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neuroinflammation[J]. Front Immunol,2023,14:1197422 Picrasma quassioides(D. Don)Benn. ameliorates lipopoly⁃
[5] KARVE I P,TAYLOR J M,CRACK P J. The contribution saccharide(LPS)⁃induced astrocyte activation and asso⁃
of astrocytes and microglia to traumatic brain injury[J]. ciated brain endothelial disruption[J]. Phytomedicine,
Br J Pharmacol,2016,173(4):692-702 2022,101:154108
[6] KALRA S,MALIK R,SINGH G,et al. Pathogenesis and [17]LI J L,YANG K H,YAO F C,et al. Lentivirus⁃mediated
management of traumatic brain injury(TBI):role of neuro⁃ RNA interference targeting HMGB1 modulates AQP1 to
inflammation and anti⁃inflammatory drugs[J]. Inflammo⁃ reduce pain induced by chronic compression of the dorsal
pharmacology,2022,30(4):1153-1166 root ganglia[J]. Front Pharmacol,2024,15:1469223
[7] PURNELL B S,ALVES M,BOISON D. Astrocyte⁃neuron [18]MATTHEWS H K,BERTOLI C,DE BRUIN R A M. Cell
circuits in epilepsy[J]. Neurobiol Dis,2023,179:106058 cycle control in cancer[J]. Nat Rev Mol Cell Biol,2022,
[8] 王一凡,谢金玉,陈迎玉,等. STK25在星形胶质细胞活 23(1):74-88
化和EAE小鼠病变进程中的作用[J]. 南京医科大学学 [19]BALIC J J,ALBARGY H,LUU K,et al. STAT3 serine
报(自然科学版),2023,43(3):311-318 phosphorylation is required for TLR4 metabolic repro⁃
WANG Y F,XIE J Y,CHEN Y Y,et al. The role of gramming and IL⁃1β expression[J]. Nat Commun,2020,
STK25 in astrocyte activation and pathological changes in 11(1):3816
EAE mice[J]. Journal of Nanjing Medical University [20]陈贝宁,杨清湖,袁增强,等. 亨廷顿舞蹈症中星形胶质
(Natural Sciences),2023,43(3):311-318 细胞转录异质性分析[J]. 南京医科大学学报(自然科
[9] CAMERON E G,NAHMOU M,TOTH A B,et al. A molecu⁃ 学版),2025,45(4):487-497
lar switch for neuroprotective astrocyte reactivity[J]. CHEN B N,YANG Q H,YUAN Z Q,et al. The transcrip⁃
Nature,2024,626(7999):574-582 tional heterogeneity of astrocytes in Huntington’s di ⁃
[10]LIDDELOW S A,GUTTENPLAN K A,CLARKE L E,et sease[J]. Journal of Nanjing Medical University(Natural
al. Neurotoxic reactive astrocytes are induced by activated Sciences),2025,45(4):487-497
+
microglia[J]. Nature,2017,541(7638):481-487 [21]ZHANG Q,LIU C,SHI R B,et al. Blocking C3d /GFAP +
[11]SHIOMI K,UCHIDA H,KEINO⁃MASU K,et al. Ccd1,a A1 astrocyte conversion with semaglutide attenuates blood⁃
novel protein with a DIX domain,is a positive regulator in brain barrier disruption in mice after ischemic stroke[J].
the Wnt signaling during zebrafish neural patterning[J]. Aging Dis,2022,13(3):943-959
Curr Biol,2003,13(1):73-77 [22]LV J W,YU H,SHAN F L,et al. Effect of myelin debris
[12]KWAN V,MEKA D P,WHITE S H,et al. DIXDC1 phos⁃ on the phenotypic transformation of astrocytes after spinal
phorylation and control of dendritic morphology are im⁃ cord injury in rats[J]. Neuroscience,2024,547:1-16
paired by rare genetic variants[J]. Cell Rep,2016,17 [23]CUI D M ,ZENG T ,REN J ,et al. KLF4 knockdown
(7):1892-1904 attenuates TBI⁃induced neuronal damage through p53 and
[13]MARTIN P M,STANLEY R E,ROSS A P,et al. DIXDC1 JAK⁃STAT3 signaling[J]. CNS Neurosci Ther,2017,23
contributes to psychiatric susceptibility by regulating den⁃ (2):106-118
dritic spine and glutamatergic synapse density via GSK3 [24]DING W,CAI C,ZHU X M,et al. Parthenolide amelio⁃
and Wnt/β⁃catenin signaling[J]. Mol Psychiatry,2018,23 rates neurological deficits and neuroinflammation in mice
(2):467-475 with traumatic brain injury by suppressing STAT3/NF⁃κB
[14]LU H J,JIANG R,TAO X L,et al. Expression of Dixdc1 and inflammasome activation[J]. Int Immunopharmacol,
and its role in astrocyte proliferation after traumatic brain 2022,108:108913
injury[J]. Cell Mol Neurobiol,2017,37(6):1131- [25]LIANG P Y,ZHANG X Y,ZHANG Y H,et al. Neurotoxic
1139 A1 astrocytes promote neuronal ferroptosis via CXCL10/
[15]YU Y,SHEN T J,ZHONG X L,et al. NEK6 is an injury⁃ CXCR3 axis in epilepsy[J]. Free Radic Biol Med,2023,
responsive kinase cooperating with STAT3 in regulation 195:329-342
of reactive astrogliosis[J]. Glia,2022,70(2):273-286 (收稿:2025-04-28;修回:2025-07-02;录用:2025-07-12)
[16]YUE Q,XU Y S,LIN L G,et al. Canthin⁃6⁃one(CO)from (本文编辑:陈汐敏)

