENO F P，RAMIS T R，MUNHOZ S V，et al. Effect of the cardiovascular disease field involving irisin［J］. J Car⁃
aerobic and resistance exercise training on inflammation， diovasc Med Cardiol. 2025，12：65-71
endothelial function and ambulatory blood pressure in ［34］PAOLETTI I，COCCURELLO R. Irisin：a multifaceted hor⁃
middle⁃aged hypertensive patients［J］. Hypertens，2020， mone bridging exercise and disease pathophysiology［J］.
38（12）：2501-2509 Int J Mol Sci，2024，25（24）：13480
［22］MOREIRA J B N，WOHLWEND M，WISLØFF U. Exer⁃ ［35］HACHISU M，OBAYASHI M，KOGO M，et al. Psychoso⁃
cise and cardiac health：physiological and molecular in⁃ matic health in elderly people for preventing frailty：the
sights［J］. Nat Metab，2020，2（9）：829-839 role of IGF⁃1 and BDNF in the muscle and the brain［J］.
［23］REISMAN E G，BOTELLA J，HUANG C，et al. Fibre⁃spe⁃ Aging Sci，2020，8：223
cific mitochondrial protein abundance is linked to resting ［36］WANG Z，SUN T，YU J，et al. FGF21：a sharp weapon in
and post⁃training mitochondrial content in the muscle of the process of exercise to improve NAFLD［J］. Front Bios⁃
men［J］. Nat Commun，2024，15（1）：7677 ci（Landmark Ed），2023，28（12）：351
［24］BINET E R，MCKENNA C F，SALVADOR A F，et al. Sex⁃ ［37］SYED M，SKONBERG C，HANSEN S H. Inhibition of
based comparisons of muscle cellular adaptations after 10 ATP synthesis by fenbufen and its conjugated metabolites
weeks of progressive resistance training in middle ⁃ aged in rat liver mitochondria［J］.Toxicol In Vitro，2016，31：
adults［J］. Appl Physiol（1985），2023，134（1）：116-129 23-29
［25］REFALO M C，NUCKOLS G，GALPIN A J，et al. Sex dif⁃ ［38］TSAO C W，ADAY A W，ALMARZOOQ Z I，et al. Heart
ferences in absolute and relative changes in muscle size disease and stroke statistics ⁃ 2023 update：a report from
following resistance training in healthy adults：a systematic the American Heart Association［J］. Circulation，2023，
review with Bayesian meta⁃analysis［J］. PeerJ，2025，13： 147（8）：e93-e621
e19042 ［39］NO M H，HEO J W，YOO S Z，et al. Effects of aging and
［26］LIM C，NUNES E A，CURRIER B S，et al. An evidence⁃ exercise training on mitochondrial function and apoptosis
based narrative review of mechanisms of resistance exer⁃ in the rat heart［J］.Pflugers Arch，2020，472（2）：179-
cise ⁃ induced human skeletal muscle hypertrophy［J］. 193
Med Sci Sports Exerc，2022，54（9）：1546-1559 ［40］OHTA M，HIRAO N，MORI Y，et al. Effects of bench step
［27］BARONE M，BACCARO P，MOLFINO A. An overview of exercise on arterial stiffness in post⁃menopausal women：
sarcopenia：focusing on nutritional treatment approaches［J］. contribution of IGF⁃1 bioactivity and nitric oxide produc⁃
Nutrients，2025，17（7）：1237 tion［J］. Growth Horm IGF Res，2012，22（1）：36-41
［28］WALZIK D，WENCES CHIRINO T Y，ZIMMER P，et al. ［41］KIM H B，SEO M W，JUNG H C. Effects of aerobic vs. re⁃
Molecular insights of exercise therapy in disease preven⁃ sistance exercise on vascular function and vascular endo⁃
tion and treatment［J］. Signal Transduct Target Ther， thelial growth factor in older women［J］. Healthcare（Ba⁃
2024，9（1）：138 sel），2023，11（18）：2479